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Uses Indications and Usage Adverse reactions Contradictions
β-ESTRADIOL structure
Chemical Name:
Molecular Formula:
Formula Weight:
MOL File:

β-ESTRADIOL Properties

Melting point:
178-179 °C(lit.)
D25 +76 to +83° (dioxane)
Boiling point:
355.44°C (rough estimate)
1.0708 (rough estimate)
refractive index 
80.4 ° (C=1, Dioxane)
Flash point:
storage temp. 
room temp
Practically insoluble in water, soluble in acetone, sparingly soluble in ethanol (96 per cent), slightly soluble in methylene chloride.
pKa 10.71±0.02(H2O(0.1% p-dioxane) t=25±0.1 I=0.03(KCl))(Approximate)
White to off-white
Water Solubility 
Soluble in dimethyl sulfoxide, ethanol , water, phosphate buffer saline, dimethyl formamide, acetone, dioxane and alkali hydroxides. Slightly soluble in vegetable oils.
Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference
50-28-2(CAS DataBase Reference)
EWG's Food Scores
NCI Dictionary of Cancer Terms
NCI Drug Dictionary
NIST Chemistry Reference
EPA Substance Registry System
Estradiol (50-28-2)
  • Risk and Safety Statements
Signal word  Danger
Hazard statements  H350-H360-H225-H302+H312+H332-H319-H351-H360Fd-H362
Precautionary statements  P210-P261-P302+P352+P312-P304+P340+P312-P337+P313-P403+P235-P202-P405-P501a-P201-P263-P281-P308+P313-P260-P280
Hazard Codes  T,Xn,F
Risk Statements  60-61-45-63-64-40-36-20/21/22-11-48
Safety Statements  53-22-36/37/39-45-36/37-26-16-36-20
RIDADR  2811
WGK Germany  3
RTECS  KG2975000
HazardClass  6.1
PackingGroup  III
HS Code  29372390
Toxicity LD50 subcutaneous in rat: > 300mg/kg

β-ESTRADIOL price More Price(30)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 3301 17β-Estradiol - CAS 50-28-2 - Calbiochem Most potent mammalian estrogenic hormone. 50-28-2 1 g $64.19 2021-03-22 Buy
Sigma-Aldrich 3301 17β-Estradiol Most potent mammalian estrogenic hormone. 50-28-2 1gm $66.9 2020-08-18 Buy
Sigma-Aldrich E1132 β-Estradiol analytical standard 50-28-2 1 vial $110 2021-03-22 Buy
Sigma-Aldrich E-060 17β-Estradiol solution 1.0?mg/mL in acetonitrile, ampule of 1?mL, certified reference material, Cerilliant? 50-28-2 1 mL $112 2021-03-22 Buy
Sigma-Aldrich 1250008 Estradiol United States Pharmacopeia (USP) Reference Standard 50-28-2 500mg $366 2021-03-22 Buy

β-ESTRADIOL Chemical Properties,Uses,Production


17β-Estradiol is the major estrogen secreted by the premenopausal ovary.This compound is a contaminant of emerging concern (CECs). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.

Indications and Usage

Estradiol is a white or milky white ordorless crystalline powder. It is soluble in dioxane and acetone, slightly soluble in ethanol, and insoluble in water.
Estradiol is the intermediate between estradiol valerate and estradiol benzoate, and it is a type of estrogen drug. It can be used to treat uterine functional bleeding, primary amenorrhea, menopausal syndrome, and prostate cancer. Estradiol can promote and adjust the normal growth of female sex organs and secondary sex characteristics, promote mammary duct maturation and growth, and aid in posseting. Estradiol can also be used in biochemical research.

Adverse reactions

In high dosages, estradiol can inhibit the release of anterior pituitary prolactin, thus decreasing breast milk secretion. However, nausea, vomiting and endometrial hyperplasia-induced bleeding may occur. Patients with liver or kidney failure should use with caution.


Do not use on breasts, vaginal area and vaginal mucosa.

Chemical Properties

White or almost white, crystalline powder or colourless crystals.

Chemical Properties

Estradiol, 17-β-is an odorless white to yellow crystalline substance.


17β-Estradiol is the major estrogen secreted by the premenopausal ovary.This compound is a contaminant of emerging concern (CECs). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.


Estradiol is the major estrogen secreted by the premenopausal ovary.


Estradiol USP (Estrace) is used to treat Breast cancer; prostatic carcinoma.


ChEBI: The 17beta-isomer of estradiol.

Acquired resistance

Estradiol is the most potent endogenous estrogen, exhibiting high affinity for the ER and high potency when administered parenterally. When administered orally, estradiol is promptly conjugated in the intestine and oxidatively metabolized by the liver, resulting in its low oral bioavailability and therapeutic effectiveness.

