ChemicalBook
Chinese Japanese Germany Korea

Nitrofurazone

Nitrofurazone
Nitrofurazone structure
CAS No.
59-87-0
Chemical Name:
Nitrofurazone
Synonyms
NF;NFZ;NFS;NF-7;Nefco;acutol;Amifur;Chixin;Mammex;U-6421
CBNumber:
CB0492724
Molecular Formula:
C6H6N4O4
Formula Weight:
198.14
MOL File:
59-87-0.mol

Nitrofurazone Properties

Melting point:
242-244 °C(lit.)
Boiling point:
335.43°C (rough estimate)
Density 
1.6031 (rough estimate)
refractive index 
1.6500 (estimate)
Flash point:
2 °C
storage temp. 
2-8°C
solubility 
Very slightly soluble in water, slightly soluble in ethanol (96 per cent).
form 
neat
pka
pKa 9.28± 0.03( EtOH,t =35±0.1,I=0.00) (Uncertain)
Water Solubility 
<0.1 g/100 mL at 19 ºC
Sensitive 
Light Sensitive
Merck 
14,6600
BRN 
86403
InChIKey
IAIWVQXQOWNYOU-FPYGCLRLSA-N
CAS DataBase Reference
59-87-0(CAS DataBase Reference)
NIST Chemistry Reference
5-Nitro furfural semicarbazone(59-87-0)
EPA Substance Registry System
Nitrofurazone (59-87-0)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07,GHS02,GHS06,GHS08
Signal word  Danger
Hazard statements  H302-H317-H225-H302+H312+H332-H319-H301-H341-H351-H361
Precautionary statements  P280-P301+P312+P330-P210-P305+P351+P338-P201-P301+P310a-P308+P313-P405-P501a
Hazard Codes  Xn,F
Risk Statements  22-36-20/21/22-11
Safety Statements  36-36/37-26-16
RIDADR  3249
WGK Germany  3
RTECS  LT7700000
8
TSCA  Yes
HazardClass  6.1(b)
PackingGroup  III
HS Code  29321900
Toxicity LD50 in rats (g/kg): 0.59 orally; 3.0 s.c. (Godwin)

Nitrofurazone price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 31706 Nitrofurazone solution 100 μg/mL in acetonitrile, VETRANAL , analytical standard 59-87-0 2ml $71 2019-12-02 Buy
Sigma-Aldrich 1465004 Nitrofurazone United States Pharmacopeia (USP) Reference Standard 59-87-0 200mg $352.8 2019-12-02 Buy
TCI Chemical N0200 Nitrofurazone >98.0%(HPLC)(E) 59-87-0 25g $18 2019-12-02 Buy
TCI Chemical N0200 Nitrofurazone >98.0%(HPLC)(E) 59-87-0 250g $91 2019-12-02 Buy
Alfa Aesar A18593 5-Nitro-2-furaldehyde semicarbazone, 98+% 59-87-0 25g $23.6 2019-12-02 Buy

Nitrofurazone Chemical Properties,Uses,Production

Chemical Properties

white to light yellow crystal powde

Uses

Anti-infective (topical). Antimicrobial.

Definition

ChEBI: A semicarbazone resulting from the formal condensation of semicarbazide with 5-nitrofuraldehyde. A broad spectrum antibacterial drug, although with little activity against Pseudomonas species, it is used as a local application for burns, ulcer , wounds and skin infections.

Definition

A type of organic compound containing the C:N.NH.CO.NH2 grouping, formed by reaction of an aldehyde or ketone with semicarbazide (H2N.NH.CO.NH2). The compounds are crystalline solids with sharp melting points, which can be used to characterize the original aldehyde or ketone.

brand name

Actin-N (Sherwood); Furacin (Shire);Acmor-s;Akutol;Anginofur;Auroid;Beca furazona;Bifuran;Burnazone;Dermobion;Ectofural;Escofuran;Escofuron;Fluorobioptal;Furacilinum;Furacinas;Furacinethin;Furacin-sol;Furacin-streusol;Furacocid;Furacol;Furaseptin;Fura-septin;Fura-vet;Furea;Furesan;Furotalgin;Furovol;Germax;Germex;Ginejuvent;I fomula;Ii formula;Kamfomen;Kindrog;Lifuzol;Mammiject;Mastidol;Muldacin;Neovagon;Nfz 1;Nitocetin;Nitrocol plus;Nitro-rea;Notaba;Sanifur;Scandantin;Sulfamyton-n;Taristop;Tranoxa;Tuocurine;Urafadyn;Uroletten;Viropulver;Yalrocin;Zoppin spray blu.

