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Cantharidin

Description References
Cantharidin
Cantharidin structure
CAS No.
56-25-7
Chemical Name:
Cantharidin
Synonyms
Canthari;7aalpha)-t;Cantharone;Kantaridin;Antharidin;CANTHARIDIN;cantharides;Kantharidin;7aalpha)-bet;Cantharidine
CBNumber:
CB0710248
Molecular Formula:
C10H12O4
Formula Weight:
196.2
MOL File:
56-25-7.mol

Cantharidin Properties

Melting point:
215-217 °C(lit.)
Boiling point:
253.08°C (rough estimate)
Density 
1.0357 (rough estimate)
refractive index 
1.4699 (estimate)
storage temp. 
Store at RT
solubility 
Soluble in DMSO (25 mg/ml warm), acetone (8 mg/ml), ethanol (8 mg/ml warm), chloroform (1:65), ether (1:560), and ethyl acetate (1:150).
form 
solution
color 
white
Merck 
14,1752
InChIKey
DHZBEENLJMYSHQ-XCVPVQRUSA-N
CAS DataBase Reference
56-25-7(CAS DataBase Reference)
NIST Chemistry Reference
Cantharidin(56-25-7)
EPA Substance Registry System
4,7-Epoxyisobenzofuran- 1,3-dione, hexahydro-3a,7a-dimethyl-, (3aR,4S,7R,7aS)-rel-(56-25-7)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS06,GHS07
Signal word  Danger
Hazard statements  H300-H315-H319-H335
Precautionary statements  P305+P351+P338-P264-P270-P280-P301+P310+P330-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P405-P501-P261-P280a-P301+P310a-P501a
Hazard Codes  T+,T
Risk Statements  28-36/37/38-38-37-36-23/24/25
Safety Statements  53-45-36/37/39
RIDADR  UN 2811 6.1/PG 1
WGK Germany  3
RTECS  RN8575000
TSCA  Yes
HazardClass  6.1(a)
PackingGroup  I
HS Code  29329990

Cantharidin price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C7632 Cantharidin 56-25-7 25mg $68 2018-11-20 Buy
Sigma-Aldrich C7632 Cantharidin 56-25-7 100mg $200 2018-11-20 Buy
TCI Chemical C0019 Cantharidin >98.0%(GC) 56-25-7 25mg $53 2018-11-22 Buy
TCI Chemical C0019 Cantharidin >98.0%(GC) 56-25-7 100mg $144 2018-11-22 Buy
Alfa Aesar J61801 Cantharidin, 98% 56-25-7 100mg $183 2018-11-13 Buy

Cantharidin Chemical Properties,Uses,Production

Description

Cantharidin is a natural toxicant of blister beetles. Cantharidin has been used as a medicinal agent for over 2000 years and is listed as a drug under the name of Mylabris in the medical monograph Materia Medica published in 77 AD. Some of the most ancient Chinese prescriptions (306–168 BC) refer to the use of Mylabris for the treatment of furuncles and piles.
Cantharidin can be used for topically (0.7%) treatment of warts, in which the skin under the wart blisters, thereby, lifting the wart off the skin. It is used to treat molluscum contagiosum. Cantharidin is a strong inhibitor of protein phosphatases types 1 (PP1) and 2A (PP2A), which are potentially novel targets for anticancer therapies. Thus, cantharidin is exploited as anticancer drugs. Cantharidin is shown to be cytotoxic to cancer cells and stimulatory on the bone marrow. The renal toxicity of this drug has prevented its use in mainstream oncology.

References

[1] Richard E. Honkanen (1993) Cantharidin, another natural toxin that inhibits the activity of serin/threonine protein phosphatases types 1 and 2A, 330, 283-286
[2] Jennette A. Sakoff, Stephen P. Ackland, Monique L. Baldwin, Mirella A. Keane, Adam
McCluskey (2002) Anticancer activity and protein phosphatase 1 and 2A inhibition of a new generation of cantharidin analogues, 20, 1-11
[3] Erin F. D. Mathes, Ilona J. Frieden (2010) Treatment of molluscum contagiosum with cantharidin: a practical approach, 39, 124-130

Chemical Properties

white to light yellow crystal powde

Chemical Properties

Cantharidin is a brown to black powder.

