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(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride

(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride structure

CAS No.: 1062580-52-2

Chemical Name:: (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride

Synonyms: (3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride;TOF30;Tofacitinib-1;Tofatinib Impurity 5;Tofacitinib interMediate A;Tofacitinib intermediate 3;piperidin-3-amine dihydrochL;Tofacitinib Impurity 123 DiHCl;Azilsartan medoxomil impurity351;Tofacitinib Impurity 5 Dihydrochloride

CBNumber:: CB21011155

Molecular Formula:: C14H23ClN2

Molecular Weight:: 254.8

MDL Number:: MFCD09864744

MOL File:: Mol file

Last updated:2024-03-22 11:53:02

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(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride Properties

Melting point	249～251℃
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Aqueous Acid (Slightly), DMSO (Slightly, Heated, Sonicated), Methanol (Slightly)
form	Solid
color	White to Off-White
InChI	InChI=1/C14H22N2.ClH/c1-12-8-9-16(11-14(12)15-2)10-13-6-4-3-5-7-13;/h3-7,12,14-15H,8-11H2,1-2H3;1H/t12-,14+;/s3
InChIKey	FVRZQLQXDPJADE-WLZBWWFYNA-N
SMILES	C(C1C=CC=CC=1)N1CC[C@@H](C)[C@@H](NC)C1.Cl \|&1:10,12,r\|
FDA UNII	H9652393WE

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P264-P270-P301+P312-P330-P501
HazardClass	IRRITANT
HS Code	2933399990

(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride price More Price(20)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	D480190	(3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamineDihydrochloride	1062580-52-2	10g	$235	2021-12-16	Buy
Apolloscientific	OR54340	cis-1-Benzyl-4-methyl-3-(methylamino)piperidine dihydrochloride 95+%	1062580-52-2	25g	$311	2021-12-16	Buy
SynQuest Laboratories	3H31-5-2Q	(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-aminedihydrochloride 97.0%	1062580-52-2	1g	$490	2021-12-16	Buy
Medical Isotopes, Inc.	35378	(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-aminedHCl 95+%	1062580-52-2	1000mg	$550	2021-12-16	Buy
AK Scientific	1409AA	(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-aminedihydrochloride	1062580-52-2	1g	$72	2021-12-16	Buy

Product number	Packaging	Price	Buy
D480190	10g	$235	Buy
OR54340	25g	$311	Buy
3H31-5-2Q	1g	$490	Buy
35378	1000mg	$550	Buy
1409AA	1g	$72	Buy

(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride Chemical Properties,Uses,Production

Uses

(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production processes.

Uses

(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride is a related compound of Tofacitinib (T528000). (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride can be used to prepare janus kinase 1 selective inhibitor.

Synthesis

Synthesis_1062580-52-2
TiCl4(0.2g, 1mmol) and NEt3(0.15 g, 1.5 mmol) were added to toluene, and then add 1-benzyl-4-methyl-3-ketone piperidine (20.3 g, 100 mmol) at 35 ℃. The methylamine solution is added to the reaction solution (9.32 g, 120 mmol) and reaction for 4 h, followed by adding NaBH (OAC) 3 (0.32 g, 1.5 mmol) and glacial acetic acid 2 ml. After the reaction is complete, add saturated salt water to wash the reaction mixture. (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride was obtained after further purification.

(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride synthesis

Synthesis of (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride from (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine

(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride Preparation Products And Raw materials

Raw materials

(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine 1-BENZYL-N,4-DIMETHYLPIPERIDIN-3-AMINE DIHYDROCHLORIDE 1-benzyl-4-methylpiperidin-3-one (1-Benzyl-4-Methyl-1,2,5,6-tetrahydropyridin-3-yl)carbaMic acid Methyl ester Methanamine Acetate

3-Amino-4-methylpyridine

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Preparation Products

(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride Suppliers

Global( 349)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Changsha Junyu Chemexpress.co., Ltd	+86-13723890100	info@csjyyy.cn	China	134	58
Shanghai Boc Chemical Co., Ltd.	021-34975602; +8618721111801	shangli@bocchem.com	China	138	58
Purest Pharmaceuticl （Xi’an) Co,.LTD	+8613893405577	12829054@qq.com	China	74	58
Hangzhou ICH Biofarm Co., Ltd	+undefined8613073685410	sales@ichemie.com	China	985	58
hebei hongtan Biotechnology Co., Ltd	+86-86-1913198-3935 +8617331935328	sales03@chemcn.cn	China	951	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3012	60

Supplier	Advantage
Changsha Junyu Chemexpress.co., Ltd	58
Shanghai Boc Chemical Co., Ltd.	58
Purest Pharmaceuticl （Xi’an) Co,.LTD	58
Hangzhou ICH Biofarm Co., Ltd	58
hebei hongtan Biotechnology Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60

View Lastest Price from (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-26	(3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride 1062580-52-2	US $0.00 / kg	1kg	99%	20mt	Jinan Finer Chemical Co., Ltd
2024-04-26	(3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride 1062580-52-2	US $30.00 / kg	1kg	98%	2000kg	hebei hongtan Biotechnology Co., Ltd
2024-04-10	(3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride 1062580-52-2	US $0.00 / kg	1kg	99%	500kg	Shanghai Joiny Pharmaceutical Co.,LTD

