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ChemicalBook >> CAS DataBase List >>3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE

3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE

3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE Structure
3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE structure
CAS No.
622387-85-3
Chemical Name:
3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE
Synonyms
OXSI 2;Syk Inhibitor;3-[(1-METHYLINDOL-3-YL)METHYLIDENE]-2-OXO-1H-INDOLE-5-SULFONAMIDE;3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE;2,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2-oxo-1H-indole-5-sulfonamide;1H-Indole-5-sulfonamide, 2,3-dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2-oxo-;Inhibitor,Tyrosine,OXSI-2,Potassium,Inflammasome,PAR,Pyroptosis,Src,kinase,Piceatannol,Syk,OXSI2,Spleen tyrosine kinase,inhibit,signaling,GPVI,Inflammation
CBNumber:
CB1364747
Molecular Formula:
C18H15N3O3S
Molecular Weight:
353.39
MDL Number:
MFCD07776820
MOL File:
622387-85-3.mol
MSDS File:
SDS
Last updated:2023-05-21 10:59:17
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3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE Properties

storage temp. Store at -20°C
solubility Soluble in DMSO
form Orange powder solid.
Sensitive Light Sensitive
FDA UNII 5YZ3QBQ97C

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a

3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 574711 Syk Inhibitor - CAS 622387-85-3 - Calbiochem 622387-85-3 5mg $187 2024-03-01 Buy
Alfa Aesar J64281 Syk Inhibitor 622387-85-3 5mg $190 2023-06-20 Buy
Alfa Aesar J64281 Syk Inhibitor 622387-85-3 1mg $50.3 2021-12-16 Buy
Cayman Chemical 14829 Syk Inhibitor ≥95% (mixture of isomers) 622387-85-3 500μg $32 2024-03-01 Buy
Cayman Chemical 14829 Syk Inhibitor ≥95% (mixture of isomers) 622387-85-3 1mg $55 2024-03-01 Buy
Product number Packaging Price Buy
574711 5mg $187 Buy
J64281 5mg $190 Buy
J64281 1mg $50.3 Buy
14829 500μg $32 Buy
14829 1mg $55 Buy

3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE Chemical Properties,Uses,Production

Description

Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that upon phosphorylation binds to immunoreceptor tyrosine-based activation motifs (ITAMs) of FcRγ chains and mediates downstream signaling related to platelet function and inflammation. Syk inhibitor is an oxindole compound that potently blocks Syk activity with an IC50 value of 14 nM and inhibits FcεRI-mediated rat RBL-2H3 basophil cell degranulation (EC50 = 313 nM). At 2 μM, this compound completely abolishes convulxin-induced platelet aggregation and shape change.

Uses

OXSI 2 is a Syk selective inhibitor.

3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE Suppliers

Global( 38)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Career Henan Chemica Co 		+86-0371-86658258 15093356674; laboratory@coreychem.com China 30255 58
VDM Biochemicals 0330-2528181 sales@vdmbio.com United States 510 64
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9709 58
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Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6870 58
BOC Sciences -- info@bocsci.com USA 0 65
Amel Pharmatech Corporation 888-4366503 sales@amelpharmatech.com China 5351 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8141 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Career Henan Chemica Co 		58
VDM Biochemicals 64
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai Rechem science Co., Ltd. 58
Shanghai Hongye Biotechnology Co. Ltd 58
BOC Sciences 65
Amel Pharmatech Corporation 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
MedBioPharmaceutical Technology Inc 58

622387-85-3(3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE)Related Search:

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(Z)-3-((5-BROMO-1-(2-PHENOXYETHYL)-1H-INDOL-3-YL)METHYLENE)-1-ETHYL-5-(MORPHOLINOSULFONYL)INDOLIN-2-ONE (Z)-1-METHYL-5-(MORPHOLINOSULFONYL)-3-((1-(2-OXO-2-(PIPERIDIN-1-YL)ETHYL)-1H-INDOL-3-YL)METHYLENE)INDOLIN-2-ONE (Z)-N-(2-METHOXYETHYL)-2-(3-((1-METHYL-5-(MORPHOLINOSULFONYL)-2-OXOINDOLIN-3-YLIDENE)METHYL)-1H-INDOL-1-YL)ACETAMIDE

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Syk Inhibitor 3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE OXSI 2 2,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2-oxo-1H-indole-5-sulfonamide 3-[(1-METHYLINDOL-3-YL)METHYLIDENE]-2-OXO-1H-INDOLE-5-SULFONAMIDE 1H-Indole-5-sulfonamide, 2,3-dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2-oxo- Inhibitor,Tyrosine,OXSI-2,Potassium,Inflammasome,PAR,Pyroptosis,Src,kinase,Piceatannol,Syk,OXSI2,Spleen tyrosine kinase,inhibit,signaling,GPVI,Inflammation 622387-85-3 C18H15N3O3S pharmacetical Spleen Tyrosine Kinase Inhibitor