ChemicalBook >> CAS DataBase List >>Doxorubicinone
Doxorubicinone
- CAS No.
- 24385-10-2
- Chemical Name:
- Doxorubicinone
- Synonyms
- Ccris 7633;ADRIAMYCINONE;Doxorubicinone;Epirubicin aglycon;adriamycinaglycone;Epirubicin aglycone;Doxorubicin aglycone;Doxorubicinone-13C-D3;Doxorubicin Hydrochloride EP Impurity D;Doxorubicin EP Impurity D/Epirubicin hydrochloride EP impurity A
- CBNumber:
- CB2121622
- Molecular Formula:
- C21H18O9
- Molecular Weight:
- 414.36
- MDL Number:
- MFCD00871832
- MOL File:
- 24385-10-2.mol
- MSDS File:
- SDS
Last updated:2024-02-02 21:55:19
| Melting point | 223-225°C |
|---|---|
| Boiling point | 741.2±60.0 °C(Predicted) |
| Density | 1.671±0.06 g/cm3(Predicted) |
| storage temp. | Amber Vial, -20°C Freezer |
| solubility | Dioxane (Slightly), DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 7.45±0.60(Predicted) |
| color | Red to Very Dark Red |
| Stability | Light Sensitive |
| InChI | InChI=1S/C21H18O9/c1-30-11-4-2-3-8-14(11)20(28)16-15(17(8)25)18(26)9-5-21(29,12(24)7-22)6-10(23)13(9)19(16)27/h2-4,10,22-23,26-27,29H,5-7H2,1H3/t10-,21-/m0/s1 |
| InChIKey | IBZGBXXTIGCACK-CWKPULSASA-N |
| SMILES | C1(OC)=C2C(C(=O)C3=C(C2=O)C(O)=C2C(C[C@@](O)(C(CO)=O)C[C@@H]2O)=C3O)=CC=C1 |
| CAS DataBase Reference | 24385-10-2 |
| FDA UNII | X023T6C35L |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H311-H350-H340-H331-H360-H301 | |||||||||
| Precautionary statements | P280-P302+P352-P312-P322-P361-P363-P405-P501-P264-P270-P301+P310-P321-P330-P405-P501-P261-P271-P304+P340-P311-P321-P403+P233-P405-P501 | |||||||||
| HS Code | 29147000 | |||||||||
| NFPA 704 |
|
Doxorubicinone price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 21693 | Doxorubicinone ≥98% | 24385-10-2 | 500μg | $68 | 2024-03-01 | Buy |
| Cayman Chemical | 21693 | Doxorubicinone ≥98% | 24385-10-2 | 1mg | $130 | 2024-03-01 | Buy |
| Cayman Chemical | 21693 | Doxorubicinone ≥98% | 24385-10-2 | 5mg | $601 | 2024-03-01 | Buy |
| Cayman Chemical | 21693 | Doxorubicinone ≥98% | 24385-10-2 | 10mg | $1031 | 2024-03-01 | Buy |
| TRC | D559070 | Doxorubicinone | 24385-10-2 | 50mg | $1390 | 2021-12-16 | Buy |
Doxorubicinone Chemical Properties,Uses,Production
Description
Doxorubicinone is a metabolite of the anthracycline antitumor antibiotic doxorubicin . Doxorubicinone inhibits mitochondrial succinoxidase from bovine heart and reduces the mitochondrial inner membrane potential in rat heart and liver mitochondria in a concentration-dependent manner. Doxorubicinone (40 μM) increases pentose phosphate pathway flux by 45% and reduces activity of glutathione peroxidase (GPx) and superoxide dismutase (SOD) by 17 and 60%, respectively, in human erythrocytes. It also induces cytotoxicity in patient-derived ovarian cancer colonies in a concentration-dependent manner.
Chemical Properties
Red Solid
Uses
A metabolite of Doxorubicin (Dx).
Definition
ChEBI: Adriamycinone is a member of tetracenes and a quinone.
General Description
Doxorubicinone (adriamycinone) is an aglycone. It is a metabolite of adriamycin converted in the body, and another metabolite is amycinol [1]. Adriamycin nephropathy (AN) is a rodent model of chronic kidney disease. AN is characterized by podocyte injury followed by glomerulosclerosis, tubulointerstitial inflammation and fibrosis.
References
[1] Emara S, et al. Effect of cyclodextrins on the stability of adriamycin, adriamycinol, adriamycinone and daunomycin. Talanta, 2008; 51: 359-364.
Doxorubicinone Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 64)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| R&D Scientific Inc. | +12266000236 | sales@rdscientific.com | Canada | 1245 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 | info@afinechem.com | CHINA | 15377 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178 +86-85511178 | peter68@ptchemgroup.com | China | 35453 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49999 | 58 |
View Lastest Price from Doxorubicinone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-02-02 | Doxorubicinone
24385-10-2
|
US $2200.00 / g | 1g | 98 | 5 Kg | R&D Scientific Inc. |
-
- Doxorubicinone
24385-10-2
- US $2200.00 / g
- 98
- R&D Scientific Inc.
24385-10-2(Doxorubicinone)Related Search:
Epirubicin aglycon
5,12-Naphthacenedione, 7,8,9,10-tetrahydro-6,8,10,11-tetrahydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S-cis)-
Ccris 7633
8-glycoloyl-7,8,9,10-tetrahydro-6,8,10,11-tetrahydroxy-1-methoxy-5,12-Naphthacenedione
Doxorubicin aglycone
Doxorubicinone
Epirubicin aglycone
5,12-Naphthacenedione, 7,8,9,10-tetrahydro-6,8,10,11-tetrahydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S,10S)-
7,8,9,10-Tetrahydro-6,8,10,11-tetrahydroxy-8-(hydroxy acetyl)-1-methoxy-(8S-cis)-5,12-naphthacenedione
ADRIAMYCINONE
(8S,10S)-7,8,9,10-Tetrahydro-6,8,10,11-tetrahydroxy 8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione
adriamycinaglycone
Doxorubicinone (Doxorubicin EP Impurity D,Epirubicin EP Impurity A)
5,12-Naphthacenedione, 7,8,9,10-tetrahydro-6,8,10,11-tetrahydroxy-8-(2-hydroxyacetyl)-1-methoxy-, (8S,10S)-
Doxorubicin Hydrochloride EP Impurity D
Doxorubicinone-13C-D3
DoxorubicinoneQ: What is
Doxorubicinone Q: What is the CAS Number of
Doxorubicinone Q: What is the storage condition of
Doxorubicinone Q: What are the applications of
Doxorubicinone
Doxorubicinone ((8S,10S)-6,8,10,11-Tetrahydroxy-8-(hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetr (1225758)
(8S,10S)-6,8,10,11-tetrahydroxy-8-(hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione (doxorubicin aglycone, doxorubicinone).
(8S,10S)-10[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-8-(bromoacetyl)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione,
Doxorubicin EP Impurity D/Epirubicin hydrochloride EP impurity A
24385-10-2
C21H18O9
Intermediates & Fine Chemicals
Pharmaceuticals
Metabolites & Impurities
Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals