ZENIPLATIN
- CAS No.
- 111490-36-9
- Chemical Name:
- ZENIPLATIN
- Synonyms
- ZENIPLATIN;Zeniplatinum;ZENIPLATIN USP/EP/BP;(sp-4-2)-[2,2-Bis(aminc~nethyl)-1,3-propanediol-N,N,][1,1-cyclobutanedicarboxylato(2-)-O,O’]platinum
- CBNumber:
- CB2267690
- Molecular Formula:
- C11H20N2O6Pt
- Molecular Weight:
- 471.36
- MDL Number:
- MFCD00866466
- MOL File:
- 111490-36-9.mol
Melting point | 210-212 °C |
---|---|
FDA UNII | 40ZQ0A17IT |
ZENIPLATIN Chemical Properties,Uses,Production
Originator
Zeniplatin,American Cyanamid (AHP)
Uses
Antineoplastic.
Manufacturing Process
The compound of 2,2-dibromomethyl-1,3-propanediol was prepared by the
method M. Saivier (et al.), Can. J. Chem; 44, 1599 (1966).
A mixture of 13.1 g of 2,2-dibromomethyl-1,3-propanediol, 6.5 g of sodium
azide and 750 ml of dimethylformamide was stirred and heated at 110°-
120°C for 20 h, then clarified and the filtrate evaporated. The residue was
extracted three times with dichloromethane. The extracts were combined and
evaporated, giving 13.65 g of 2,2-bis(azidomethyl)-1,3-propanediol,
compound with dimethylformamide.
A 13.0 g portion of the 2,2-bis(azidomethyl)-1,3-propanediol was reduced
with 0.1 g of platinum dioxide in ethanol, using 50 lb of hydrogen pressure for
20 h. The mixture was then filtered and the filtrate concentrated to dryness,
giving 9.34 g of 2,2-bis(aminomethyl)-1,3-propanediol as a pale yellow oil.
A mixture of 1.34 g of 2,2-bis(aminomethyl)-1,3-propanediol, 4.15 g of
potassium dichloroplatinate and 22 ml of water was stirred for 2 h, then
cooled, the solid collected and washed three times with cold water. This solid
was recrystallized from 60 ml of hot water, giving 890.0 mg of the desired
[2,2-bis(aminomethyl)-1,3-propanediol-N,N']dichloroplatinum as beige
crystals, melting point 223°-225°C (dec.).
A mixture of 0.8 g of [2,2-bis(aminomethyl)-1,3-propanediol-
N,N']dichloroplatinum and 0.78 g of the disilver salt of 1,1-cyclobutane
dicarboxylic acid in 50 ml of water was stirred in the dark overnight and then
filtered. The filtrate was evaporated to dryness, giving 0.72 g of the desired
[2,2-bis(aminomethyl)-1,3-propanediol-N,N'][[1,1'-
cyclobutanedicarboxylato](2-)-O1,O1]platinum as a beige powder, melting
point 202°-205°C (dec.).
Therapeutic Function
Antineoplastic
ZENIPLATIN Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
ZENIPLATIN Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 23899 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2127 | 70 |
Changzhou Bojia Biomedical Technology Co., Ltd. | 2122619822 | czbjpharma@126.com | China | 18488 | 58 |
Shanghai Easy CDMO Co.,Ltd | 021-61734564 | August@easycdmo.com | China | 10010 | 58 |
Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11976 | 58 |
TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 16377 | 58 |
View Lastest Price from ZENIPLATIN manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2021-07-03 | ZENIPLATIN USP/EP/BP
111490-36-9
|
US $1.10 / g | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited |
- ZENIPLATIN USP/EP/BP
111490-36-9
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited