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XEN445

XEN445 Structure
XEN445 structure
CAS No.
1515856-92-4
Chemical Name:
XEN445
Synonyms
XEN445;CS-1251;XEN 445, >=98%;XEN 445; XEN-445;XEN445 >=98% (HPLC);Inhibitor,inhibit,XEN445;(S)-2-(3-(pyridin-2-ylmethoxy)pyrrolidin-1-yl)-5-(trifluoromethyl)benzoic acid;2-[(3S)-3-(2-Pyridinylmethoxy)-1-pyrrolidinyl]-5-(trifluoromethyl)benzoic acid;2-[(3S)-3-(pyridin-2-ylmethoxy)pyrrolidin-1-yl]-5-(trifluoromethyl)benzoic acid;Benzoic acid, 2-[(3S)-3-(2-pyridinylmethoxy)-1-pyrrolidinyl]-5-(trifluoromethyl)-
CBNumber:
CB22715681
Molecular Formula:
C18H17F3N2O3
Molecular Weight:
366.33
MDL Number:
MFCD28166367
MOL File:
1515856-92-4.mol
Last updated:2023-05-18 11:30:58
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XEN445 Properties

Boiling point 490.9±45.0 °C(Predicted)
Density 1.40±0.1 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 25 mg/ml; Ethanol: 14 mg/ml
form A crystalline solid
pka 3.35±0.36(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

XEN445 price More Price(27)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML1324 XEN445 ≥98% (HPLC) 1515856-92-4 5mg $94.3 2024-03-01 Buy
Sigma-Aldrich SML1324 XEN445 ≥98% (HPLC) 1515856-92-4 25mg $462 2024-03-01 Buy
Cayman Chemical 19144 XEN445 ≥98% 1515856-92-4 1mg $32 2024-03-01 Buy
Cayman Chemical 19144 XEN445 ≥98% 1515856-92-4 5mg $97 2024-03-01 Buy
Cayman Chemical 19144 XEN445 ≥98% 1515856-92-4 10mg $184 2024-03-01 Buy
Product number Packaging Price Buy
SML1324 5mg $94.3 Buy
SML1324 25mg $462 Buy
19144 1mg $32 Buy
19144 5mg $97 Buy
19144 10mg $184 Buy

XEN445 Chemical Properties,Uses,Production

Description

Endothelial lipase, a member of the triglyceride lipase gene family expressed in endothelial cells, prefers phospholipid-enriched high-density lipoprotein (HDL) over triglyceride as a substrate. XEN445 is an endothelial lipase inhibitor (IC50 = 237 nM) that demonstrates selectivity for endothelial lipase compared to lipoprotein and hepatic lipases (IC50s = 20 and 9.5 μM, respectivley). An oral dose of 30 mg/kg XEN445 is reported to increase HDL cholesterol concentrations by 16% after three days and by 30% after nine days dosing in wild-type mice.

Uses

XEN445 is a potent and selective endothelial lipase inhibitor.

XEN445 Preparation Products And Raw materials

Raw materials

Preparation Products

XEN445 Suppliers

Global( 82)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
career henan chemical co 		+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		+86-021-61551413 +8618813727289 contact@trustwe.com China 5738 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11681 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 57511 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131981 58
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2923 55
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		58
TargetMol Chemicals Inc. 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		58
Aladdin Scientific 		58
Amadis Chemical Company Limited 		58
Shanghai Boyle Chemical Co., Ltd. 55

View Lastest Price from XEN445 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-[(3S)-3-(2-Pyridinylmethoxy)-1-pyrrolidinyl]-5-(trifluoromethyl)benzoic acid pictures 2019-12-24 2-[(3S)-3-(2-Pyridinylmethoxy)-1-pyrrolidinyl]-5-(trifluoromethyl)benzoic acid
1515856-92-4
 US $1.00 / KG 1KG Min98% HPLC g/kg/ton Career Henan Chemical Co

XEN445 Spectrum

XEN445(1515856-92-4)MS

1515856-92-4(XEN445)Related Search:

XE 991 dihydrochloride (S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-triMethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate ADX-47273 (S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one
XEN 445, >=98% XEN445 2-[(3S)-3-(2-Pyridinylmethoxy)-1-pyrrolidinyl]-5-(trifluoromethyl)benzoic acid (S)-2-(3-(pyridin-2-ylmethoxy)pyrrolidin-1-yl)-5-(trifluoromethyl)benzoic acid 2-[(3S)-3-(2-Pyridinylmethoxy)-1-pyrrolidinyl]-5-(trifluoromethyl)benzoic acid XEN445 XEN445 (S)-2-(3-(PYRIDIN-2-YLMETHOXY)PYRROLIDIN-1-YL)-5-(TRIFLUOROMETHYL)BENZOIC ACID. HCL 2-[(3S)-3-(2-Pyridinylmethoxy)-1-pyrrolidinyl]-5-(trifluoromethyl)benzoic acid 2-[(3S)-3-(pyridin-2-ylmethoxy)pyrrolidin-1-yl]-5-(trifluoromethyl)benzoic acid CS-1251 XEN 445; XEN-445 Benzoic acid, 2-[(3S)-3-(2-pyridinylmethoxy)-1-pyrrolidinyl]-5-(trifluoromethyl)- XEN445 >=98% (HPLC) Inhibitor,inhibit,XEN445 1515856-92-4 Inhibitors