OLTIPRAZ
- CAS No.
- 64224-21-1
- Chemical Name:
- OLTIPRAZ
- Synonyms
- CD1400;OLTIPRAZ;RP-35972;NSC 347901;CCRIS 4048;BRN 0978110;OLTIPRAZ USP/EP/BP;Oltipraz (RP 35972;64224-21-1 OLTIPRAZ;Oltipraz (NSC-347901)
- CBNumber:
- CB1431766
- Molecular Formula:
- C8H6N2S3
- Molecular Weight:
- 226.34
- MDL Number:
- MFCD00868499
- MOL File:
- 64224-21-1.mol
- MSDS File:
- SDS
| Melting point | 165-166 |
|---|---|
| Boiling point | 408.1±55.0 °C(Predicted) |
| Density | 1.51±0.1 g/cm3(Predicted) |
| RTECS | JP1293000 |
| storage temp. | 2-8°C |
| solubility | DMSO: >20mg/mL |
| pka | 0.18±0.10(Predicted) |
| form | Solid |
| color | red |
| Sensitive | Light Sensitive |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
| InChIKey | CKNAQFVBEHDJQV-UHFFFAOYSA-N |
| NCI Dictionary of Cancer Terms | oltipraz |
| FDA UNII | 6N510JUL1Y |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37/39-36/37 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
OLTIPRAZ price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | O9389 | Oltipraz ≥98% (HPLC), powder | 64224-21-1 | 5mg | $108 | 2024-03-01 | Buy |
| Sigma-Aldrich | O9389 | Oltipraz ≥98% (HPLC), powder | 64224-21-1 | 25mg | $434 | 2024-03-01 | Buy |
| Alfa Aesar | H35120 | 4-Methyl-5-(2-pyrazinyl)-1,2-dithiole-3-thione | 64224-21-1 | 100mg | $149.65 | 2024-03-01 | Buy |
| Alfa Aesar | H35120 | 4-Methyl-5-(2-pyrazinyl)-1,2-dithiole-3-thione | 64224-21-1 | 500mg | $456.65 | 2024-03-01 | Buy |
| Cayman Chemical | 15118 | Oltipraz ≥98% | 64224-21-1 | 100mg | $97 | 2024-03-01 | Buy |
OLTIPRAZ Chemical Properties,Uses,Production
Description
Oltipraz (64224-21-1) upregulates the transcription factor NRF2 and prevents insulin resistance and obesity induced by high fat diet in C57BL/6J mice.1 Attenuates the progression of fibrosis in a rat model of nonalcoholic steatohepatitis.2 Oltipaz attenuates chronic hypoxia-induced cardiopulmonary alterations in mice.3 Promotes liver regeneration after partial hepatectomy.4 Off target effects: Activates constitutive androstane receptor (CAR).5
Chemical Properties
Dark Red Solid
Uses
schistosomicide, antineoplastic
Uses
Oltipraz is a synthetic, substituted 1,2-dithiole-3-thione previously used in humans as an antischistosomal agent. Animal studies have demonstrated that oltipraz is a potent inducer of Phase II detoxification enzymes, most notably glutathione-S-transferase (GST). Oltipraz is now known to be used for tumor prevention purposes.
Definition
ChEBI: A 1,2-dithiole that is 3H-1,2-dithiole-3-thione substituted at positions 4 and 5 by methyl and pyrazin-2-yl groups respectively.
General Description
Oltipraz, a dithiol derivative, is a member of dithiolethiones class of organosulfur compounds. It has anti-tumor, antioxidative, anti- inflammatory and radioprotective properties. It provides protection from numerous carcinogens. Oltipraz functions as a schistosomicide.
Biochem/physiol Actions
Oltipraz is an activator of Nrf2. Nrf2 (NF-E2-related factor 2) is a transcription factor that binds to antioxidant response elements (AREs) and activates these genes. Oltipraz activates Nrf2 and subsequently elevates expression of the detoxification genes encoding anti-oxidant and multidrug resistance-associated proteins to mediate its chemopreventive efficacy.
storage
Store at +4°C
References
1) Yu?et al. (2011),?Oltipraz upregulates the nuclear factor (erythroid-derived 2)-like 2 (NRF2) antioxidant system and prevents insulin resistance and obesity induced by a high-fat diet in C57BL/6J mice; Diabetologia,?54?922 2) Shimozono?et al. (2013),?Nrf2 activators attenuate the progression of nonalcoholic steatohepatitis-related fibrosis in a dietary rat model; Mol. Pharmacol,?84?62 3) Eba?et al. (2013),?The nuclear factor erythroid 2-related factor 2 activator oltipraz attenuates chronic hypoxia-induced cardiopulmonary alterations in mice; Am. J. Respir. Cell. Mol. Biol.,?49?324 4) Cho?et al. (2009), Oltipraz promotion of liver regeneration after partial hepatectomy: the role of PI3-kinase dependent C/EBPbeta and cyclin E regulation; Arch. Pharm. Res.,?32?625 5) Merrell?et al. (2008),?The Nrf2 activator oltipraz also activates the constitutive androstane receptor; Drug Metab. Dispos.,?36?1716
OLTIPRAZ Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21637 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29885 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32072 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 23025 | 58 |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9640 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
View Lastest Price from OLTIPRAZ manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-08 | Oltipraz
64224-21-1
|
US $31.00-71.00 / mg | 99.56% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-11-08 | Oltipraz
64224-21-1
|
US $31.00-71.00 / mg | 99.56% | 10g | TargetMol Chemicals Inc. | ||
 |
2022-01-15 | oltipraz
64224-21-1
|
US $0.00 / KG | 1KG | 98.2% | 100 tons | Honest Joy Holdings Limited
|