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RESCINNAMINE

RESCINNAMINE
RESCINNAMINE structure
CAS No.
24815-24-5
Chemical Name:
RESCINNAMINE
Synonyms
Rozex;Apolon;Rescin;Tuareg;ANAPREL;Anapral;Cartric;Moderil;Resipal;Apoterin
CBNumber:
CB2344278
Molecular Formula:
C35H42N2O9
Formula Weight:
634.73
MOL File:
24815-24-5.mol

RESCINNAMINE Properties

Melting point:
238-239°C
alpha 
D24 -97° (c = 1 in chloroform)
Boiling point:
669.26°C (rough estimate)
Density 
1.2161 (rough estimate)
refractive index 
1.5300 (estimate)
storage temp. 
2-8°C
pka
pKa 6.4 (Uncertain)
Stability:
Stable, but darkens slowly in light. Incompatible with strong oxidizing agents.
CAS DataBase Reference
24815-24-5
FDA UNII
Q6W1F7DJ2D
ATC code
C02AA01
EPA Substance Registry System
Rescinnamine (24815-24-5)
SAFETY
  • Risk and Safety Statements
Hazard Codes  Xn
Risk Statements  25-20/21/22
Safety Statements  22-45-36
RIDADR  1544
HazardClass  6.1(b)
PackingGroup  III

RESCINNAMINE Chemical Properties,Uses,Production

Description

This Rauwolfia alkaloid is found in the barks of R. serpentina and R. vomitora and was originally given the name Reserpinine, this being altered to avoid confusion with another alkaloid of the same name (q.v.). The base has [α]17D - 99.2° (c 1.3, CHCI3). From chemical degradation and spectroscopic analysis, the structure has been established as the 3:4: 5-trimethoxycinnamoyl ester of reserpic acid.

Chemical Properties

white to cream powder

Uses

Rescinnamine occurs in the roots of a num ber of Rauwolfia species. Therapeutically, itis used as an antihypertensive agent.

brand name

Moderil (Pfizer).

General Description

Odorless white to cream colored crystalline powder.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

The neat material darkens slowly on exposure to light. In solution this occurs more rapidly. .

Health Hazard

The pharmacological properties of rescinnamine are similar to those of reserpine, butthe side effects are low. It acts as a sedativeand hypotensive. A dose of 0.25 mg/day mayproduce the effect of sleepiness in humans.Excessive doses may produce depression,nightmare, nausea, diarrhea, and hypotension.
LD50 value, oral (rats): 1000 mg/kg
The carcinogenicity of rescinnamine inanimals or humans is unknown.

Fire Hazard

Flash point data for RESCINNAMINE are not available. RESCINNAMINE is probably combustible.

Purification Methods

Crystallise it from *benzene, MeOH or aqueous Me2CO. The hydrochloride has m 232o(dec) (from MeOH) and [] D -74o (MeOH). It is an antihypertensive. [Klohs et al. J Am Chem Soc 77 2241 1955, Beilstein 25 III/IV 1323.]

References

Haack e tal., Naturwiss., 41, 214 (1954)
Klohs, Draper, Keller.,J. Amer. Chem. Soc., 77,2241 (1955)
Kidd., Chem. & Ind., 1481 (1955)
Popelak, Lettenbauer., Arch. Pharm., 296,261 (1963)

RESCINNAMINE Preparation Products And Raw materials

Raw materials

Preparation Products


RESCINNAMINE Suppliers

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RESCINNAMINE Spectrum


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