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Raloxifene hydrochloride

Raloxifene hydrochloride
Raloxifene hydrochloride structure
CAS No.
82640-04-8
Chemical Name:
Raloxifene hydrochloride
Synonyms
CS-127;ly156758;KEOXIFENE;LY 139481;AKOS 92138;RALOXIFENE HCL;LY156758 hydrochloride;LY139481 hydrochloride;Latilavir secondary VI;Evista (Raloxifene HCl)
CBNumber:
CB6302366
Molecular Formula:
C28H28ClNO4S
Formula Weight:
510.04
MOL File:
82640-04-8.mol

Raloxifene hydrochloride Properties

Melting point:
250-253°C
storage temp. 
2-8°C
solubility 
DMSO: 28 mg/mL, soluble
form 
solid
color 
light yellow
λmax
286nm(lit.)
Merck 
14,8098
InChIKey
BKXVVCILCIUCLG-UHFFFAOYSA-N
CAS DataBase Reference
82640-04-8(CAS DataBase Reference)
FDA UNII
4F86W47BR6
NCI Dictionary of Cancer Terms
raloxifene hydrochloride
NCI Drug Dictionary
raloxifene hydrochloride
SAFETY
  • Risk and Safety Statements
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  22-24/25
WGK Germany  3
RTECS  PC4956925
HS Code  2934990002

Raloxifene hydrochloride price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR1852 Raloxifene hydrochloride for peak identification Pharmaceutical Secondary Standard; Certified Reference Material 82640-04-8 500mg $129 2021-03-22 Buy
Sigma-Aldrich 1598201 Raloxifene hydrochloride 82640-04-8 200mg $366 2020-08-18 Buy
Cayman Chemical 27189 Raloxifene (hydrochloride) ≥98% 82640-04-8 50 mg $534 2021-03-22 Buy
Cayman Chemical 10011620 Raloxifene (hydrochloride) ≥98% 82640-04-8 50mg $25 2021-03-22 Buy
Cayman Chemical 10011620 Raloxifene (hydrochloride) ≥98% 82640-04-8 100mg $48 2021-03-22 Buy

Raloxifene hydrochloride Chemical Properties,Uses,Production

Description

Raloxifene was launched as Evista in the US for the prevention of postmenopausal osteoporosis. It is noteworthy that this molecule was formerly under development as keoxifene for breast cancer and prostatic hypertrophy. Raloxifene can be prepared by acylation of 6-methoxy-2-(4-methoxyphenyl) benzothiophene followed by simultaneous demethylation of both methoxy groups. Raloxifen is a selective estrogen receptor modulator, exerting antiestrogenic action on certain tissues (breast) and also estrogenic action on bone metabolism or serum lipids. In normal early postmenopausal women, 200 mg daily produced a trend towards suppression of estrogen effects. Raloxifen impeded bone loss in osteoporosis. A two-year study in postmenopausal women with an increased risk for osteoporosis showed that Raloxifen markedly prevented non-traumatic vertebral fractures. Results of several clinical studies demonstrated that Raloxifen appreciably reduced the risk of developing breast cancer. Moreover, it had favourable effect on lipid profiles without having the potential side-effects of estrogen-based therapies. Several extensions for different uses of this molecule are planned, for example growth disorder, obesity, colon tumor and skin atrophy. No serious drug-related events have been reported in the limited number of clinical trials.

Chemical Properties

Light-Yellow Solid

Originator

Lilly (US)

Uses

Raloxifene hydrochloride can be used as a nonsteroidal, selective estrogen receptor modulator (SERM). Antiosteoporotic.

Uses

amino acid, nutrient

Uses

Labeled Raloxifene, intended for use as an internal standard for the quantification of Raloxifene by GC- or LC-mass spectrometry.

Definition

ChEBI: A hydrochloride salt resulting from the reaction of equimolar amounts of raloxifene and hydrogen chloride.

brand name

Evista (Lilly).

Raloxifene hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products


Raloxifene hydrochloride Suppliers

Global( 331)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
15327141851 027-81302090
027-81302088 2851686515@qq.com CHINA 280 58
Shanghai Worldyang Chemical Co.,Ltd.
+86-13651600618
CHINA 832 58
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
18007166089 86-18007166089
circlepowder01@gmail.com CHINA 230 58
Baoji Guokang Bio-Technology Co., Ltd.
09173909592
09173909592 cngksw@aliyun.com CHINA 9446 58
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 21022 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8882 55
Guangzhou PI PI Biotech Inc
+8618371201331
020-81716319 sales@pipitech.com;87478684@qq.com China 3245 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29959 58
Nanjing Dolon Biotechnology Co.,Ltd.
18905173768
sales@dolonchem.com CHINA 2972 58

View Lastest Price from Raloxifene hydrochloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-10-27 Raloxifene HCL
US $0.00 / KG 100g 98%+ 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
2021-10-27 Raloxifene hydrochloride
82640-04-8
US $0.00 / KG 100g 98%+ 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
2021-10-20 Raloxifene hydrochloride
82640-04-8
US $10.00 / KG 500g 99% 2000MT/Month Wuhan wingroup Pharmaceutical Co., Ltd

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