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Isoquinoline

Chemical Properties Usage Usage limitation Preparation Content analysis Category Toxicity grade Toxicity Acute toxicity Stimulus data Flammability hazard characteristics Storage Fire extinguishing agent
Isoquinoline
Isoquinoline
CAS No.
119-65-3
Chemical Name:
Isoquinoline
Synonyms
FEMA 2978;LEUCOLINE;ISOQINOLINE;ISOCHINOLIN;2-BENZAZINE;2-Benzanine;ISOQUINOLIN;Isochinoline;ISOQUINOLINE;Benzopyridine
CBNumber:
CB1690422
Molecular Formula:
C9H7N
Formula Weight:
129.16
MOL File:
119-65-3.mol

Isoquinoline Properties

Melting point:
26-28 °C(lit.)
Boiling point:
242-243 °C(lit.)
Density 
1.099 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.623(lit.)
FEMA 
2978 | ISOQUINOLINE
Flash point:
225 °F
storage temp. 
2-8°C
solubility 
5g/l
pka
5.42(at 20℃)
form 
Low Melting Solid
color 
Light brown
PH
7.5 (5g/l, H2O, 20℃)
Water Solubility 
practically insoluble
Merck 
14,5222
BRN 
107549
InChIKey
AWJUIBRHMBBTKR-UHFFFAOYSA-N
CAS DataBase Reference
119-65-3(CAS DataBase Reference)
NIST Chemistry Reference
Isoquinoline(119-65-3)
EPA Substance Registry System
Isoquinoline(119-65-3)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  T
Risk Statements  22-24-38-52/53-36/38-21/22-45
Safety Statements  36/37-45-36/37/39-61-53
RIDADR  UN 2811 6.1/PG 3
WGK Germany  2
RTECS  NW6825000
TSCA  Yes
HazardClass  6.1
PackingGroup  II
HS Code  29334900
Toxicity LD50 orally in rats: 360 mg/kg (Smyth)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H311 Toxic in contact with skin Acute toxicity,dermal Category 3 Danger P280, P302+P352, P312, P322, P361,P363, P405, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H350 May cause cancer Carcinogenicity Category 1A, 1B Danger
H412 Harmful to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 3 P273, P501
Precautionary statements:
P201 Obtain special instructions before use.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P321 Specific treatment (see … on this label).
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.
P501 Dispose of contents/container to..…

Isoquinoline price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 282162 Isoquinoline technical grade, 90-92% 119-65-3 100ml $47.3 2018-11-13 Buy
Sigma-Aldrich 68853 Isoquinoline analytical standard 119-65-3 1ml $59.2 2018-11-13 Buy
TCI Chemical I0182 Isoquinoline >95.0%(GC) 119-65-3 25g $21 2018-11-22 Buy
TCI Chemical I0182 Isoquinoline >95.0%(GC) 119-65-3 500g $124 2018-11-22 Buy
Alfa Aesar B21279 Isoquinoline, 97% 119-65-3 500g $186 2018-11-13 Buy

Isoquinoline Chemical Properties,Uses,Production

Chemical Properties

Colorless flaky crystal or liquid, similar fragrance to bitter almonds and Chervil, sweet taste, melting point 23℃,boiling point 243℃, soluble in ethanol and non-volatile oil, diluted inorganic acid and most organic solvents, slightly soluble in water.

Usage

Usage limitation

FEMA(mg/kg): Soft drinks 0.25,, cold drinks 0.25, sweets1.0; bakery products 0.004-1.0, moderate use (FDA§172.515,2000).

Preparation

Crude quinoline containing 83% quinoline, 15% isoquinoline and 2% methyl quinoline can be used as the raw material for the production of isoquinoline. However, the Distillation section from 237.5-239.5℃ and 243-246℃ is generally collected and used as the raw material for the extraction of isoquinoline. 13-28% of 2-methyl quinoline and 3.9% quinoline can be separated from this distillation section in the form of hydrochloride salt.
The isoquinoline fraction reacted with 98% sulfuric acid at 35℃ in alcohol solution to produce isoquinoline sulfonate. Isoquinoline sulfonate crystallizes faster than its homologues in the cooling process. After filtration, recrystallization was carried out with 85% ethanol, and then decomposed with 20% ammonia water. The generated oil layer was firstly washed with water, and then rectified to collect the fraction at242-243℃to obtain Isoquinoline with purity greater than 95%  It is separated by repeated freezing the coal tar with the boiling rangeat 238~250℃.

Content analysis

Determined by Gas chromatography and liquid chromatography and the chromatographic test conditions are the same as α-allyl ionone (03411).

Category

flammable liquid

Toxicity grade

middle toxic

Toxicity

GRAS(FEMA)

Acute toxicity

Oral – rat LD50: 360mg/kg

Stimulus data

Skin-rabbit  10 mg/24h mild;  eye-rabbit 250 μg severe.

Flammability hazard characteristics

Flammable in case of fire, high temperature and oxidants, Combustion produces toxic nitrogen oxide smog.

Storage

Completely packed, handle with care; Ventilated warehouse, away from open flame, high temperature, separated from strong acids.

Fire extinguishing agent

foam, carbon dioxide, dry powder, dry sand, water spray.

Chemical Properties

LIGHT BROWN LOW MELTLING SOLID

Uses

Manufacture of pharmaceuticals (such as nicotinic acid), dyes, insecticides, rubber accelerators, and in organic synthesis.

Definition

ChEBI: An ortho-fused heteroarene that is a benzopyridine in which the N atom not directly attached to the benzene ring.

Hazard

Toxic by ingestion.

Purification Methods

Dry isoquinoline with Linde type 5A molecular sieves or Na2SO4 and fractionally distil at reduced pressure. Alternatively, it can be refluxed with, and distilled from, BaO. It is also purified by fractional crystallisation from the melt and distilled from zinc dust. It forms a phosphate (m 135o) and a picrate (m 223o), which are purified by crystallisation, and the free base can be recovered and distilled. [Packer et al. J Am Chem Soc 80 905 1958.] The procedure for purification via the picrate comprises the addition of quinoline to picric acid dissolved in the minimum volume of 95% EtOH to yield yellow crystals which are washed with EtOH and air dried before recrystallising from acetonitrile. The crystals are dissolved in dimethyl sulfoxide (previously dried over 4A molecular sieves) and passed through a basic alumina column, on which picric acid is adsorbed. The free base in the effluent is extracted with n-pentane and distilled under vacuum. Traces of solvent from small quantities are removed by vapour phase chromatography. The hydrochloride crystallises from EtOH with m 193o. [Mooman & Anton J Phys Chem 80 2243 1976, Beilstein 20 II 236, 20 III/IV 3410, 20/7 V 333.]

Isoquinoline Preparation Products And Raw materials

Raw materials

Preparation Products


Isoquinoline Suppliers

Global( 271)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22059 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20795 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32764 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 14297 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 20001 58
Tocopharm Co., Ltd. +86-021-69895597、+86-13776836200; QQ:739486509
+86-021-61292409 sales@tocopharm.com; info@tocopharm.com China 186 55
Shanghai YouPeng Chemical Co. Ltd. 021-69002118 ,69006118
021-69005775 youpengchem@163.com China 5183 56
Hangzhou YiDi Industrial Co., Ltd. 0571-82609104 18069800150
0571-82609104 yidipharma@163.com CHINA 98 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) sh@meryer.com China 40399 62

View Lastest Price from Isoquinoline manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-24 Isoquinoline
119-65-3
US $1.00 / kg 1kg 95%-99% as request career henan chemical co

Isoquinoline Spectrum


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