General Description

Estradiol, estra-1,3,5(10)-triene-3,17β-diol, is the most activeof the natural steroid estrogens. Although its 17β-OHgroup is vulnerable to bacterial and enzymatic oxidation toestrone, it can be temporarily protected as anester at C3 or C17, or permanently protected by adding a17α-alkyl group (e.g., 17α-ethinyl estradiol, the most commonlyused estrogen in oral contraceptives). The increasedoil solubility of the 17β-esters (relative to estradiol) permitsthe esters to remain in oil at the IM injection site for extendedperiods. These derivatives illustrate the principles of steroidmodification. Transdermal estradiolproducts avoid first-pass metabolism, allowing estradiol tobe as effective as oral estrogens for treating menopausalsymptoms. A new transdermal spray, Evamist, was approvedin 2007. Estradiol itself is typically not very effective orallybecause of rapid metabolism, but an oral formulation of micronizedestradiol that allows more rapid absorption of thedrug is available (Estrace). In addition to the oral and transdermalproducts, estradiol is also available in gel, cream, andvaginal ring formulations. The commercially available estradiolesters are the following:
Estradiol 3-acetate, USP (oral; vaginal ring)
Estradiol 17-valerate, USP (IM injection)
Estradiol 17-cypionate, USP (IM injection).


A carcinogen (OSHA).

Biological Activity

Endogenous estrogen receptor (ER) agonist (K i values are 0.12 and 0.13 nM for ER α and ER β respectively). Also high affinity ligand at membrane estrogen GPR30 receptors.

Contact allergens

Natural estradiol, used in transdermal systems for hormonal substitution, can induce allergic contact dermatitis, with the risk of systemic contact dermatitis after oral reintroduction.

Safety Profile

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. A promoter. Human reproductive effects by ingestion: ferthty effects. Experimental reproductive effects. Human mutation data reported. A steroid hormone much used in medicine. When heated to decomposition it emits acrid smoke and irritating fumes.

Chemical Synthesis

Estradiol, estra-1,3,5(10)-trien-3,17β-diol (28.1.17), is most easily made by reducing the keto-group of estrone by various reducing agents, in particular potassium borohydride.

Potential Exposure

The working environment may be contaminated during sex hormone manufacture, especially during the extraction and purification of natural steroid hormones; grinding of raw materials; handling of powdered products and recrystallization. Airborne particles of sex hormones may be absorbed through the skin, ingested or inhaled. Enteric absorption results in quick inactivation of sex hormones in the liver. The rate of inactivation is decreased for the oral, alkylated steroid hormones (methyl testosterone, anabolic steroids, etc.). Sex hormones may accumulate and reach relatively high levels even if their absorption is intermittent. Consequently, repeated absorption of small amounts may be detrimental to health. Intoxication by sex hormones may occur in almost all the exposed workers if preventive measures are not taken. The effect in the industrial sector is more successful than the agricultural one (chemical caponizing of cockerels by stilbestrol implants and incorporation of estrogens in feed for body weight gain promotion in beef cattle), where measures taken are summary and the number of cases of intoxication is consequently bigger


UN3249 Medicine, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials

Purification Methods

17-Estradiol (previously known as -estradiol) is purified by chromatography on SiO2 (toluene/EtOAc 4:1) and recrystallised from CHCl3/hexane or 80% EtOH. It is stable in air, is insoluble in H2O, and is precipitated by digitonin. The UV has max at 225 and 280 nm. The diacetate [3434-88-6] has m 97-98o and forms leaflets from aqueous EtOH. The 3-benzoate crystallises from aqueous MeOH withm 193o and [] D 25 +58o to 63o (c 1, dioxane). [Meischer & Scholz Helv Chim Acta 20 263, 1237 1937, Biochem J 32 1273 1938, Oppolzer & Roberts Helv Chim Acta 63 1703 1980, Inhoffen & Zühlsdorff Chem Ber 7 4 1914 1941, Beilstein 6 IV 6611.]

β-ESTRADIOL Preparation Products And Raw materials

Raw materials

Preparation Products

β-ESTRADIOL Suppliers

Global( 525)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Wuhan Nutra Biotechnology Co.,Ltd
8617786394783 CHINA 301 58
Hubei XinRunde Chemical Co., Ltd.
02783214688 CHINA 567 55
Hebei Bonster Technology Co.,Limited
0086-13315996897 CHINA 998 58
15377521700 +8615377521700
027-81302088 CHINA 869 58
Hebei Lvyang Biotechnology Co.,Ltd
15030198922 +86 15030198922
0311-68052281 CHINA 86 58
Hanhong Medicine Technology (Hubei) Co., Ltd.
+8618162639991 +86-027-86832068 CHINA 139 58
Baoji Guokang Healthchem co.,ltd
09178656283 CHINA 9483 58
Wuhan wingroup Pharmaceutical Co., Ltd
0086-27-87819568 CHINA 2478 58
Zhuozhou Wenxi import and Export Co., Ltd
+8613111626072 (WhatsApp)
Wechat: +8613111626072 Wickr me: waynehu CHINA 13187 58
Henan DaKen Chemical CO.,LTD.
+86-371-66670886 China 21032 58

View Lastest Price from β-ESTRADIOL manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-10-16 β-ESTRADIOL
US $277.00 / KG 10g 99% 1000kg/month Shanxi Lianxu New Material Co., LTD
2021-10-15 Estradiol
US $70.00 / KG 1KG 99% 10 tons Hanhong Medicine Technology (Hubei) Co., Ltd.
2021-10-15 Estradiol

β-ESTRADIOL Spectrum

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