AM555S,TAC-101
- CAS No.
- 125973-56-0
- Chemical Name:
- AM555S,TAC-101
- Synonyms
- CS-893;AM 555S;AMsilarotene;AM555S,TAC-101;TAC 101; TAC101;AMsilarotene (TAC-101);Amsilarotene, 10 mM in DMSO;4-(3,5-bis(trimethylsilyl)benzamido)benzoic acid;4-[[3,5-Bis(trimethylsilyl)benzoyl]amino]benzoic acid;Benzoic acid,4-[[3,5-bis(trimethylsilyl)benzoyl]amino]-
- CBNumber:
- CB21011069
- Molecular Formula:
- C20H27NO3Si2
- Molecular Weight:
- 385.6
- MDL Number:
- MFCD00952173
- MOL File:
- 125973-56-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 280℃ (decomposition) |
|---|---|
| Boiling point | 403.3±45.0 °C(Predicted) |
| Density | 1.10±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : 100 mg/mL (259.34 mM; Need ultrasonic) |
| form | Solid |
| pka | 4.28±0.10(Predicted) |
| color | White to off-white |
| FDA UNII | Q1418F39MH |
| NCI Drug Dictionary | amsilarotene |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
AM555S,TAC-101 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | AFA97356 | Amsilarotene (tac-101) | 125973-56-0 | 25mg | $1096 | 2026-06-04 | Buy |
| Biosynth | AFA97356 | Amsilarotene (tac-101) | 125973-56-0 | 50mg | $1525 | 2026-06-04 | Buy |
| Biosynth | AFA97356 | Amsilarotene (tac-101) | 125973-56-0 | 100mg | $2439 | 2026-06-04 | Buy |
| ChemScene | CS-0003504 | Amsilarotene 99.67% | 125973-56-0 | 5mg | $119 | 2026-06-04 | Buy |
| ChemScene | CS-0003504 | Amsilarotene 99.67% | 125973-56-0 | 10mg | $195 | 2026-06-04 | Buy |
AM555S,TAC-101 Chemical Properties, Uses, Production
Uses
Amsilarotene (TAC-101; Am 555S), an orally active synthetic retinoid, has selective affinity for retinoic acid receptor α (RAR-α) binding with Ki of 2.4, 400 nM for RAR-α and RAR-β. Amsilarotene induces the apoptotic of human gastric cancer, hepatocellular carcinoma and ovarian carcinoma cells. Amsilarotene can be used for the research of cancer[1][2][3].
in vivo
Amsilarotene (8 mg/kg/day orally for 30 days) inhibits the RMG-II tumor growth in nude mice[2].
| Animal Model: | 6-week-old female BALB/c nu/nu mice with subcutaneous RMG-II tumors[2] |
| Dosage: | 8 mg/kg/day |
| Administration: | Orally for 30 days |
| Result: | The maximal tumor growth-inhibiting effect was seen on day 31 of administration, when there was a 45% reduction of relative tumor volume (RTV). |
References
[1] Sun SY, et al. Differential effects of synthetic nuclear retinoid receptor-selective retinoids on the growth of human non-small cell lung carcinoma cells. Cancer Res. 1997 Nov 1;57(21):4931-9. PMID:9354460
[2] Suzuki N, et al. A novel retinoid, 4-[3,5-bis (trimethylsilyl) benzamido] benzoic acid (TAC-101), induces apoptosis of human ovarian carcinoma cells and shows potential as a new antitumor agent for clear cell adenocarcinoma. Gynecol Oncol. 2004 Sep;94(3):643-9. DOI:10.1016/j.ygyno.2004.06.026
[3] Fujimoto K, et al. Induction of cell-cycle arrest and apoptosis by a novel retinobenzoic-acid derivative, TAC-101, in human pancreatic-cancer cells. Int J Cancer. 1999 May 17;81(4):637-44. DOI:10.1002/(sici)1097-0215(19990517)81:43.0.co;2-4
AM555S,TAC-101 Preparation Products And Raw materials
Raw materials
Preparation Products
AM555S,TAC-101 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4773 | 55 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2774 | 58 |
| GIHI CHEMICALS CO.,LTD | 0086-571-86217390 | Sales@gihichem.com | China | 858 | 58 |
| Credit Asia Chemical Co., Ltd. | +86 (21) 61124340 | China | 9739 | 58 | |
| Shanghaizehan biopharma technology co., Ltd. | 021-61350663 13052117465 | sales@zehanbiopharma.com | China | 989 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 18916372613 | yanzihan@shyuanye.com | China | 87240 | 60 |
| Shanghai Rechem science Co., Ltd. | 021-31433387 15618786686 | sales@rechemscience.com | China | 2965 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Nanjing crow LuNing pharmaceutical technology co., LTD | 13382066392 | CHINA | 4851 | 58 |
View Latest Price from AM555S,TAC-101 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-17 | Amsilarotene
125973-56-0
|
$36.00-143.00 | 99.27% | 10g | TargetMol Chemicals Inc. |
-
- Amsilarotene
125973-56-0
- $36.00-143.00
- 99.27%
- TargetMol Chemicals Inc.
