PROGUANIL HYDROCHLORIDE
- CAS No.
- 537-21-3
- Chemical Name:
- PROGUANIL HYDROCHLORIDE
- Synonyms
- M-5943;chlorproguanil;Chloroproguanil;PROGUANIL HYDROCHLORIDE;1-(3,4-Dichlorophenyl)-5-isopropylbiguanide;N1-3,4-Dichlorophenyl-N5-isopropyldiguanide;N-(3,4-Dichlorophenyl)-N'-isopropyldicarbonimido/ic diamide/imido;N-(3,4-Dichlorophenyl)-N'-(1-Methylethyl)iMidodicarboniMidic DiaMide;(1E)-1-[amino-(3,4-dichloroanilino)methylidene]-2-propan-2-ylguanidine;Imidodicarbonimidic diamide, N-(3,4-dichlorophenyl)-N'-(1-methylethyl)-
- CBNumber:
- CB2488954
- Molecular Formula:
- C11H15Cl2N5
- Molecular Weight:
- 288.18
- MDL Number:
- MFCD01732193
- MOL File:
- 537-21-3.mol
| Melting point | 120-121 °C |
|---|---|
| Boiling point | 350.7±52.0 °C(Predicted) |
| Density | 1.40±0.1 g/cm3(Predicted) |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 10.77±0.10(Predicted) |
| color | White to Off-White |
| BCS Class | 1 |
| Stability | Hygroscopic |
| FDA UNII | 8O3249M729 |
PROGUANIL HYDROCHLORIDE price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | API0009147 | CHLORPROGUANIL 95.00% | 537-21-3 | 50MG | $750.75 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0009147 | CHLORPROGUANIL 95.00% | 537-21-3 | 500MG | $1963.5 | 2021-12-16 | Buy |
PROGUANIL HYDROCHLORIDE Chemical Properties,Uses,Production
Uses
PROGUANIL HYDROCHLORIDE is an antimalarial agent used in combination with Dapsone (D193250).
Definition
ChEBI: Chlorproguanil is a dichlorobenzene.
Clinical Use
Malaria chemoprophylaxis
Drug interactions
Potentially hazardous interactions with other drugs
Anticoagulants: effect of warfarin possibly enhanced.
Antimalarials: avoid concomitant use with
artemether/lumefantrine; increased antifolate effect
with pyrimethamine.
Metabolism
Proguanil is metabolised in the liver to the active metabolite, cycloguanil, and to p-chlorophenylbiguanide which is inactive, mainly by cytochrome P450, CYP 2C19 and slightly by CYP 3A4. Unlike proguanil and p-chlorophenylbiguanide, cycloguanil is not concentrated in erythrocytes so concentrations of cycloguanil in plasma and whole blood are similar. About 40-60% of a dose of proguanil is excreted in the urine, 60% of this as the unchanged drug, 30% as cycloguanil, and 8% as p-chlorophenylbiguanide. About 10% of a dose is excreted in the faeces.
PROGUANIL HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | 1026@dideu.com | China | 9116 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15421 | 60 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55717 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | 029-81124267 15229202216 | 1073@dideu.com | China | 10011 | 58 |
| Hebei Zhenjia new material Co., LTD | 0319-5925599 13315915972 | 13313090628@163.com | China | 3489 | 58 |
| Shanghai Haohong Pharmaceutical Co., Ltd. | 400-8210725 4008210725 | malulu@leyan.com | China | 40036 | 58 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | SY06@accelachem.com | China | 10334 | 58 |
| Hebei Zhentian food additives Co., LTD | 0319-5925599 13373390591 | 13373390591@163.com | China | 11442 | 58 |