Germacrone
- CAS No.
- 6902-91-6
- Chemical Name:
- Germacrone
- Synonyms
- Germacron;3,7-Cyclodecadien-1-one, 3,7-dimethyl-10-(1-methylethylidene)-, (E,E)-;3,7-Cyclodecadien-1-one, 3,7-dimethyl-10-(1-methylethylidene)-, (3E,7E)-;GERMACRONE;GERMACRONE(RG);GerMacrol (obsol;(E,E)-GerMacrone;(E,E)-Germacra-3,7(11),9-trien-6-one;Germacra-3,7(11),9-trien-6-one, (E,E)-;Germacrone, 98%, from Curcuma zedoaria (Christm.) Rosc
- CBNumber:
- CB1497650
- Molecular Formula:
- C15H22O
- Molecular Weight:
- 218.33
- MDL Number:
- MFCD00210050
- MOL File:
- 6902-91-6.mol
- MSDS File:
- SDS
| Melting point | 55-58 °C |
|---|---|
| Boiling point | 153-157 °C(Press: 13 Torr) |
| Density | 0.9908 g/cm3 |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
| form | Solid |
| color | White to Off-White |
| λmax | 309nm(MeOH)(lit.) |
| BRN | 2047453 |
| Stability | Light Sensitive |
| LogP | 4.760 (est) |
| CAS DataBase Reference | 6902-91-6 |
| FDA UNII | E2WQ6N4FBP |
| NIST Chemistry Reference | 3,7-Cyclodecadien-1-one, 3,7-dimethyl-10-(1-methylethylidene)-, (e,e)-(6902-91-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P280-P305+P351+P338-P337+P313 | |||||||||
| Safety Statements | 23-24/25 | |||||||||
| RTECS | GU2210000 | |||||||||
| HS Code | 29142990 | |||||||||
| NFPA 704 |
|
Germacrone price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHL89677 | Germacrone phyproof? Reference Substance | 6902-91-6 | 10MG | $522 | 2024-03-01 | Buy |
| Sigma-Aldrich | 42924 | Germacrone ≥95.0% (HPLC) | 6902-91-6 | 10mg | $897 | 2022-05-15 | Buy |
| TCI Chemical | G0519 | Germacrone >98.0%(GC) | 6902-91-6 | 20mg | $178 | 2024-03-01 | Buy |
| TCI Chemical | G0519 | Germacrone >98.0%(GC) | 6902-91-6 | 100mg | $532 | 2024-03-01 | Buy |
| Cayman Chemical | 30111 | Germacrone | 6902-91-6 | 5mg | $68 | 2024-03-01 | Buy |
Germacrone Chemical Properties,Uses,Production
Description
Germacrone is a sesquiterpene that has been found in gingeraceae plants and has diverse biological activities. It inhibits pseudorabies virus (PRV) replication in Vero cells when used at concentrations ranging from 10 to 150 μM. Germacrone (50-250 μM) enhances cytotoxicity and apoptosis induced by doxorubicin in doxorubicin-resistant MCF-7/adr cells. In vivo, germacrone (5, 10, and 20 mg/kg) reduces body weight gain, visceral fat pad weight, serum insulin and plasma glucose levels, and hepatic lipid levels in a mouse model of high-fat diet-induced obesity. It decreases brain malondialdehyde (MDA) levels and activity of superoxide dismutase (SOD) and glutathione peroxidase (GPX), as well as reduces infarct volume in a rat model of ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO).
Uses
Germacrone is an antiviral isolate of Geranium macrorrhizum which inhibits and prevents early stage influenza virus infection. It also inhibits the proliferation of glioma cells by promoting apoptosis.
Definition
ChEBI: (E,E)-germacrone is a germacrane sesquiterpenoid that has formula C15H22O. It is a natural product found in traditional medicinal plants of the family Zingiberaceae. The compound exhibits a range of pharmacological activities including anti-inflammatory, anticancer, antiviral, anti-androgenic, antioxidant, antimicrobial, antifungal, neuroprotective and insecticidal activities. It has a role as a volatile oil component, an antiviral agent, an insecticide, an anti-inflammatory agent, an antioxidant, an antineoplastic agent, an apoptosis inducer, an autophagy inducer, an antimicrobial agent, an androgen antagonist, a neuroprotective agent, a plant metabolite, an antifungal agent, an antitussive, an antifeedant and a hepatoprotective agent. It is a germacrane sesquiterpenoid and an olefinic compound.
Synthesis Reference(s)
Tetrahedron Letters, 24, p. 3489, 1983 DOI: 10.1016/S0040-4039(00)86020-7
Hazard
A poison by ingestion
Safety Profile
A poison by ingestion. When heated to decomposition it emits acrid smoke and irritating vapors.
Germacrone Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 | info@konochemical.com | China | 2995 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-519-519-85557386 | marketing1@neostarunited.com | China | 8349 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
View Lastest Price from Germacrone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-02-24 | Germacrone
6902-91-6
|
US $0.00 / mg | 5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. | |
 |
2019-07-06 | (3Z,7Z)-3,7-Dimethyl-10-propan-2-ylidene-cyclodeca-3,7-dien-1-one
6902-91-6
|
US $1.00 / kg | 1g | 99% | 100KG | Career Henan Chemical Co |
-
- Germacrone
6902-91-6
- US $0.00 / mg
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
-
- (3Z,7Z)-3,7-Dimethyl-10-propan-2-ylidene-cyclodeca-3,7-dien-1-one
6902-91-6
- US $1.00 / kg
- 99%
- Career Henan Chemical Co