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Ethynyl estradiol

Description History Indications Pharmacodynamics Mechanism of Action Medical Uses Contraindications Side Effects Precautions Interactions
Ethynyl estradiol
Ethynyl estradiol structure
Chemical Name:
Ethynyl estradiol
Molecular Formula:
Formula Weight:
MOL File:

Ethynyl estradiol Properties

Melting point:
182-183 °C(lit.)
Boiling point:
378°C (rough estimate)
1.0944 (rough estimate)
refractive index 
-30 ° (C=0.4, Pyridine)
Flash point:
storage temp. 
room temp
ethanol: 50 mg/mL, clear, slightly yellow
pKa 10.32 (Uncertain)
CAS DataBase Reference
57-63-6(CAS DataBase Reference)
Proposition 65 List
NCI Drug Dictionary
ATC code
NIST Chemistry Reference
Ethinyl estradiol(57-63-6)
EPA Substance Registry System
Ethinyl estradiol (57-63-6)
  • Risk and Safety Statements
Signal word  Danger
Hazard statements  H225-H301+H311+H331-H350-H370-H302
Precautionary statements  P201-P210-P260-P280-P301+P310-P311-P301+P312+P330-P308+P313-P202-P264-P270-P405-P501
Hazard Codes  T,F
Risk Statements  45-22-39/23/24/25-23/24/25-11
Safety Statements  53-36/37/39-45-36/37-16
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  3
RTECS  RC8925000
HS Code  29372390
Toxicity LD50 oral in rat: 960mg/kg

Ethynyl estradiol price More Price(41)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich E-076 17α-Ethynylestradiol solution 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant? 57-63-6 1 mL $103 2021-12-16 Buy
Sigma-Aldrich E-076 17α-Ethynylestradiol solution 1.0mg/mL in methanol, ampule of 1mL, certified reference material 57-63-6 076-1ml $99.6 2021-12-16 Buy
Sigma-Aldrich 1260001 Ethinyl estradiol United States Pharmacopeia (USP) Reference Standard 57-63-6 150mg $366 2021-12-16 Buy
Sigma-Aldrich E1900000 Ethinyl Estradiol European Pharmacopoeia (EP) Reference Standard 57-63-6 $190 2021-12-16 Buy
Sigma-Aldrich BP421 Ethinyl Estradiol British Pharmacopoeia (BP) Assay Standard 57-63-6 $220 2021-12-16 Buy

Ethynyl estradiol Chemical Properties,Uses,Production


Ethynyl estradiol (EE) is a synthetic form of estrogen that is majorly employed in numerous hormonal contraceptives in combination with progestins. Occasionally, it is also used as a constituent of menopausal hormone therapy with combination with progestins for treating menopausal symptoms. Previously, the drug was used solely for numerous indications such as treatment of prostate cancer and gynecological disorders.
Ethynyl estradiol is a semisynthetic alkylated estradiol with a 17-alpha-ethinyl substitution. It is normally administred orally and is marketed mostly as a combination oral contraceptive under various brand names such as Alesse, Tri-cyclen, Yasmin, and Triphasil. A black box warning is normally labelled on the packaging that states that the drug should not be used in smoking women who are over 35 years old as it can lead to increased risk of serious cardiovascular side effects.


Ethynyl estradiol was first developed in 1930 and officially introduced for medical used in 1943. In the 1960s, the drug was widely used in birth control pills. EE is currently found in most combined forms of birth control pills, which makes it one of the most used estrogens.


Ethynyl estradiol is used for treatment of moderate to severe vasomotor symptoms such as night sweats, hot flashes, and flushing that are associated with the menopause, prostatic carcinoma-palliative therapy of advanced disease, female hypogonadism, as emergency contraceptive, breast cancer, and as an oral contraceptive.


Ethynyl estradiol is a synthetic derivative of the natural estrogen estradiol. The drug is one of two widely used in oral contraceptive pills. Mestranol is the other drug that is normally converted to ethinyl estradiol before it becomes biologically active. EE is used together with norethindrone as an oral contraceptive agent.

Mechanism of Action

The estrogen in the drug diffuse into their target cells before interacting with a protein receptor. Notably, target cells include the female reproductive tract, the hypothalamus, the mammary gland, and the pituitary. Estrogens act by increasing the hepatic synthesis of thyroid binding globulin (TBG), sex hormone binding globulin (SHBG) as well as other serum proteins. It also acts by suppressing follicle-stimulating hormone (FSH) from anterior pituitary. All these activities are initiated by fist binding to the estrogen receptors. The hypothalamic-pituitary system is suppressed by the combination of an estrogen with a progestin, which decreases the secretion of gonadorotropin-releasing hormone (GnRH).

