7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol
- CAS No.
- 440122-66-7
- Chemical Name:
- 7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol
- Synonyms
- WAY 200070;WAY200070;WAY 200070;7-bromo-2-(4-hydroxyphenyl)-5-benzoxazolol;5-Benzoxazolol, 7-bromo-2-(4-hydroxyphenyl)-;7-Bromo-2-(4-hydroxyphenyl)benzo[d]oxazol-5-ol;7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol;Estrogen Receptor/ERR,WAY200070,WAY-200070,Inhibitor,inhibit
- CBNumber:
- CB22518907
- Molecular Formula:
- C13H8BrNO3
- Molecular Weight:
- 306.11
- MDL Number:
- MFCD16618385
- MOL File:
- 440122-66-7.mol
Boiling point | 463.6±35.0 °C(Predicted) |
---|---|
Density | 1.720±0.06 g/cm3(Predicted) |
storage temp. | Store at RT |
solubility | DMSO: ≥20mg/mL |
form | solid |
pka | 7.26±0.40(Predicted) |
color | White to off-white |
FDA UNII | LK94JP5JT7 |
7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol price More Price(24)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | W1520 | WAY-200070 ≥98% (HPLC) | 440122-66-7 | 5mg | $115 | 2024-03-01 | Buy |
Sigma-Aldrich | W1520 | WAY-200070 ≥98% (HPLC) | 440122-66-7 | 25mg | $441 | 2024-03-01 | Buy |
Alfa Aesar | J67375 | WAY-200070 | 440122-66-7 | 10mg | $204 | 2023-06-20 | Buy |
Cayman Chemical | 23323 | WAY-200070 ≥98% | 440122-66-7 | 5mg | $72 | 2024-03-01 | Buy |
Cayman Chemical | 23323 | WAY-200070 ≥98% | 440122-66-7 | 10mg | $134 | 2024-03-01 | Buy |
7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol Chemical Properties,Uses,Production
Uses
WAY 200070 is an aryl diphenolic azole and a selective ERβ agonist. This compound is suitable for estrogen receptor signaling research.
Biological Activity
WAY-200070 is a selective estrogen receptor agonist with IC50 of 2.3 nM.
in vivo
Administration of WAY-200070 (30 mg/kg sc) causes nuclear translocation of ERRβ receptors in WT mice. Administration of it produces a delayed 50% increase in dopamine in the striatum of wild type mice. It reduces immobility time in the mouse tail suspension test indicating an antidepressant-like effect. In gonadally intact male and female mice WAY-200070 increases agonistic behaviors such as pushing down and aggressive grooming, while leaving attacks unaffected. Ovariectomized (ovx) mice treated with PPT fail to learn the socially acquired preference, while WAY-200070-treated ovx mice shows a two-fold prolonged preference for the food eaten by their demonstrator. WAY-200070 , shows significantly decreased anxiety-like behaviors in both the open-field and elevated plus maze and significantly less depressive-like behaviors in the forced swim test.
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target
IC50: 2.3 nM (ERRβ), 155 nM (ERRα)
7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30250 | 58 |
ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23555 | 58 |
Chemsigma International Co., Ltd. | +86-18136843612 +86-19951791336 | info@chemsigma.com | China | 1342 | 58 |
Wuhan Nutra Biotechnology Co.,Ltd | +8617786394783 | nutrabiotech@outlook.com | China | 300 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
Wuhan senwayer century chemical Co.,Ltd | +undefined-27-86652399 +undefined13627115097 | market02@senwayer.com | China | 905 | 58 |
ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
View Lastest Price from 7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-18 | WAY 200070
440122-66-7
|
US $1300.00-11000.00 / gram | 10gram | 99% | 2 tons | Wuhan Senwayer Century Chemical Co.,Ltd | ||
2021-12-17 | WAY-200070
440122-66-7
|
US $100.00 / g | 1mg | 99% | 100g 10kgs | Wuhan Nutra Biotechnology Co.,Ltd |
- WAY 200070
440122-66-7
- US $1300.00-11000.00 / gram
- 99%
- Wuhan Senwayer Century Chemical Co.,Ltd
- WAY-200070
440122-66-7
- US $100.00 / g
- 99%
- Wuhan Nutra Biotechnology Co.,Ltd
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