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β-ESTRADIOL

Indications and Usage Adverse reactions Contradictions
β-ESTRADIOL
β-ESTRADIOL structure
CAS No.
50-28-2
Chemical Name:
β-ESTRADIOL
Synonyms
Evex;Altrad;Evorel;Macrol;Menest;Systen;Cimara;Bardiol;Climara;e(sub2)
CBNumber:
CB2200244
Molecular Formula:
C18H24O2
Formula Weight:
272.38
MOL File:
50-28-2.mol

β-ESTRADIOL Properties

Melting point:
178-179 °C(lit.)
alpha 
D25 +76 to +83° (dioxane)
Boiling point:
355.44°C (rough estimate)
Density 
1.0708 (rough estimate)
refractive index 
80.4 ° (C=1, Dioxane)
Flash point:
2℃
storage temp. 
2-8°C
solubility 
Practically insoluble in water, soluble in acetone, sparingly soluble in ethanol (96 per cent), slightly soluble in methylene chloride.
form 
powder
pka
pKa 10.71±0.02(H2O(0.1% p-dioxane) t=25±0.1 I=0.03(KCl))(Approximate)
color 
White to off-white
Water Solubility 
Soluble in dimethyl sulfoxide, ethanol , water, phosphate buffer saline, dimethyl formamide, acetone, dioxane and alkali hydroxides. Slightly soluble in vegetable oils.
Merck 
14,3703
BRN 
1914275
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
VOXZDWNPVJITMN-ZBRFXRBCSA-N
CAS DataBase Reference
50-28-2(CAS DataBase Reference)
NIST Chemistry Reference
Estra-1,3,5(10)-triene-3,17beta-diol(50-28-2)
EPA Substance Registry System
Estra-1,3,5(10)- triene-3,17-diol (17.beta.)-(50-28-2)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  T,Xn,F
Risk Statements  60-61-45-63-64-40-36-20/21/22-11-48
Safety Statements  53-22-36/37/39-45-36/37-26-16-36-20
RIDADR  2811
WGK Germany  3
RTECS  KG2975000
8-10
HazardClass  6.1
PackingGroup  III
HS Code  29372390
Hazardous Substances Data 50-28-2(Hazardous Substances Data)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H350 May cause cancer Carcinogenicity Category 1A, 1B Danger
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H360 May damage fertility or the unborn child Reproductive toxicity Category 1A, 1B Danger
H362 May cause harm to breast-fed children Reproductive toxicity, effects on or via lactation Additional category P201, P260, P263, P264, P270,P308+P313
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P263 Avoid contact during pregnancy/while nursing.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P281 Use personal protective equipment as required.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P405 Store locked up.
P403+P235 Store in a well-ventilated place. Keep cool.

β-ESTRADIOL price More Price(26)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 3301 17β-Estradiol Most potent mammalian estrogenic hormone. 50-28-2 1gm $64.4 2018-11-20 Buy
Sigma-Aldrich 1250008 Estradiol United States Pharmacopeia (USP) Reference Standard 50-28-2 500mg $352.8 2018-11-20 Buy
Alfa Aesar L03801 beta-Estradiol, 99% (dry wt.), ca 3% water 50-28-2 1g $35.6 2018-11-13 Buy
Alfa Aesar L03801 beta-Estradiol, 99% (dry wt.), ca 3% water 50-28-2 5g $126 2018-11-13 Buy
Cayman Chemical 10006315 17β-Estradiol ≥98% 50-28-2 500mg $15 2018-11-19 Buy

β-ESTRADIOL Chemical Properties,Uses,Production

Indications and Usage

Estradiol is a white or milky white ordorless crystalline powder. It is soluble in dioxane and acetone, slightly soluble in ethanol, and insoluble in water.
Estradiol is the intermediate between estradiol valerate and estradiol benzoate, and it is a type of estrogen drug. It can be used to treat uterine functional bleeding, primary amenorrhea, menopausal syndrome, and prostate cancer. Estradiol can promote and adjust the normal growth of female sex organs and secondary sex characteristics, promote mammary duct maturation and growth, and aid in posseting. Estradiol can also be used in biochemical research.

Adverse reactions

In high dosages, estradiol can inhibit the release of anterior pituitary prolactin, thus decreasing breast milk secretion. However, nausea, vomiting and endometrial hyperplasia-induced bleeding may occur. Patients with liver or kidney failure should use with caution.

Contradictions

Do not use on breasts, vaginal area and vaginal mucosa.

Chemical Properties

White or almost white, crystalline powder or colourless crystals.

Chemical Properties

Estradiol, 17-β-is an odorless white to yellow crystalline substance.

Uses

Potent mammalian estrogenic hormone produced by the ovary.

Uses

Estradiol is the major estrogen secreted by the premenopausal ovary.

Definition

ChEBI: The 17beta-isomer of estradiol.

General Description

Estradiol, estra-1,3,5(10)-triene-3,17β-diol, is the most activeof the natural steroid estrogens. Although its 17β-OHgroup is vulnerable to bacterial and enzymatic oxidation toestrone, it can be temporarily protected as anester at C3 or C17, or permanently protected by adding a17α-alkyl group (e.g., 17α-ethinyl estradiol, the most commonlyused estrogen in oral contraceptives). The increasedoil solubility of the 17β-esters (relative to estradiol) permitsthe esters to remain in oil at the IM injection site for extendedperiods. These derivatives illustrate the principles of steroidmodification. Transdermal estradiolproducts avoid first-pass metabolism, allowing estradiol tobe as effective as oral estrogens for treating menopausalsymptoms. A new transdermal spray, Evamist, was approvedin 2007. Estradiol itself is typically not very effective orallybecause of rapid metabolism, but an oral formulation of micronizedestradiol that allows more rapid absorption of thedrug is available (Estrace). In addition to the oral and transdermalproducts, estradiol is also available in gel, cream, andvaginal ring formulations. The commercially available estradiolesters are the following:
Estradiol 3-acetate, USP (oral; vaginal ring)
Estradiol 17-valerate, USP (IM injection)
Estradiol 17-cypionate, USP (IM injection).

Hazard

A carcinogen (OSHA).

Biological Activity

Endogenous estrogen receptor (ER) agonist (K i values are 0.12 and 0.13 nM for ER α and ER β respectively). Also high affinity ligand at membrane estrogen GPR30 receptors.

Contact allergens

Natural estradiol, used in transdermal systems for hormonal substitution, can induce allergic contact dermatitis, with the risk of systemic contact dermatitis after oral reintroduction.

Safety Profile

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. A promoter. Human reproductive effects by ingestion: ferthty effects. Experimental reproductive effects. Human mutation data reported. A steroid hormone much used in medicine. When heated to decomposition it emits acrid smoke and irritating fumes.

Potential Exposure

The working environment may be contaminated during sex hormone manufacture, especially during the extraction and purification of natural steroid hormones; grinding of raw materials; handling of powdered products and recrystallization. Airborne particles of sex hormones may be absorbed through the skin, ingested or inhaled. Enteric absorption results in quick inactivation of sex hormones in the liver. The rate of inactivation is decreased for the oral, alkylated steroid hormones (methyl testosterone, anabolic steroids, etc.). Sex hormones may accumulate and reach relatively high levels even if their absorption is intermittent. Consequently, repeated absorption of small amounts may be detrimental to health. Intoxication by sex hormones may occur in almost all the exposed workers if preventive measures are not taken. The effect in the industrial sector is more successful than the agricultural one (chemical caponizing of cockerels by stilbestrol implants and incorporation of estrogens in feed for body weight gain promotion in beef cattle), where measures taken are summary and the number of cases of intoxication is consequently bigger

First aid

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit

Shipping

UN3249 Medicine, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials

Purification Methods

17-Estradiol (previously known as -estradiol) is purified by chromatography on SiO2 (toluene/EtOAc 4:1) and recrystallised from CHCl3/hexane or 80% EtOH. It is stable in air, is insoluble in H2O, and is precipitated by digitonin. The UV has max at 225 and 280 nm. The diacetate [3434-88-6] has m 97-98o and forms leaflets from aqueous EtOH. The 3-benzoate crystallises from aqueous MeOH withm 193o and [] D 25 +58o to 63o (c 1, dioxane). [Meischer & Scholz Helv Chim Acta 20 263, 1237 1937, Biochem J 32 1273 1938, Oppolzer & Roberts Helv Chim Acta 63 1703 1980, Inhoffen & Zühlsdorff Chem Ber 7 4 1914 1941, Beilstein 6 IV 6611.]

β-ESTRADIOL Preparation Products And Raw materials

Raw materials

Preparation Products


β-ESTRADIOL Suppliers

Global( 335)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
02783214688 bruce@xrdchem.cn CHINA 552 55
Meihua Biological Technology Co.,Ltd
15175972705
031145896235 sales@hbmeihua.cn CHINA 215 58
Hebei Guanlang Biotechnology Co., Ltd.
+86-0311-66562153 whatsapp +8615203118427
+86-0311-66562153 sales@crovellbio.com CHINA 416 50
Changzhou Rongchuang Biotechnology Co., ltd.
0519-83991290 18115001290
0519-83991290 selena@rongchuangnet.com CHINA 39 55
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3217 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22043 58
Hebei Jiangkai Trading Co., Ltd
0086-17197824289/17197824028
alice@hbjkai.com CHINA 277 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20786 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32651 55
Rixing Chemical CO.,LTD
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View Lastest Price from β-ESTRADIOL manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-20 β-ESTRADIOL
50-28-2
US $1.00 / KG 1G 98% 100KG career henan chemical co
2018-03-07 Estradiol
50-28-2
US $2000.00 / KG 10UG >99% 10MT Hubei XinRunde Chemical Co., Ltd.
2018-09-30 B-Estradiol
50-28-2
US $50.00 / KG 1KG 99% 20 MT Hebei Huanhao Biotechnology Co., Ltd.

β-ESTRADIOL Spectrum


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