AZD8931
- CAS No.
- 848942-61-0
- Chemical Name:
- AZD8931
- Synonyms
- CS-368;AZD8931;Sapitinib;AZD8931, >=96%;AZD8931 USP/EP/BP;Sapitinib(AZD8931);AZD8931 (Sapitinib);AZD-8931;AZD8931;AZD 8931;AZD8931 (SAPITINIB);AZD 8931;2-[4-({4-[(3-Chloro-2-fluorophenyl)amino]-7-methoxy-6-quinaz...
- CBNumber:
- CB22518215
- Molecular Formula:
- C23H25ClFN5O3
- Molecular Weight:
- 473.93
- MDL Number:
- MFCD18385011
- MOL File:
- 848942-61-0.mol
| Boiling point | 632.8±55.0 °C(Predicted) |
|---|---|
| Density | 1.339 |
| storage temp. | Store at -20°C |
| solubility | ≥23.7 mg/mL in DMSO; insoluble in H2O; ≥57.8 mg/mL in EtOH with gentle warming |
| form | solid |
| pka | 16.17±0.46(Predicted) |
| FDA UNII | 3499328002 |
| NCI Drug Dictionary | sapitinib |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H360-H302-H372 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501-P260-P264-P270-P314-P501 | |||||||||
| NFPA 704 |
|
AZD8931 price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 24196 | AZD 8931 ≥98% | 848942-61-0 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 24196 | AZD 8931 ≥98% | 848942-61-0 | 5mg | $140 | 2024-03-01 | Buy |
| Cayman Chemical | 24196 | AZD 8931 ≥98% | 848942-61-0 | 10mg | $235 | 2024-03-01 | Buy |
| Cayman Chemical | 24196 | AZD 8931 ≥98% | 848942-61-0 | 25mg | $533 | 2024-03-01 | Buy |
| ApexBio Technology | A8375 | AZD8931(Sapitinib) | 848942-61-0 | 50mg | $599 | 2021-12-16 | Buy |
AZD8931 Chemical Properties,Uses,Production
Uses
AZD8931 is a novel potent reversible small molecule epidermal growth factor receptor, ERBB2 (HER2) and ERBB3 inhibitor with an IC50 of 4, 3, 4 nM, respectively.
Definition
ChEBI: A member of the class of quinazolines that is 4-amino-7-methoxyquinazoline in which the amino group has been substituted by a 3-chloro-2-fluorophenyl group and in which position 6 of the quinoline ring has been substituted by a {1-[2-(methylamino)-2-oxoeth l]piperidin-4-yl}oxy group. Sapitinib is a dual tyrosine kinase inhibitor (TKI) of epithelial growth factor receptors (EGFR) HER2 and HER3.
Enzyme inhibitor
This signal transduction kinase inhibitor (FW = 473.94 g/mol; CAS 848942-61-0), also named 2-(4-[4-(3-chloro-2-fluorophenylamino)-7- methoxyquinazolin-6-yloxy]piperidin-1-yl)-N-methylacetamide, reversibly inhibits EGFR (IC50 = 4 nM), erbB2 (IC50 = 3 nM), and erbB3 (IC50 = 4 nM) phosphorylation in cells. In proliferation assays, AZD8931 is significantly more potent than gefitinib or lapatinib in specific squamous cell carcinoma of the head and neck and non-small cell lung carcinoma cell lines. In vivo, AZD8931 inhibits xenograft growth in a range of models, while significantly affecting EGFR, erbB2, and erbB3 phosphorylation and downstream signaling pathways, apoptosis, and proliferation. In EGF and HRG ligand-driven cell systems, AZD8931 is more potent than gefitinib or lapatinib. Metabolic disposition of AZD8931.
target
ErbB2
AZD8931 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-519-519-85557386 | marketing1@neostarunited.com | China | 8349 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10326 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29016 | 58 |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9338 | 58 |
| Baoji Guokang Healthchem co.,ltd | +8615604608665 15604608665 | dominicguo@gk-bio.com | CHINA | 9427 | 58 |
View Lastest Price from AZD8931 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-10-09 | AZD8931
848942-61-0
|
US $0.00 / kg | 1kg | 0.99 | 20tons | Hebei Yanxi Chemical Co., Ltd. | |
 |
2021-07-13 | Sapitinib
848942-61-0
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-07-10 | Sapitinib
848942-61-0
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |