cefacetrile
- CAS No.
- 10206-21-0
- Chemical Name:
- cefacetrile
- Synonyms
- cefacetrile;Cefacetrilo;Cefacetrilum;CEPHACETRILE;Cefepime API;cefacetrile USP/EP/BP;Cefcapene Pivoxil API;Cefacetrilum [inn-latin];Cephacetrile,Cefacetrile;Cefacetrilo [inn-spanish]
- CBNumber:
- CB1934757
- Molecular Formula:
- C13H13N3O6S
- Molecular Weight:
- 339.32
- MDL Number:
- MFCD00865099
- MOL File:
- 10206-21-0.mol
| Melting point | 133-135°C |
|---|---|
| Boiling point | 757.5±60.0 °C(Predicted) |
| Density | 1.59±0.1 g/cm3(Predicted) |
| storage temp. | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
| solubility | DMF (Slightly), DMSO (Slightly), Methanol (Slightly) |
| pka | pKa 1.97 (Uncertain) |
| form | Solid |
| color | White to Pale Beige |
| Stability | Hygroscopic |
| FDA UNII | FDM21QQ344 |
| ATC code | J01DB10 |
cefacetrile price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | C231500 | Cefacetrile | 10206-21-0 | 5mg | $95 | 2021-12-16 | Buy |
| TRC | C231500 | Cefacetrile | 10206-21-0 | 25mg | $235 | 2021-12-16 | Buy |
| Usbiological | 257230 | Cefacetrile | 10206-21-0 | 5mg | $425 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0009120 | CEFACETRILE 95.00% | 10206-21-0 | 25MG | $739.2 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0009120 | CEFACETRILE 95.00% | 10206-21-0 | 250MG | $1871.1 | 2021-12-16 | Buy |
cefacetrile Chemical Properties,Uses,Production
Description
This drug is similar to cephalothin, but after intravenous administration, higher peak serum levels are attained, and its serum half-life is longer (Brogard et al., 1973a; Brogard et al., 1973b). However, cephacetrile appears to have no clinical advantages over cephalothin, as demonstrated in one comparative trial (Jackson et al., 1974). It has most recently been available in Italy.
Chemical Properties
Pale Beige Solid
Originator
Celospor,Ciba Geigy,Switz.,1969
Uses
A cephalosporin antibiotic. Antibacterial.
Definition
ChEBI: Cefacetrile is a cephalosporin.
Manufacturing Process
13.6 g (0.05 mol) of 7-aminocephalosporanic acid are taken up in a mixture
of 150 ml of methylene chloride and 19.5 ml of tributylamine (0.12 mol) and
at 0°C a solution of 8.4 g of cyanoacetylchloride (0.07 mol) in 100 ml of
methylene chloride is stirred in. The bath is then stirred for ? hour at 0°C
and for ? hour at 20°C, the reaction solution is evaporated under vacuum
and the residue taken up in 10% aqueous dipotassium hydrogenphosphate
solution. This aqueous phase is washed with ethyl acetate, acidified to pH 2.0
with concentrated hydrochloric acid and extracted with ethyl acetate.
After having been dried over sodium sulfate and evaporated under vacuum,
this extract gives as a solid residue 14.7 g of crude 7-cyanoacetylamino-cephalosporanic acid which is purified by chromatography on 30 times its own
weight of silica gel. The fractions eluted with chloroform plus acetone (7:3)
furnish a product which crystallizes from acetone plus ether in the form of
needles melting at 168° to 170°C with decomposition.
5.10 g (15 mmol) of 7-cyanoacetyl-aminocephalosporanic acid are suspended in 102 ml of distilled water and converted into the sodium salt by stirring in
dropwise 15 ml of N sodium hydroxide solution.
Therapeutic Function
Antibiotic
Antimicrobial activity
Its spectrum resembles that of cefalotin. Following an intramuscular dose of 1 g, a peak plasma concentration around 15 mg/L is achieved at 1 h. About 25% is bound to plasma protein. Penetration into the CSF is limited. About 80% of the drug is excreted in the urine, producing concentrations in excess of 1 g/L, 25% of which is in the desacetylated form. Clearance is depressed by probenecid and in renal failure. Little is excreted in the bile. Manifestations of hypersensitivity in patients not known to be allergic to β-lactam antibiotics are common. It is no longer used.
cefacetrile Preparation Products And Raw materials
Raw materials
Preparation Products
cefacetrile Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29823 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 8232 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 10991 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 | waley188@sohu.com | China | 12338 | 58 |
| PI & PI BIOTECH INC. | 020-81716320 17788709170 | Sales@pipitech.com | China | 2649 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 56086 | 58 |
View Lastest Price from cefacetrile manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-05-26 | cefacetrile
10206-21-0
|
US $0.00-0.00 / Kg | 1KG | 99.0% | 500 MT | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-12-26 | cefacetrile
10206-21-0
|
US $1.00 / g | 1g | ≥98% | g/kg/Ton | Career Henan Chemical Co |
-
- cefacetrile
10206-21-0
- US $0.00-0.00 / Kg
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
-
- cefacetrile
10206-21-0
- US $1.00 / g
- ≥98%
- Career Henan Chemical Co
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