Medical Uses

Ethnynyl estradiol is majorly used to control pregnancy after sex as a contraception in combined oral contraceptives (COC), which are also referred to as birth control. EE is not only used in preventing pregnancy but is also employed in the treatment of absence of menstruation, acne, as well as symptoms during menstruation. It majorly works by preventing ovulation (the release of an egg) during the menstrual cycle. Further, it acts by making the vaginal fluid thicker to help in preventing sperm from fertilizing the released egg. It also changes the lining of the uterus to prevent attachment of a fertilized egg. EE also works by making the menstruation cycle more regular, decreasing blood loss and painful periods, and decreasing the risk of ovarian cysts.
EE is also used as menopausal hormone therapy (HRT) which has numerous benefits such as vaginal itching, vaginal dryness (which normally causes pain during sexual intercourse), and depressed mood. Previously, it was used as a constituent of feminizing hormone therapy for transgender women; however, the use of estradiol has largely superseded it in this therapy. The drug can also be used in preventing osteoporosis and in treating hypogonadism in women and has been used as palliative care for breast cancer in women and prostate cancer in men.


Ethnynyl estradiol should not be prescribed to individuals with history of susceptibility to venous or arterial thrombosis (blood clots) as it can lead to increased cardiovascular problems such as myocardial infarction, venous thromboembolism, and ischemic stroke. As such, it women with acute deep vein thrombosis or pulmonary embolism, any vascular disease history of DVT/PE, and complicated valvular heart disease are not advised to take the drug.

Side Effects

The side effects of EE include vomiting, nausea, headache, tenderness of the breast, abdominal cramps/bloating, swelling of the feet/ankles, and change in weight. In case of severe effects, one should immediately contact the doctor. EE can also cause irregular periods, which is considered normal.


Before taking EE, it is important to inform the doctor or pharmacist if you allergic to the drug or to any other estrogens such as mestranol. It is also important to inform the doctor if one has a medical history of blood clots, for instance in the eyes, legs, and lungs. The medication can also affect blood sugar levels if one is diabetic. However, it is important to monitor the blood sugar levels and share it with the doctor in case one is using the drug.


Drug interactions may change how EE works or might increase its side effects. Products that can interact with the drug include aromatase inhibitors (such as exemestane and anastrozole), tizanidine, tamoxifen, and tranexamic. It can also interact with certain combination products that are normally used to treat chronic hepatitis C. some drugs interact with EE by decreasing the amount of the drug in the body.


Estrogens direct the development of the female genotype in embryogenesis and at puberty. Estradiol is the major estrogen secreted by the premenopausal ovary. Ethynyl estradiol is a synthetic analog of 17β-estradiol (Item No. 10006315). A USP-approved grade of ethynyl estradiol is often formulated in combination with a progestin such as norgestrel (Item No. 10006319)/levonorgestrel (Item No. 10006318) or desogestrel and provided for use as an oral contraceptive. Efficacy of oral administration of ethynyl estradiol is facilitated by the ethynyl substitution at the C-17 position, which inhibits first pass hepatic metabolism. Ethynyl estradiol is also rapidly and almost completely absorbed from the gastrointestinal tract.

Chemical Properties

Off-White to Light-Yellow Crystalline Powder

Chemical Properties

Ethinylestradiol is a white to creamy-white powder. Odorless.

Chemical Properties

Estradiol, 17-β-is an odorless white to yellow crystalline substance.




A synthetic estradiol analog.


A metabolite of 17a-Ethynylestradiol


A synthetic steroid with high oral estrogenic potency


estrogen, plus progestogen as oral contraceptive


ChEBI: A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.

Manufacturing Process

In about 250 cc of liquid ammonia (cooled with dry ice and acetone) are dissolved about 7.5 g of potassium and into the solution acetylene is passed until the blue color has disappeared (about 3 hours). Then slowly a solution or suspension of 3 g of estrone in 150 cc of benzene and 50 cc of ether is added. The freezing mixture is removed, the whole allowed to stand for about 2 hours and the solution further stirred overnight. Thereupon the reaction solution is treated with ice and water, acidified with sulfuric acid to an acid reaction to Congo red and the solution extracted five times with ether. The combined ether extracts are washed twice with water, once with 5% sodium carbonate solution and again with water until the washing water is neutral. Then the ether is evaporated, the residue dissolved in a little methanol and diluted with water. The separated product is recrystallized from aqueous methanol. The yield amounts to 2.77 g. The 17-ethinyl-estradiol-3,17 thus obtained melts at 142°C to 144°C.

brand name

Estinyl (Schering); Feminone (Pharmacia & Upjohn); Lynoral (Organon).

Therapeutic Function


General Description

17 -Ethinyl estradiol has thegreatest advantage over other estradiol products of beingorally active. It is equal to estradiol in potency by injectionbut is 15 to 20 times more orally active. The primary metabolicpath for ethinyl estradiol is 2-hydroxylation bycytochrome P450 isozyme 3A4 (CYP3A4), followed byconversion to the 2- and 3-methyl ethers by catechol-Omethyltransferase.The 3-methyl ether of ethinyl estradiolis mestranol, USP, used in oral contraceptives. Mestranolis a prodrug that is 3-O-demethylated to the active ethinylestradiol. An oral dose of about 50 μg of mestranol has anestrogenic action approximately equivalent to 35 g oforal ethinyl estradiol. The demethylation is mainly mediatedby CYP2C9.

