bis-2-(5-PhenylacetMido-1,2,4-Thiadiazol-2-yl)Ethyl Sulfide
- CAS No.
- 314045-39-1
- Chemical Name:
- bis-2-(5-PhenylacetMido-1,2,4-Thiadiazol-2-yl)Ethyl Sulfide
- Synonyms
- BPTES;CS-1542;BPTES, 10 mM in DMSO;Glutaminase Inhibitor II;Glutaminase Inhibitor II, BPTES;Glutaminase,inhibit,Inhibitor,BPTES;bis-2-(5-phenylaQtMido-1,2,4-Thiadiazol-2-yl)Ethylsulfide;bis-2-(5-PhenylacetMido-1,2,4-Thiadiazol-2-yl)Ethyl Sulfide;Bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide;N,N'-[Thiobis(2,1-ethanediyl-1,3,4-thiadiazole-5,2-diyl)]bisbenzeneacetamide
- CBNumber:
- CB22654238
- Molecular Formula:
- C24H24N6O2S3
- Molecular Weight:
- 524.68
- MDL Number:
- MFCD01079848
- MOL File:
- 314045-39-1.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| BPTES ≥95% (HPLC) | SML0601 | 5mg | $156 |
| BPTES ≥95% (HPLC) | SML0601 | 25mg | $614 |
| Glutaminase Inhibitor II, BPTES - CAS 314045-39-1 - Calbiochem | 5.30030 | 10mg | $261 |
| BPTES ≥95% | 19284 | 1mg | $32 |
| BPTES ≥95% | 19284 | 5mg | $86 |
| More product size | |||
| Density | 1.420±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | 2-8°C |
| solubility | DMSO: soluble10mg/mL, clear |
| pka | 9.13±0.50(Predicted) |
| form | powder |
| color | white to beige |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. |
| InChIKey | HBFNKZVNDOYJDJ-UHFFFAOYSA-N |
| SMILES | S(CCN1CN=C(NC(=O)CC2=CC=CC=C2)S1)CCN1CN=C(NC(=O)CC2=CC=CC=C2)S1 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2934999090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
bis-2-(5-PhenylacetMido-1,2,4-Thiadiazol-2-yl)Ethyl Sulfide price More Price(32)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0601 | BPTES ≥95% (HPLC) | 314045-39-1 | 5mg | $156 | 2026-03-19 | Buy |
| Sigma-Aldrich | SML0601 | BPTES ≥95% (HPLC) | 314045-39-1 | 25mg | $614 | 2026-03-19 | Buy |
| Sigma-Aldrich | 5.30030 | Glutaminase Inhibitor II, BPTES - CAS 314045-39-1 - Calbiochem | 314045-39-1 | 10mg | $261 | 2026-03-19 | Buy |
| Cayman Chemical | 19284 | BPTES ≥95% | 314045-39-1 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 19284 | BPTES ≥95% | 314045-39-1 | 5mg | $86 | 2024-03-01 | Buy |
bis-2-(5-PhenylacetMido-1,2,4-Thiadiazol-2-yl)Ethyl Sulfide Chemical Properties,Uses,Production
Description
BPTES (314045-39-1) is a potent and selective allosteric1 inhibitor of kidney-type glutaminase (GLS1), IC50 = 3.3 μM2. Selective for GLS1 over GLS2, g-glutamyl transpeptidase and glutamate dehydrogenase. Shuts down an alternative energy-generating glutaminolysis pathway in P493 cells under both glucose deprivation or hypoxia.3 Reduces the growth of P493 cell xenografts by 50% over a 10 day treatment.4 BPTES inhibition of glutamine utilization in cancer cells increases PD-L1 expression.5 Clears senescent cells and improves various age-related disorders in a geriatric mouse model.6
Uses
Bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide (BPTES) has been used as a glutaminase inhibitor.
Biochem/physiol Actions
Vaccinia virus (VACV) requires glutamine metabolism for its optimal replication. Inhibition of glutaminolysis by bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide (BPTES) can be a potential method to treat poxvirus infections.
in vivo
BPTES-NPs (BPTES nanoparticles, 1.2 mg BPTES in 100 μL nanoparticles, i.v.) significantly attenuates tumor growth in the patient-derived pancreatic orthotopic tumor model[1].
storage
Store at -20°C
References
[1] BYRON DELABARRE*. Full-Length Human Glutaminase in Complex with an Allosteric Inhibitor[J]. Biochemistry Biochemistry, 2011, 50 50: 10764-10770. DOI:10.1021/bi201613d
[2] KRUPA SHUKLA. Design, Synthesis, and Pharmacological Evaluation of Bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl Sulfide 3 (BPTES) Analogs as Glutaminase Inhibitors[J]. Journal of Medicinal Chemistry, 2012, 55 23: 10551-10563. DOI:10.1021/jm301191p
[3] ANNE LE. Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells.[J]. Cell metabolism, 2012, 15 1: 110-121. DOI:10.1016/j.cmet.2011.12.009
[4] YAN XIANG. Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis.[J]. The Journal of clinical investigation, 2015: 2293-2306. DOI:10.1172/jci75836
[5] JUN-KYU BYUN. Inhibition of Glutamine Utilization Synergizes with Immune Checkpoint Inhibitor to Promote Antitumor Immunity.[J]. Molecular Cell, 2020: 592-606.e8. DOI:10.1016/j.molcel.2020.10.015
[6] CHRISTOPHER PAN Jason W L. Targeting metabolism to influence aging[J]. Science, 2021, 371 6526. DOI:10.1126/science.abf6368
bis-2-(5-PhenylacetMido-1,2,4-Thiadiazol-2-yl)Ethyl Sulfide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 965 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29795 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32467 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9984 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39040 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
View Lastest Price from bis-2-(5-PhenylacetMido-1,2,4-Thiadiazol-2-yl)Ethyl Sulfide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-13 | BPTES
314045-39-1
|
US $31.00-63.00 / mg | 99.53% | 10g | TargetMol Chemicals Inc. | ||
 |
2020-02-19 | bis-2-(5-PhenylacetMido-1,2,4-Thiadiazol-2-yl)Ethyl Sulfide
314045-39-1
|
US $3.00 / KG | 1KG | 98% | 200KG | Career Henan Chemical Co |
-
- BPTES
314045-39-1
- US $31.00-63.00 / mg
- 99.53%
- TargetMol Chemicals Inc.
-
- bis-2-(5-PhenylacetMido-1,2,4-Thiadiazol-2-yl)Ethyl Sulfide
314045-39-1
- US $3.00 / KG
- 98%
- Career Henan Chemical Co