World Health Organization (WHO)

Nitrofural, a nitrofuran derivative with broad-spectrum antibacterial activity, was introduced in the early 1940s for the topical treatment of various skin conditions. It has also been used systemically for the treatment of African trypasonomiasis. Following recent findings of in vitro mutagenicity and of carcinogenicity in experimental animals, use of topical preparations containing this substance was restricted in Germany. Nitrofural remains registered in several countries and the World Health Organization is not aware of restrictive action having been taken elsewhere.

General Description

Odorless pale yellow needles or yellow powder. pH (saturated aqueous solution) 6.0 - 6.5. Alkaline solutions are dark orange.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Furacilin darkens on prolonged exposure to light. Furacilin can react violently with reducing materials. .

Fire Hazard

Flash point data for Furacilin are not available; however, Furacilin is probably combustible.

Pharmaceutical Applications

A synthetic compound used in the topical treatment of wounds and burns and as an instillation for bladder washout. A nitrofurazone-impregnated urinary catheter is said to reduce infection in catheterized patients. Activity against the common bacterial pathogens is sufficient to cover most pathogens that cause infections of burns and wounds, with the important exception of Ps. aeruginosa. Attention has been drawn to its activity against methicillin-resistant Staphylococcus aureus, and its use in clearing carriage has been suggested. Slight absorption occurs from intact skin (c. 1%) and burned skin (5%). It is neither a primary irritant nor a sensitizer, but some preparations contain polyethylene glycol as a vehicle, and absorption can cause problems in patients with reduced renal function. Of limited availability.

Contact allergens

Nitrofurazone is an antibacterial agent used in animal feeds. Occupational dermatitis was reported in cattle breeders or farmers.

Clinical Use

5-Nitro-2-furaldehyde semicarbazone (Furacin) occurs asa lemon-yellow crystalline solid that is sparingly solublein water and practically insoluble in organic solvents.Nitrofurazone is chemically stable, but moderately lightsensitive.It is used topically in the treatment of burns, especiallywhen bacterial resistance to other agents may be a concern.It may also be used to prevent bacterial infection associatedwith skin grafts. Nitrofurazone has a broad spectrumof activity against Gram-positive and Gram-negative bacteria,but it is not active against fungi. It is bactericidalagainst most bacteria commonly causing surface infections,including S. aureus, Streptococcus spp., E. coli,Clostridium perfringens, Enterobacter (Aerobacter) aerogenes,and Proteus spp.; however, P. aeruginosa strainsare resistant.Nitrofurazone is marketed in solutions, ointments, andsuppositories in a usual concentration of 0.2%.

Safety Profile

Poison by ingestion and intraperitoneal routes. Moderately toxic by subcutaneous route. Questionable carcinogen with experimental carcinogenic, neoplas tigenic, tumorigenic, and teratogenic data, Experimental reproductive effects. A human sensitizer. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Veterinary Drugs and Treatments

Nitrofurazone can be used topically as an antibacterial for treating or preventing superficial infections. It is a nitrofuran antibacterial that is bactericidal for many bacteria, including E. Coli, Staph aureus, etc. Nitrofurazone’s mechanism of action is thought to be associated with inhibiting bacterial enzymes that primarily degrade glucose and pyruvate.

Nitrofurazone Preparation Products And Raw materials

Raw materials

Preparation Products


Nitrofurazone Suppliers

Global( 220)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21792 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22631 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 739 60
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 569 55
Anhui Royal Chemical Co., Ltd.
+86-025-86736275
dana.jiang@royal-chem.com CHINA 511 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1892 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30057 58
Hebei Ruishun Trade Co.,LTD
17052563120
Mike@rsbiology.com CHINA 302 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23978 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 sales@jushengtech.com CHINA 28235 58

View Lastest Price from Nitrofurazone manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-24 Furacilin
59-87-0
US $7.00 / ASSAYS 1KG/Tin 99% 100KG career henan chemical co
2018-04-03 Furacilin
59-87-0
US $10.00 / G 5G 99% 10mt Hubei XinRunde Chemical Co., Ltd.
2018-08-27 Furacilin
59-87-0
US $1.00 / G 100G 99% 50000tons Hebei Ruishun Trade Co.,Ltd

Nitrofurazone Spectrum


59-87-0(Nitrofurazone)Related Search:


Copyright 2017 © ChemicalBook. All rights reserved