Cyclopenthiazide
- CAS No.
- 742-20-1
- Chemical Name:
- Cyclopenthiazide
- Synonyms
- su8341;salimid;salimed;navidrix;NAVIDREX;Navidreks;NSC 107679;Salurilo-C;Ciba 8341-Su;Ultra-Minzil
- CBNumber:
- CB1295254
- Molecular Formula:
- C13H18ClN3O4S2
- Molecular Weight:
- 379.88
- MDL Number:
- MFCD00865825
- MOL File:
- 742-20-1.mol
- MSDS File:
- SDS
| Melting point | 230° |
|---|---|
| Boiling point | 605.6±65.0 °C(Predicted) |
| Density | 1.3650 (rough estimate) |
| refractive index | 1.6100 (estimate) |
| storage temp. | Refrigerator |
| solubility | Acetonitrile (Slightly), DMSO (Slightly), Methanol (Sparingly) |
| form | Solid |
| pka | 9.00±0.40(Predicted) |
| color | White to Off-White |
| Water Solubility | 50mg/L(room temperature) |
| CAS DataBase Reference | 742-20-1(CAS DataBase Reference) |
| FDA UNII | VX4S2N85F5 |
| ATC code | C03AA07 |
| EPA Substance Registry System | 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(cyclopentylmethyl)-3,4-dihydro-, 1,1-dioxide (742-20-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335-H373 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| Toxicity | LD50 in rats, mice (mg/kg): 141.8 ±24, 232.4 ±25 i.v. (Barrett) |
Cyclopenthiazide price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | C988420 | Cyclopenthiazide | 742-20-1 | 25mg | $185 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0005912 | CYCLOPENTHIAZIDE 95.00% | 742-20-1 | 10MG | $255.15 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC146926 | Cyclopenthiazide | 742-20-1 | 10mg | $160 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC146926 | Cyclopenthiazide | 742-20-1 | 25mg | $300 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC146926 | Cyclopenthiazide | 742-20-1 | 50mg | $550 | 2021-12-16 | Buy |
Cyclopenthiazide Chemical Properties,Uses,Production
Uses
Antihypertensive;Sodium Chloride Symporter Inhibitor
Uses
Cyclopenthiazide is a thiazide diuretic. Cyclopenthiazide is used in the treatment of oedema caused by conditions such as kidney disease, liver cirrhosis and pre-menstrual syndrome as well as in the treatment of hypertension.
Definition
ChEBI: 6-chloro-3-(cyclopentylmethyl)-1,1-dioxo-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-7-sulfonamide is a benzothiadiazine.
World Health Organization (WHO)
Cyclopenthiazide, a thiazide diuretic, was introduced in 1968. It continues to be used mainly in combination drugs.
Clinical Use
Thiazide diuretic:
Hypertension
Heart failure
Oedema
Drug interactions
Potentially hazardous interactions with other drugs
Analgesics: increased risk of nephrotoxicity with
NSAIDs; antagonism of diuretic effect. Anti-arrhythmics: hypokalaemia leads to increased
cardiac toxicity; effects of lidocaine and mexiletine
antagonised.
Antibacterials: avoid administration with
lymecycline.
Antidepressants: increased risk of hypokalaemia
with reboxetine; enhanced hypotensive effect with
MAOIs; increased risk of postural hypotension with
tricyclics.
Antiepileptics: increased risk of hyponatraemia with
carbamazepine.
Antifungals: increased risk of hypokalaemia with
amphotericin.
Antihypertensives: enhanced hypotensive effect;
increased risk of first dose hypotension with postsynaptic alpha-blockers like prazosin; hypokalaemia
increases risk of ventricular arrhythmias with sotalol.
Antipsychotics: hypokalaemia increases risk
of ventricular arrhythmias with amisulpride;
enhanced hypotensive effect with phenothiazines;
hypokalaemia increases risk of ventricular
arrhythmias with pimozide - avoid.
Atomoxetine: hypokalaemia increases risk of
ventricular arrhythmias.
Cardiac glycosides: increased toxicity if hypokalaemia
occurs.
Ciclosporin: increased risk of nephrotoxicity and
possibly hypomagnesaemia.
Cytotoxics: increased risk of ventricular arrhythmias
due to hypokalaemia with arsenic trioxide; increased
risk of nephrotoxicity and ototoxicity with platinum
compounds.
Lithium: excretion reduced, increased toxicity
Metabolism
Cyclopenthiazide appears to be entirely excreted unchanged in the urine.
Cyclopenthiazide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 994 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569265 +86-18612256290 | 1056@dideu.com | China | 3581 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
View Lastest Price from Cyclopenthiazide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-09-11 | Cyclopenthiazide
742-20-1
|
US $80.00 / kg | 1kg | 99% | 10000tons | Anhui Ruihan Technology Co., Ltd | |
 |
2021-08-12 | Cyclopenthiazide
742-20-1
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-07-20 | Cyclopenthiazide
742-20-1
|
US $1.00-1.00 / KG | 1g | 99% | 50tons | Shaanxi Dideu Medichem Co. Ltd |
-
- Cyclopenthiazide
742-20-1
- US $80.00 / kg
- 99%
- Anhui Ruihan Technology Co., Ltd
-
- Cyclopenthiazide
742-20-1
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Cyclopenthiazide
742-20-1
- US $1.00-1.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd