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Dmt-2'fluoro-da(bz) amidite

Dmt-2'fluoro-da(bz) amidite structure

CAS No.: 136834-22-5

Chemical Name:: Dmt-2'fluoro-da(bz) amidite

Synonyms: 2’-F-dA(Bz) Amidite;2'-F-Bz-A Phosphoramidite;Bz-2'-F-dA Phosphoramidite;Dmt-2'fluoro-da(bz) amidite;Dmt-2'fluoro-da(bz) amidite;2'-F-Bz-dA Phosphoramidite;2'-F-N6-Bz-dA phosphoramidite;2'-F-Bz-dA-CE-Phosphoramidite;2'-F-dA(Bz)-CE Phosphoramidite;N6-Bz-5'-O-DMT-2'-fluoro-dA-CE

CBNumber:: CB13141318

Molecular Formula:: C47H51FN7O7P

Molecular Weight:: 875.92

MDL Number:: MFCD12912392

MOL File:: 136834-22-5.mol

Last updated:2023-12-12 16:19:43

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Dmt-2'fluoro-da(bz) amidite Properties

storage temp.	Inert atmosphere,Store in freezer, under -20°C
form	Powder
pka	7.87±0.43(Predicted)
InChIKey	ZDIBABNMVQPXHU-JWQXGDSTNA-N

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Dmt-2'fluoro-da(bz) amidite price More Price(20)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Alfa Aesar	J64064	N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxyadenosine-3'-(2-cyanoethyl diisopropylphosphoramidite), 98%	136834-22-5	1g	$123.65	2024-03-01	Buy
TRC	B208313	(2R,3R,4R,5R)-5-(6-Benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl(2-cyanoethyl)Diisopropylphosphoramidite	136834-22-5	1g	$240	2021-12-16	Buy
AK Scientific	2404CT	Dmt-2'fluoro-da(bz)amidite	136834-22-5	500mg	$151	2021-12-16	Buy
AK Scientific	2404CT	Dmt-2'fluoro-da(bz)amidite	136834-22-5	1g	$218	2021-12-16	Buy
Biosynth Carbosynth	PB08393	N6-Benzoyl-2'-deoxy-5'-O-DMT-2'-fluoroadenosine 3'-CE phosphoramidite	136834-22-5	2g	$220	2021-12-16	Buy

Product number	Packaging	Price	Buy
J64064	1g	$123.65	Buy
B208313	1g	$240	Buy
2404CT	500mg	$151	Buy
2404CT	1g	$218	Buy
PB08393	2g	$220	Buy

Dmt-2'fluoro-da(bz) amidite Chemical Properties,Uses,Production

Chemical Properties

White to Light yellow powder to crystal.

Uses

(2R,3R,4R,5R)-5-(6-Benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite (Dmt-2'fluoro-da(bz) amidite) is an adenosine derivative used in the preparation of modified nucleotides to improve metabolic stability and ellicit gene silencing, and in the synthesis of microRNA inhibitors.

Synthesis

3-((Bis(diisopropylamine)phosphanyl)oxy)propanenitrile (6.42 g, 21.3 mmol, 6.77 mL, 1.8 eq) was added to a solution of N-(9-((2R,3R,4R,5R)-5-((bis(4- methoxyphenyl)(phenyl)methoxy)methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)-9H- purine-6-yl)benzamide (8.0 g, 11.8 mmol, 1.0 eq) in DCM (42 mL) at 0 °C followed by DCI (2.24 g, 18.9 mmol, 1.6 eq). The mixture was warmed to 25 °C and stirred for 3 hours. Two parallel reactions were carried out. The combined remedies were then diluted with DCM (150 mL), the organic layer was washed with sat NaHCO3 solution (200 mL) and brine (100 mL), dried over Na2SO4, filtered and concentrated, the crude was purified by column chromatography to give Dmt-2'fluoro-da(bz) amidite (18.0 g, 18.5 mmol, 78.1% yield, 90% purity) as a white solid.

