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APROBARBITAL METHANOL SOLUTION

APROBARBITAL METHANOL SOLUTION Structure
APROBARBITAL METHANOL SOLUTION structure
CAS No.
77-02-1
Chemical Name:
APROBARBITAL METHANOL SOLUTION
Synonyms
Numal;Isonal;Aprozal;Allonal;Alurate;Allional;NSC120769;Aprobarbita;Allypropymal;Aprobarbitone
CBNumber:
CB2497884
Molecular Formula:
C10H14N2O3
Molecular Weight:
210.23
MDL Number:
MOL File:
77-02-1.mol
Last updated:2023-05-15 10:44:01

APROBARBITAL METHANOL SOLUTION Properties

Melting point 140-141.5°
Boiling point 349.75°C (rough estimate)
Density 1.2056 (rough estimate)
refractive index 1.5000 (estimate)
storage temp. 2-8°C
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka 7.81±0.10(Predicted)
color White to Off-White
Water Solubility 4.121g/L(25 ºC)
FDA UNII Q0YKG9L6RF

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P264-P270-P301+P310-P321-P330-P405-P501
Hazard Codes  F,T
Risk Statements  11-23/25-36/38
Safety Statements  16-24-45
Toxicity LD50 i.p. in mice: 200 mg/kg (Frey)
DEA Controlled Substances CSCN: 2100
CSA SCH: Schedule III
NARC: No

APROBARBITAL METHANOL SOLUTION Chemical Properties,Uses,Production

Originator

Alurate,Roche

Uses

Controlled substance (depressant). Sedative, hypnotic.

Definition

ChEBI: A member of the class of barbiturates that is pyrimidine-2,4,6(1H,3H,5H)-trione substituted by an isopropyl and a prop-1-en-3-yl group at position 5.

Manufacturing Process

170 parts of isopropylbarbituric acid are mixed with 500 parts of water and dissolved by adding 135 parts of a 30 percent of the solution of sodium hydroxide. To this solution are added 130 parts of 130 parts of allylbromide. An emulsion obtained is stirred at an inner temperature of about 25°C. The reaction is at first accompanied by a slight development of heat. After 12 hours the reaction is brought to a close. When cooled down the isopropylallylbarbituric acid is drawn off. The yield is more than 80 percent of the theoretically calculated quantity. By crystallization from diluted alcohol the pure isopropylallylbarbituric acid is obtained in colorless crystals of the melting point 137-138°C.

Therapeutic Function

Sedative, Hypnotic

World Health Organization (WHO)

Aprobarbital is an intermediate-acting barbiturate. See WHO comment for barbiturates.

APROBARBITAL METHANOL SOLUTION Preparation Products And Raw materials

Raw materials

Sodium hydroxide Allyl bromide 5-ISOPROPYLBARBITURIC ACID

Preparation Products

77-02-1(APROBARBITAL METHANOL SOLUTION)Related Search:

5-(2-bromoallyl)-5-(1-methylpropyl)-1H,3H,5H-pyrimidine-2,4,6-trione methohexital sodium SECOBARBITAL 5-ISOPROPYLBARBITURIC ACID Narcobarbital
Methohexital APROBARBITAL METHANOL SOLUTION BARBITAL Barbituric acid Probarbital
SECOBARBITAL-D5 (1-METHYL-D3, BUTYL-2,2-D2) (R)-(+)-Seconal S(-)-Secobarbital sodium 5-allyl-5-isopropylbarbiturate R(+)-Secobarbital sodium
S(-)-Secobarbital sodium TALBUTAL CIII (250 MG) CYCLOPENTOBARBITAL

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Allopropylbarbital alurateelixirverdum Aprobarbita Aprobarbitone Aprozal Isonal isonal(swedish) Isopropylallylbarbituric acid isopropylallylbarbituricacid Numal Propallylonal M (des-Br) APROBARBITAL METHANOL SOLUTION 5-Ally-5-isopropyl barbituric acid allyisopropyl-barbituric acid Aprobarbital (base and/or unspecified salts) Aprobarbital CIII (200 mg) (AS) DISCONTINUED 5-(1-Methylethyl)-5-(2-propen-1-yl)-2,4,6(1H,3H,5H)-pyriMidinetrione NSC120769 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-(1-methylethyl)-5-(2-propenyl)- 6(1h,3h,5h)-pyrimidinetrione,5-(1-methylethyl)-5-(2-propenyl)-4 Allional Allonal Allylisopropylbarbituric acid allylisopropylbarbituricacid Allylisopropylmalonylurea Allylpropymal Allypropymal Alurate Alurate Elixir Verdum 5-(1-methylethyl)-5-(2-propenyl)-2,4,6(1h,3h,5h)-pyrimidinetrione 5-Allyl-5-isopropyl-2,4,6(1H,3H,5H)-pyrimidinetrione 5-Allyl-5-isopropylbarbiturate 5-Allyl-5-isopropylbarbituric acid 5-allyl-5-isopropyl-barbituricaci 5-allyl-5-isopropylbarbituricacid 5-Isopropyl-5-allylbarbituric acid 5-isopropyl-5-allylbarbituricacid 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-(1-methylethyl)-5-(2-propen-1-yl)- Aprobarbital Solution, 100ppm 77-02-1 C3H5C3H7C4H2N2O3 Heterocycles Intermediates & Fine Chemicals Pharmaceuticals