LAPACHOL
- CAS No.
- 84-79-7
- Chemical Name:
- LAPACHOL
- Synonyms
- Tecomin;CI 75490;LAPACHOL;NSC 11905;nsc-11905;taiguwood;Taigu Wood;Greenharten;Greenhartin;Groenhartin
- CBNumber:
- CB1339480
- Molecular Formula:
- C15H14O3
- Molecular Weight:
- 242.27
- MDL Number:
- MFCD00001679
- MOL File:
- 84-79-7.mol
- MSDS File:
- SDS
| Melting point | 141-143 °C(lit.) |
|---|---|
| Boiling point | 325.09°C (rough estimate) |
| Density | 1.2077 (rough estimate) |
| refractive index | 1.5740 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | ethanol: soluble10mg/mL, clear, light yellow to yellow |
| pka | 4.81±0.10(Predicted) |
| Colour Index | 75490 |
| form | Solid |
| color | Yellow to Dark Yellow |
| Merck | 13,5382 |
| InChIKey | CIEYTVIYYGTCCI-UHFFFAOYSA-N |
| LogP | 2.516 (est) |
| CAS DataBase Reference | 84-79-7 |
| EWG's Food Scores | 1 |
| FDA UNII | B221938VB6 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 20/21/22-36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | QL8750000 | |||||||||
| Toxicity | LD50 in male, female BALB/c mice (g/kg): 0.487; 0.792 orally (Morrison) | |||||||||
| NFPA 704 |
|
LAPACHOL price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHL89521 | Lapachol phyproof? Reference Substance | 84-79-7 | 20mg | $288 | 2024-03-01 | Buy |
| Sigma-Aldrich | 142905 | Lapachol 98% | 84-79-7 | 250mg | $108 | 2024-03-01 | Buy |
| Cayman Chemical | 30190 | Lapachol | 84-79-7 | 250mg | $66 | 2024-03-01 | Buy |
| Cayman Chemical | 30190 | Lapachol | 84-79-7 | 500mg | $120 | 2024-03-01 | Buy |
| Cayman Chemical | 30190 | Lapachol | 84-79-7 | 100mg | $36 | 2024-03-01 | Buy |
LAPACHOL Chemical Properties,Uses,Production
Description
Lapachol, a benzoquinone, is a secondary allergen in teak (Tectona grandis).
Occurrence
Lapacol (CI Natural Yellow 16; CI 75490) (lapachic acid, taiguie acid, tecomin) is a yellow pigment occurring in the wood of trees of the genus Tecoma, native to the West Indies and tropical South America. The shavings of the wood, treated with lime water, give an extract that dyes cotton yellow.
Uses
antineoplastic, antifungal
Uses
It was used in the synthesis of the lapachol metal complexes.
Uses
Lapachol was used in the synthesis of the lapachol metal complexes.
Definition
ChEBI: Lapachol is a hydroxy-1,4-naphthoquinone that is 1,4-naphthoquinone substituted by hydroxy and 3-methylbut-2-en-1-yl groups at positions 2 and 3, respectively. It is a natural compound that exhibits antibacterial and anticancer properties, first isolated in 1882 from the bark of Tabebuia avellanedae. It has a role as a plant metabolite, an antineoplastic agent, an antibacterial agent and an anti-inflammatory agent. It is a hydroxy-1,4-naphthoquinone and an olefinic compound.
General Description
Lapachol is natural naphthoquinone compound derived from Bignoniaceae (Tabebuia sp.).
Biochem/physiol Actions
Lapachol has antimicrobial properties against many pathogens. It has anti-inflammatory, analgesic and antibiotic properties. It is inhibitor of epithelial tumors in Drosophila melanogaster heterozygote.
Contact allergens
Lapachol, a benzoquinone, is a secondary allergen in teak (Tectona grandis L., Verbenaceae family), a wood largely used for various indoor and outdoor applications (doors, windows, etc.) because of its strong durability. It has similar reactivity to deoxylapachol. Seealso Chap. 46
Purification Methods
Crystallise Lapachol from pet ether/EtOH, EtOH or Et2O. [Beilstein 8 H 326, 8 I 644, 8 II 365, 8 III 2720.]
LAPACHOL Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
| Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 | info@konochemical.com | China | 2995 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81148696 +8615536356810 | 1047@dideu.com | China | 3408 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9641 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10326 | 58 |