Dmt-2'fluoro-da(bz) amidite Preparation Products And Raw materials

Raw materials

Preparation Products

Dmt-2'fluoro-da(bz) amidite Suppliers

Global( 128)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Wuhu Nuowei chemistry Co., Ltd.	+86-0553-2911116-802 +undefined17756524438	sales1@nuowei-chem.com	China	1642	58
Hefei Huana Biomedical Technology Co.,Ltd.	+86-15900695956	shiqin.he@huanaok.com.cn	China	96	58
Yunbio Tech Co.,Ltd.	+86-010-60605551 +86-18046518538	yunbiochem@126.com	China	321	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15956	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10247	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5738	58
NINGBOBENKANGJS PHARMTECHCO., LTD	+8615990591583 15990591583		CHINA	2029	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23556	58
Finetech Industry Limited	+86-27-87465837 +8618971612321	info@finetechnology-ind.com	China	9634	58

Supplier	Advantage
Wuhu Nuowei chemistry Co., Ltd.	58
Hefei Huana Biomedical Technology Co.,Ltd.	58
Yunbio Tech Co.,Ltd.	58
Shanghai Daken Advanced Materials Co.,Ltd	58
Shenzhen Nexconn Pharmatechs Ltd	58
BOC Sciences	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58
NINGBOBENKANGJS PHARMTECHCO., LTD	58
ANHUI WITOP BIOTECH CO., LTD	58
Finetech Industry Limited	58

View Lastest Price from Dmt-2'fluoro-da(bz) amidite manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-03-22	2'-F-dA(Bz) CE Phosphoramidite 136834-22-5	US $100.00 / kg	0.009999999776482582kg	99%	5tons	SHANGHAI NOVRIBO BIOTECH
2023-03-14	N6-Bz-5'-O-DMT-2'-fluoro-dA-CE 136834-22-5	US $0.00 / mg	100mg	≥99%	20tons	Hefei Huana Biomedical Technology Co.,Ltd.
2022-09-27	N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoroadenosine 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite] 136834-22-5	US $0.00-0.00 / kg	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.

2'-F-dA(Bz) CE Phosphoramidite
136834-22-5
US $100.00 / kg
99%
SHANGHAI NOVRIBO BIOTECH

N6-Bz-5'-O-DMT-2'-fluoro-dA-CE
136834-22-5
US $0.00 / mg
≥99%
Hefei Huana Biomedical Technology Co.,Ltd.

N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoroadenosine 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
136834-22-5
US $0.00-0.00 / kg
98%
Henan Aochuang Chemical Co.,Ltd.

N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoroadenosine 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite] (2R,3R,4R,5R)-5-(6-Benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite DMT-2'-F-dA(Bz)-CE Phosphoramidite 5'-Dimethoxytrityl-N-Benzoyl-2'-fluoro-3'-[(2-cyanoethyl)-(N,Ndiisopropyl)]-phosphoramidite-deoxyadenosine Bz-2'-F-dA Phosphoramidite (2R,3R,4R,5R)-5-(6-Benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite, >97% N6-Benzoyl-5'-O-(4,4'-Dimethoxy trityl)-2'-deoxy-2'-fluoroadenosine-3'-O-[(2-cyanoethyl)-(N,N-diiso-propyl)]phosphoramidite 5'-DMT-2'-F-Bz-dA Phosphoramidite Dmt-2'fluoro-da(bz) amidite 2'-F-dA(Bz)-CE Phosphoramidite N6-Bz-5'-O-(4, 4'-dimethoxytrityl)-2'-fluoro-2'-deoxyadenosine-3'-CE-Phosphoramidite Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite 2'-F-N6-Bz-dA phosphoramidite 2'-DEOXY-2'-FLUORO-N6Bz-ADENOSINE-3'-CE-PHOSPHORAMIDITE 2'-fluoro-N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine-3'-CE-Phosphoramidite 5'-O-DMT-2'-Fluoro-N6-Benzoyl-2'-deoxyadenosine 3'-CE phosphoramidite 5'-O-DMT-2'-F-Benzoyl-Deoxyadenosine-CE Phosphoramidite DMT-2'-F-dA(bz) Phosphoramidite N6-Bz-5'-O-DMT-2'-fluoro-dA-CE 5'-O-DMT-2'-F-N6- Benzoyl-2'-Deoxy Adenosine -3’-Cyanoethyl Phosphoramidite 2'-Fluoro-N-Bz Adenosine Amidite N6-Benzoyl-5’-O-(4, 4’-dimethoxytrityl)-2’-fluoro-2’-deoxyadenosine-3’-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite DMTr-2'-F-dA(Bz)-3'-CE-Phosphoramidite 2’-F-dA(Bz) Amidite 5'-ODMT-2'-Fluoro-N-Bz Adenosine-3'-OCEPA Dmt-2'fluoro-da(bz) amidite 2'-F-Bz-A Phosphoramidite DMT-2'-F-dA(Bz)-CE Phosphoramidite 2'-F-Bz-dA-CE-Phosphoramidite 2'-fluoro-N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine-3'-CE-Phosphoramidite 2'-F-dA(Bz)-CE-Phosphoramidite 2'-F-Bz-dA Phosphoramidite 136834-22-5 Amidite