satratoxin G
- CAS No.
- 53126-63-9
- Chemical Name:
- satratoxin G
- Synonyms
- C028268;satratoxin G;Isosatratoxin g;2',3'-Oxy-2',3'-dihydrosatratoxin H;Spiro[10,12:19,22a-dimethano-4H,5H,22aH-oxireno[8,9][1,6,12]trioxacyclooctadecino[3,4-d][1]benzopyran-11(10H),2'-oxirane]-2,14(1aH,19H)-dione, 6,8a,11a,12,21,22-hexahydro-23-hydroxy-19-(1-hydroxyethyl)-7,11a-dimethyl-
- CBNumber:
- CB21391479
- Molecular Formula:
- C29H36O10
- Molecular Weight:
- 544.59
- MDL Number:
- MFCD01684361
- MOL File:
- 53126-63-9.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P321-P330-P362+P364-P501 | |||||||||
| NFPA 704 |
|
satratoxin G price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 9003415 | Satratoxin G | 53126-63-9 | 500μg | $121 | 2024-03-01 | Buy |
| Cayman Chemical | 9003415 | Satratoxin G | 53126-63-9 | 5mg | $1024 | 2024-03-01 | Buy |
| Cayman Chemical | 9003415 | Satratoxin G | 53126-63-9 | 1mg | $218 | 2024-03-01 | Buy |
satratoxin G Chemical Properties,Uses,Production
Biological Activity
Satratoxin G is a macrocyclic trichothecene mycotoxin that has been found in S. chartarum.1,2 It induces cleavage of caspase-3 and poly(ADP-ribose) polymerase (PARP) in HL-60 cells when used at a concentration of 40 nM and is cytotoxic to HepG2, Hep-2, Caco-2, A204, U937, and Jurkat cells (IC50s = 2.2-9.7 ng/ml).3,4 Intranasal administration of satratoxin G (500 μg/kg) induces apoptosis of olfactory sensory neurons in olfactory epithelium and ethmoid turbinate expression of the genes encoding IL-1α, IL-1β, IL-6, TNF-α, and MIP-2 in mice.2 Satratoxin G induces lethality in 4 week-old male mice (LD50 = 1.23 mg/kg, i.p.).1
References
|1. Yoshizawa, T., Ohtsubo, K., Sasaki, T., et al. Acute toxicities of satratoxins G and H in mice--a histopathological observation with special reference to the liver injury caused by satratoxin G. Proc. Jpn. Assoc. Mycotoxicol. 23, 53-57 (1986).|2. Islam, Z., Harkema, J.R., and Pestka, J.J. Satratoxin G from the black mold Stachybotrys chartarum evokes olfactory sensory neuron loss and inflammation in the murine nose and brain. Environ. Health Perspect. 114(7), 1099-1107 (2006).|3. Nagase, M., Shiota, T., Tsushima, A., et al. Molecular mechanism of satratoxin-induced apoptosis in HL-60 cells: Activation of caspase-8 and caspase-9 is involved in activation of caspase-3. Immunol. Lett. 84(1), 23-27 (2002).|4. Nielsen, C., Casteel, M., Didier, A., et al. Trichothecene-induced cytotoxicity on human cell lines. Mycotoxin Res. 25(2), 77-84 (2009).
satratoxin G Preparation Products And Raw materials
Raw materials
Preparation Products
satratoxin G Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
| ChemeGen 中国 | 18818260767 | sales@chemegen.com | China | 6975 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 58 |
| ChemeGen 中国 | 58 |