2'-O-Methylguanosine
- CAS No.
- 2140-71-8
- Chemical Name:
- 2'-O-Methylguanosine
- Synonyms
- 2'-OMe-G;2'-OMe-G;2'-OMe-Gr;2'-OMe-rG;2'-OMe-Gr;2'-OMe Guanosine;2'-OMe Guanosine;2'-O-METHYLGUANOSINE;2'-O-Methylguanosine;2 '- Methoxyguanosine
- CBNumber:
- CB2276641
- Molecular Formula:
- C11H15N5O5
- Molecular Weight:
- 297.27
- MDL Number:
- MFCD00057053
- MOL File:
- 2140-71-8.mol
- MSDS File:
- SDS
Melting point | 227-231°C (dec.) |
---|---|
Density | 1.98±0.1 g/cm3(Predicted) |
storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
solubility | Aqueous Base (Slightly), DMSO (Slightly), |
pka | 9?+-.0.20(Predicted) |
form | Powder |
color | White to Off-white |
λmax | 256 (pH 1);258 (pH 11) |
InChI | InChI=1S/C11H15N5O5/c1-20-7-6(18)4(2-17)21-10(7)16-3-13-5-8(16)14-11(12)15-9(5)19/h3-4,6-7,10,17-18H,2H2,1H3,(H3,12,14,15,19)/t4-,6-,7-,10-/m1/s1 |
InChIKey | OVYNGSFVYRPRCG-KQYNXXCUSA-N |
SMILES | OC[C@H]1O[C@@H](N2C3=C(C(NC(=N3)N)=O)N=C2)[C@H](OC)[C@@H]1O |
CAS DataBase Reference | 2140-71-8(CAS DataBase Reference) |
FDA UNII | W722H4PA1S |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302-H315-H319-H335 | |||||||||
Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36/37/38-22 | |||||||||
Safety Statements | 26-36-60-36/37 | |||||||||
HS Code | 29349990 | |||||||||
NFPA 704 |
|
2'-O-Methylguanosine price More Price(26)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TCI Chemical | M2318 | 2'-O-Methylguanosine Hydrate >98.0%(HPLC)(T) | 2140-71-8 | 1g | $280 | 2024-03-01 | Buy |
TCI Chemical | M2318 | 2'-O-Methylguanosine Hydrate >98.0%(HPLC)(T) | 2140-71-8 | 200mg | $89 | 2024-03-01 | Buy |
Alfa Aesar | J65770 | 2'-O-Methylguanosine, 99% | 2140-71-8 | 1g | $82.4 | 2024-03-01 | Buy |
Alfa Aesar | J65770 | 2'-O-Methylguanosine 99% | 2140-71-8 | 250mg | $20.2 | 2021-12-16 | Buy |
Cayman Chemical | 21039 | 2'-O-Methylguanosine ≥98% | 2140-71-8 | 250mg | $57 | 2024-03-01 | Buy |
2'-O-Methylguanosine Chemical Properties,Uses,Production
Description
2''-O-Methylguanosine is a modified nucleoside that is produced in tRNAs by the action of tRNA guanosine-2’-O-methyltransferase, using S-adenosyl-L-methionine (Item Nos. 16376 | 13956) as a substrate. Through its interaction with other modified nucleosides, 2''-O-methylguanosine is thought to stabilize the structure of the tRNA. 2''-O-Methylguanosine can also be found in rRNA. Normal and modified nucleosides, including 2''-O-methylguanosine, have been shown to be secreted by a natural suppressor cell line and induce apoptosis in K562/Molt4 target cells.
Chemical Properties
White Solid
Uses
Guanosine analog. Used for preparation of nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase.
Definition
ChEBI: Guanosine with the hydrogen on the hydroxyl at position C-2' substituted with a methyl group.
Synthesis
8-Thio-2'-O-methylguanosine (1 mmole) is dissolved in water and the solution is heated at reflux with Raney nickel for 6 h. The product is isolated by passing the solution through a short pad of celite and is further crystallizing to afford 2'-O-methylguanosine.
2'-O-Methylguanosine Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Wuhu Nuowei chemistry Co., Ltd. | +86-0553-2911116-802 +undefined17756524438 | sales1@nuowei-chem.com | China | 1640 | 58 |
Yunbio Tech Co.,Ltd. | +86-010-60605551 +86-18046518538 | yunbiochem@126.com | China | 321 | 58 |
Zhengzhou Chemprize Biotech Co., Ltd. | +86-86-0371-56768238 +8615981919713 | sales@chemprize.com | China | 297 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21667 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 7621 | 58 |
Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 19536 | 58 |
Nanjing Baifuli Technology Co., Ltd. | +86-15335185688 | sales@unisyn.cn | CHINA | 332 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
View Lastest Price from 2'-O-Methylguanosine manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-08-08 | 2'-O-Methylguanosine
2140-71-8
|
US $0.00 / g | 1g | 98% | 100kg | Hefei Huana Biomedical Technology Co.,Ltd. | ||
2024-08-07 | 2'-O-Methylguanosine
2140-71-8
|
US $0.00 / KG | 1KG | 98% | 300KG per month | Yunbio Tech Co.,Ltd. | ||
2023-04-04 | 2'-O-Methylguanosine
2140-71-8
|
US $0.00-0.00 / kg | 1kg | 98% | 500kg per month | Zhejiang Hengkang Pharmaceutical Co., Ltd. |
- 2'-O-Methylguanosine
2140-71-8
- US $0.00 / g
- 98%
- Hefei Huana Biomedical Technology Co.,Ltd.
- 2'-O-Methylguanosine
2140-71-8
- US $0.00 / KG
- 98%
- Yunbio Tech Co.,Ltd.
- 2'-O-Methylguanosine
2140-71-8
- US $0.00-0.00 / kg
- 98%
- Zhejiang Hengkang Pharmaceutical Co., Ltd.
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