TFA-ap-dC
- CAS No.
- 115899-38-2
- Chemical Name:
- TFA-ap-dC
- Synonyms
- TFA-ap-dC;5-TFA-ap-dC;5-TFA-ap-2-Deoxycytidine;5-TFA-ap-2'-deoxycytidine;2'-Deoxy-5-[3-[(trifluoroacetyl)amino]-1-propynyl]cytidine;5-[3-(2,2,2-trifluoroacetamido)-prop-1-ynyl]-2'-deoxycytidine;2'-Deoxy-5-[3-[(trifluoroacetyl)amino]-1-propyn-1-yl]-cytidine;Cytidine, 2'-deoxy-5-[3-[(trifluoroacetyl)amino]-1-propynyl]...;05-[3-(2,2,2-trifluoroa cetamido)-prop-1-yn yl]-2'-deoxycytidine;Cytidine, 2'-deoxy-5-[3-[(trifluoroacetyl)amino]-1-propyn-1-yl]-
- CBNumber:
- CB22614115
- Molecular Formula:
- C14H15F3N4O5
- Molecular Weight:
- 376.29
- MDL Number:
- MFCD28134647
- MOL File:
- 115899-38-2.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| TFA-ap-dC | 5127CV | 250mg | $193 |
| TFA-ap-dC 97% | P000083630 | 1g | $220 |
| TFA-ap-dC 97% | AS112077 | 100mg | $298 |
| TFA-ap-dC | 5127CV | 1g | $384 |
| TFA-ap-dC 97% | AS112077 | 250mg | $495 |
TFA-ap-dC price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AK Scientific | 5127CV | TFA-ap-dC | 115899-38-2 | 250mg | $193 | 2021-12-16 | Buy |
| Ark Pharm | P000083630 | TFA-ap-dC 97% | 115899-38-2 | 1g | $220 | 2021-12-16 | Buy |
| Activate Scientific | AS112077 | TFA-ap-dC 97% | 115899-38-2 | 100mg | $298 | 2021-12-16 | Buy |
| AK Scientific | 5127CV | TFA-ap-dC | 115899-38-2 | 1g | $384 | 2021-12-16 | Buy |
| Activate Scientific | AS112077 | TFA-ap-dC 97% | 115899-38-2 | 250mg | $495 | 2021-12-16 | Buy |
TFA-ap-dC Chemical Properties,Uses,Production
Synthesis
14719-21-2
611-53-0
115899-38-2
Under argon protection, 5-iodo-2'-deoxycytidine (10 g, 28.32 mmol) was dissolved in DMF (200 mL) in a light protected round bottom flask. CuI (1.08 g, 5.67 mmol), triethylamine (7.80 mL, 55.60 mmol), 2,2,2-trifluoro-N-(prop-2-yn-1-yl)acetamide (12.8 g, 84.76 mmol), and Pd(PPh3)4 (3.27 g, 2.83 mmol) were added sequentially. The reaction mixture was stirred at room temperature for 18 hours. Subsequently, sodium bicarbonate (20 mg) was added and stirring was continued for 1 hour. After completion of the reaction, the crude product was obtained by filtration under reduced pressure and concentration to remove the volatile solvent. Purification by silica gel fast column chromatography (elution gradient: CH2Cl2, CH2Cl2:EtOAc 1:1, EtOAc:MeOH 9:1) afforded the target compound N-(3-(4-amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuryl-2- yl)-2-oxo-1,2-dihydropyrimidin-5-yl)propane- 2-yn-1-yl)-2,2,2-trifluoroacetamide (7) as a beige solid in quantitative yield.1H NMR (D2O) δ 2.24-2.17 (m, 1H, H-2'), 2.41-2.37 (m, 1H, H-2'), 3.68 (dd, J = 12.5, 5.0 Hz, 1H, H-5'), 3.77 (dd, J = 12.5, 3.2 Hz, 1H, H-5'), 3.99 (m, 1H, H-4'), 4.27 (s, 2H, CH2N), 4.34 (m, 1H, H-3'), 6.11 (t, J = 6.3 Hz, 1H, H-1'), 8.1 (br s, 1H, NH); MS (ES): m/z (%) (M-H) 375 (100).
References
[1] Patent: EP2607369, 2015, B1. Location in patent: Paragraph 0138
[2] Chemical Communications, 2005, # 36, p. 4551 - 4553
[3] Patent: WO2016/182984, 2016, A1. Location in patent: Paragraph 00140
[4] Journal of the American Chemical Society, 2005, vol. 127, # 43, p. 15071 - 15082
[5] Patent: CN104693258, 2017, B. Location in patent: Paragraph 0088; 0094; 0095
TFA-ap-dC Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
TFA-ap-dC Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9636 | 58 |
| Finetech Industry Limited | +86-27-8746-5837 +8619945049750 | info@finetechnology-ind.com | China | 9629 | 58 |
| Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 +86-13986145403; | info@fortunachem.com | China | 5991 | 58 |
| NewCan Biotech Limited | +86-0571-86912261 +8613735419629 | sales@newcanbio.com | China | 9985 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| Wuhu Nuowei chemistry Co., Ltd. | +86-0553-2911116-802 +86-18055326116 | sales1@nuowei-chem.com | China | 1627 | 58 |
| Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +8618829768577 | gao490372054@gamil.com | China | 1249 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| Henan Aochuang Chemical Co.,Ltd. | +86-0371-63689365 +8618638391208 | sales@aochuangchem.com | China | 9307 | 58 |
View Lastest Price from TFA-ap-dC manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-12-11 | TFA-ap-dC
115899-38-2
|
US $0.00-0.00 / g | 1g | 98%min | 1000g | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2025-09-23 | TFA-ap-dC
115899-38-2
|
US $0.00-0.00 / G | 1G | 98% | 2000 | Shenzhen Nexcon Pharmatechs Ltd. | |
 |
2025-04-04 | TFA-ap-dC
115899-38-2
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