Uses

In veterinary medicine as a vesicant, rubefa- cient, and counterirritant.

Uses

Cantharidin is a natural toxin produced by blister beetles that moderately inhibits protein phosphatases 1 (PP1) (IC50 = 1.7 μM) and PP2A (IC50 = 0.2 μM) and only weakly inhibits the activity of PP2B (IC50 = 1 mM). It has been shown to stimulate cell cycle progression and induce premature mitosis, used topically (0.7%) as an anti-wart treatment, and has been shown to be active in cervical, tongue, neuroblastoma, bone, leukemia, ovarian, colon, and various other cancer cell lines.

Definition

ChEBI: A monoterpenoid with an epoxy-bridged cyclic dicarboxylic anhydride structure secreted by many species of blister beetle, and most notably by the Spanish fly, Lytta vesicatoria. Natural toxin inhibitor of protein phosphatases 1 and 2A.

General Description

Brown to black powder or plates or scales. Formerly used as a counterirritant and vesicant. Used for the removal of warts. Used as an experimental anti tumor agent. Active ingredient in spanish fly, a reputed aphrodisiac.

Reactivity Profile

Organic anhydrides, such as Cantharidin, are incompatible with acids, strong oxidizing agents, alcohols, amines, and bases.

Hazard

Extremely toxic; questionable carcinogen; powerful irritant to all cells and tissues; deadly poi- son; respiratory failure; death.

Health Hazard

Cantharidin is classified as super toxic. Probable oral lethal dose in humans is less than 5 mg/kg or a taste of less than 7 drops for a 70 kg (150 lb.) person. It is very toxic by absorption through skin.

Fire Hazard

When heated to decomposition Cantharidin emits acrid smoke and irritating fumes.

Biological Activity

Natural toxin inhibitor of protein phosphatases 1 and 2A (K i values are 1.1 and 0.19 μ M respectively); similar to okadaic acid (9,10-Deepithio-9,10-didehydroacanthifolicin ). Displays > 500-fold selectivity over PP2B.

Potential Exposure

Formerly used as a counterirritant and vesicant. Also used for the removal of benign epithelial growths, e.g., warts. Used as an experimental antitumor agent. The active ingredient in “Spanish fly,” a reputed aphrodisia

Shipping

Cantharidin is not specifically listed in the DOT Performance-Oriented Packaging Standards with respect to labeling requirements or restrictions on shipping quantities.

Waste Disposal

It is inappropriate and possibly dangerous to the environment to dispose of expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged, and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.

Cantharidin Preparation Products And Raw materials

Raw materials

Preparation Products


Cantharidin Suppliers

Global( 184)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sale@mainchem.com CHINA 32447 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24191 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30001 58
Chengdu Biopurify Phytochemicals Ltd.
18080483897
maggie@biopurify.com CHINA 2368 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23980 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 sales@jushengtech.com CHINA 28236 58
Shaanxi Pioneer Biotech Co., Ltd .
86-13259417953(Whatsapp)
029-84385017 sales@pioneerbiotech.com CHINA 3029 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 sales@guangaobio.com CHINA 23049 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 35440 58
Shanghai Standard Technology Co., Ltd.
18502101150
+86-21-57127007-6606 ft-sales@nature-standard.com CHINA 422 58

View Lastest Price from Cantharidin manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-09-29 Cantharidin
56-25-7
US $0.00 / mg 5mg ≥98%(HPLC) 10 g Shanghai Standard Technology Co., Ltd.
2019-09-29 Cantharidin
56-25-7
US $0.00 / mg 5mg Analytical Standard 10 g Shanghai Standard Technology Co., Ltd.
2018-07-31 Cantharidin
56-25-7
US $85.00 / KG 1KG 99% customise career henan chemical co

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