(3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride
1062580-52-2
US $0.00 / kg
99%
Jinan Finer Chemical Co., Ltd

(3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride
1062580-52-2
US $30.00 / kg
98%
hebei hongtan Biotechnology Co., Ltd

(3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride
1062580-52-2
US $0.00 / kg
99%
Shanghai Joiny Pharmaceutical Co.,LTD

(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride Spectrum

(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride(1062580-52-2)¹HNMR

1062580-52-2((3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride)Related Search:

(1-Benzyl-4-Methyl-1,2,5,6-tetrahydropyridin-3-yl)carbaMic acid Methyl ester Methyl (1-benzyl-4-Methylpiperidin-3-yl)carbaMate 13-Deoxyepirubicin 3-((3R,4S)-4-Methyl-3-(Methyl(7H-pyrrolo[2,3-d]pyriMidin-4-yl)aMino)piperidin-1-yl)-3-oxopropanenitrile 3-METHOXYCARBONYLAMINO-4-METHYLPYRIDINE

1-[2-(2-methoxyphenoxy)ethylamino]-3-(9-methylcarbazol-4-yl)oxypropan-2-ol:hydrochloride Methyl (4-Methylpiperidin-3-yl)carbaMate 3-((3S,4R)-4-Methyl-3-(Methyl(7H-pyrrolo[2,3-d]pyriMidin-4-yl)aMino)piperidin-1-yl)-3-oxopropanenitrile 3-PiperidinaMine, 1-acetyl-N,4-diMethyl-N-1H-pyrrolo[2,3-d]pyriMidin-4-yl-, (3R,4R)- (9CI) 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine 2,4-DICHLORO-7H-PYRROLO2,3-DPYRIMIDINE 7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, N-Methyl-N-[(3R,4R)-4-Methyl-1-(phenylMethyl)-3-piperidinyl]-7-[(4-Met hylphenyl)sulfonyl]-

4-CHLORO-7-TOSYL-7H-PYRROLO[2,3-D]PYRIMIDINE Tofacitinib citrate 3-bis(4-Methylbenzoyloxy)succinate)

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CIS-N-BENZYL-3-METHYLAMINO-4-METHYL-PIPERIDINE BIS-(HYDROCHLORIDE) cis-1-Benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride cis-1-Benzyl-4-methyl-3-(methylamino)piperidine dihydrochloride 95+% cis-1-Benzyl-N3,4-dimethylpiperidin-3-amine dihydrochloride (3R,4R)-1-BENZYL-N,4-DIMETHYLPIPERIDIN-3-AMINE DIHYDROCHLORIDE (3R,4R)-1-benzyl-N,4-diMethylpiperidin-3-aMine BIS-(HYDROCHLORIDE) 3-PiperidinaMine, N,4-diMethyl-1-(phenylMethyl)-, hydrochloride (1:2), (3R,4R)- (3R,4R)-N,4-DiMethyl-1-(phenylMethyl)-3-piperidi (3R,4R)- Cis-1-benzyl-4-Methyl-3-(MethylaMino)piperidine Tofacitinib interMediate A (3R,4R)- cis-1-Benzyl-4-Methyl-3-(MethylaMino)piperidine dihydrochloride (3R,4R)-1-BENZYL-N,4-DIMETHYLPIPERIDIN-3-AMINE DIHYDROCHLORID 3-Piperidinamine, N,4-dimethyl-1-(phenylmethyl)-, dihydrochloride, (3R,4R)- Tofacitinib intermediate 3 (3R,4R)-(1-Benzyl-4-methyl-piperidin-3-yl)-methyl-amine dihydrochloride Azilsartan medoxomil impurity351 (3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydro... Tofacitinib Impurity 5 Dihydrochloride N-((3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride (3R,4R)-1-BENZYL-N,4-DIMETHYLPIPERIDIN-3-AMINE 2HCL (3R,4R)-1-BENZYL-N,4-DIMETHYLPIPERIDIN-3-AMINEDITYDROCHLORIDE Cis-n-benzyl-3-methylamino-4-methyl-piperidine bis-(, HCl ) (3R,?4R)?-N,?4-?Dimethyl-?1-?(phenylmethyl)?-3-?piperidinamine Dihydrochloride piperidin-3-amine dihydrochL (3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine, hydrochloride (1:2) Cis 1-benzyl-4-methyl-3-methylamino-piperidine hydrochloride Tofacitinib-1 TOF30 (3R,4R)-1-Benzyl-3-(methylamino)-4-methylpiperidine Dihydrochloride (3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine HCl (3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride (3R,4R)-N, 4-dimethyl-1 -(phenylmethyl) -3-piperidamine hydrochloride Tofatinib Impurity 5 (3R,4R)-N,4-Dimethy1-(phenylmethyl)-3-piperidinamine hydrochloride CIS-N-BENZYL-3-METHYLAMINO-4-METHYL-PIPERIDINE BIS-(HYDROCHLORIDE) Tofacitinib （Int.） Tofacitinib Impurity 123 DiHCl (3R,4R)-N,4-Dimethyl-1-(benzyl)-3-piperidinamine 2HCl (3R,4R)-1-Benzyl-N,4-dimethyl-3-piperidinamine dihydrochloride 1062580-52-2 C14H22N22HCl 1