General Description

Fine white to creamy white powder. A synthetic steroid. Used in combination with progestogen as an oral contraceptive.

Air & Water Reactions

Air and light sensitive . Insoluble in water.

Reactivity Profile

Ethynyl estradiol may react vigorously with strong oxidizing agents. May react exothermically with reducing agents to generate gaseous hydrogen.

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition Ethynyl estradiol emits acrid smoke and fumes.

Fire Hazard

The flash point data for Ethynyl estradiol are not available. Ethynyl estradiol is probably combustible.

Biochem/physiol Actions

17α-Ethynylestradiol is an orally bio-active synthetic estrogen used as an oral contraceptive.

Safety Profile

Confirmed carcinogen with experimental carcinogenic, tumorigenic, and neoplastigenic data. Poison by intraperitoneal route. Moderately toxic by ingestion. Human systemic effects by ingestion: glandular effects. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes. See also ESTRADIOL

Chemical Synthesis

Ethinyl estradiol, 17α-ethinyl-1,3,5(10)-estratrien-3-17β-diol (28.1.26), is made either by condensing estrone with acetylene in the presence of potassium hydroxide (Favorskii reaction), or by reacting sodium acetylenide in liquid ammonia with estrone.

Potential Exposure

The working environment may be contaminated during sex hormone manufacture, especially during the extraction and purification of natural steroid hormones; grinding of raw materials; handling of powdered products and recrystallization. Airborne particles of sex hormones may be absorbed through the skin, ingested or inhaled. Enteric absorption results in quick inactivation of sex hormones in the liver. The rate of inactivation is decreased for the oral, alkylated steroid hormones (methyl testosterone, anabolic steroids, etc.). Sex hormones may accumulate and reach relatively high levels even if their absorption is intermittent. Consequently, repeated absorption of small amounts may be detrimental to health. Intoxication by sex hormones may occur in almost all the exposed workers if preventive measures are not taken. The effect in the industrial sector is more successful than the agricultural one (chemical caponizing of cockerels by stilbestrol implants and incorporation of estrogens in feed for body weight gain promotion in beef cattle), where measures taken are summary and the number of cases of intoxication is consequently bigger


UN3249 Medicine, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials

Purification Methods

17--Ethynylestradiol forms a hemihydrate on recrystallising from MeOH/H2O. It dehydrates on melting and remelts on further heating at m 182-184o. The UV has max at 281nm ( 2040) in EtOH. Its solubility is 17% in EtOH, 25% in Et2O, 20% in Me2CO, 25% in dioxane and 5% in CHCl3. [Petit & Muller Bull Soc Chim Fr 121 1951.] The diacetyl derivative has m 143-144o (from MeOH) and [] D 20 +1o (c 1, CHCl3) [Mills et al. J Am Chem Soc 80 6118 1958]. [Beilstein 6 IV 6877.]


May react exothermically with reducing agents to generate flammable gaseous hydrogen. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, and epoxides.

Waste Disposal

It is inappropriate and possibly dangerous to the environment to dispose of expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator

Ethynyl estradiol Preparation Products And Raw materials

Raw materials

Preparation Products

Ethynyl estradiol Suppliers

Global( 412)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Rixing Chemical CO.,LTD
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Beijing Cooperate Pharmaceutical Co.,Ltd
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Henan Tianfu Chemical Co.,Ltd.
0371-55170693 China 22607 55
Hangzhou FandaChem Co.,Ltd.
+86-571-56059825 CHINA 9128 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 CHINA 890 55
career henan chemical co
+86-0371-55982848 China 29954 58
Hubei Jusheng Technology Co.,Ltd.
027-59599243 CHINA 28229 58
Cangzhou Wanyou New Material Technology Co.,Ltd
18631714998 CHINA 914 58
hdzhl biotechnology co., ltd
86-13032617415 CHINA 1275 58
Xiamen AmoyChem Co., Ltd
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View Lastest Price from Ethynyl estradiol manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2022-01-18 Ethynyl estradiol
US $9.90-9.90 / g/Bag 10g/Bag 99.99%HPLC.USP42——Powder、Oil、Pills、Capsules、Tablets,Customized packaging 100KG/Month Wuhan Biocar Pharmacy Co., Ltd.
2022-01-18 Ethynyl estradiol
US $1.00 / g 10g 99.5% 1000kg Guangzhou Biocar Biotechnology Co.,Ltd.
2022-01-18 Ethynyl estradiol

Ethynyl estradiol Spectrum

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