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Paraldehyde structure
Chemical Name:
Pcho;Paral;ALDEHYDE;NSC 9799;FEMA 2003;ALDEFRESH;Elaldehyde;Paraldehyd;Paraldeide;paradehyde
Molecular Formula:
Formula Weight:
MOL File:

Paraldehyde Properties

Melting point:
12 °C
Boiling point:
65-82 °C
0.994 g/mL at 20 °C(lit.)
vapor density 
1.52 (vs air)
vapor pressure 
25.89 psi ( 55 °C)
refractive index 
n20/D 1.39
Flash point:
30 °F
storage temp. 
16(at 25℃)
Specific Gravity
explosive limit
Water Solubility 
125 g/L (25 ºC)
Stable. Flammable. Incompatible with strong oxidizing agents, mineral acids.
CAS DataBase Reference
123-63-7(CAS DataBase Reference)
NIST Chemistry Reference
EPA Substance Registry System
1,3,5-Trioxane, 2,4,6-trimethyl-(123-63-7)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
  • NFPA
Hazard Codes  F
Risk Statements  11-R11-10
Safety Statements  9-16-29-33-S9-S33-S29-S16
RIDADR  UN 1993 3/PG 2
WGK Germany  1
RTECS  YK0525000
Autoignition Temperature 235 °C
HazardClass  3.2
PackingGroup  III
HS Code  29125000
Hazardous Substances Data 123-63-7(Hazardous Substances Data)
Toxicity LD50 orally in rats: 1.65 g/kg (Figot)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H226 Flammable liquid and vapour Flammable liquids Category 3 Warning
Precautionary statements:

NFPA 704

Diamond Hazard Value Description
2 1
Health   2 Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury (e.g. diethyl ether, ammonium phosphate, iodine)
Flammability   3 Liquids and solids (including finely divided suspended solids) that can be ignited under almost all ambient temperature conditions . Liquids having a flash point below 22.8 °C (73 °F) and having a boiling point at or above 37.8 °C (100 °F) or having a flash point between 22.8 and 37.8 °C (73 and 100 °F). (e.g. gasoline, acetone)
Instability   1 Normally stable, but can become unstable at elevated temperatures and pressures (e.g. propene)

(NFPA, 2010)

Paraldehyde price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.18255 Paraldehyde for synthesis. CAS 123-63-7, molar mass 132.15 g/mol., for synthesis 123-63-7 8182550100 $29 2018-11-23 Buy
Sigma-Aldrich P5520 Paraldehyde ≥97% 123-63-7 100ml $82.6 2018-11-20 Buy
Sigma-Aldrich 8.18255 Paraldehyde for synthesis. CAS 123-63-7, molar mass 132.15 g/mol., for synthesis 123-63-7 8182551000 $56.5 2018-11-23 Buy

Paraldehyde Chemical Properties,Uses,Production

Chemical Properties

Colourless to yellowish clear liquid

Chemical Properties

Paraldehyde is a colorless liquid. Pleasant, sweet odor.


Paraldehyde is used as solvent for fats, oils, waxes, rubber and resins; as substitute for acetaldehyde; as intermediate for organic chemicals, dyestuffs, accelerators for vulcanizations, rubber oxidants, etc. Product Data Sheet


Reactant involved in:• ;Modified Sanford reaction1• ;Synthesis of N-arylbenzoquinaldinium derivatives with antimicrobial activity2• ;Hydroformylation of alkenylamines3• ;Studies of molecules with inhibitory activity against HIV-1 integrase4• ;Irregular Wittig reactions for the formation of α-hydroxyketones5


manufacture of organic compounds.


ChEBI: A trioxane that is 1,3,5-trioxane substituted by methyl groups at positions 2, 4 and 6.

brand name

Paral (Forest).

General Description

Paraldehyde, 2,4,6-trimethyl-strioxane,paracetaldehyde, is recognizable as the cyclictrimer of acetaldehyde. It is a liquid with a strong characteristicodor detectable in the expired air and an unpleasanttaste. These properties limit its use almost exclusively toan institutional setting (e.g., in the treatment of deliriumtremens). In the past, when containers were opened and airadmitted and then reclosed and allowed to stand, fatalitiesoccurred because of oxidation of paraldehyde to glacialacetic acid.

General Description

A clear colorless liquid with a pleasant odor. Flash point 96°F. Melting point 54°F. Less dense than water. Vapors are heavier than air.

Air & Water Reactions

Highly flammable. Slightly soluble in water. Decomposed by light and air, on prolonged storage, to acetaldehyde and acetic acid.

Reactivity Profile

Paraldehyde is an aldehyde. Paraldehyde is decomposed by light and air, on prolonged storage, to acetaldehyde and acetic acid. Incompatible with alkalis, hydrocyanic acid iodides and oxidizers.

Health Hazard

INHALATION AND INGESTION: Irritation, headache, bronchitis, pulmonary edema. Irritating to digestive tract. Hypnotic and analgesic properties. Incoordination and drowsiness, followed by sleep. Larger doses-coma-weak pulse and shallow respiration, cyanosis-death from respiratory paralysis. EYES: irritation-can cause serious injury. SKIN: Dermatitis (skin inflammation).

Safety Profile

A human poison by rectal route. Moderately toxic to humans by intramuscular route. Moderately toxic experimentally by inhalation, ingestion, intraperitoneal, and subcutaneous routes. Human systemic effects by rectal route: necrotic changes. A skin and severe eye irritant. Low doses produce hypnotic and analgesic effects. Larger doses depress the nervous system with loss of reflexes, coma, and respiratory depression leadmg to respiratory paralysis and death. Chronic effects include weight loss, muscular weakness, and mental fatigue. However, poisoning is rare. A hypnotic agent. Dangerous fire hazard when exposed to heat, flame, or oxidzers. Slight explosion hazard when exposed to heat or flame. Dangerous; keep away from heat and open flame. To fight fire, use alcohol foam, CO2, dry chemical. Potentially violent reaction with nitric acid. Incompatible with alkahes, hydrocyanic acid, iodides, oxidzers. When heated to decomposition it emits acrid smoke and irritating fumes. See also ALDEHYDES

Potential Exposure

Paraldehyde is used primarily in medicine. It is used as a hypnotic agent, in delirium tremens; and in treatment of psychiatric states characterized by excitement when drugs must be given over a long period of time. It also is administered for intractable pain which does not respond to opiates and for basal and obstetrical anesthesia. It is effective against experimentally induced convulsions and has been used in emergency therapy of tetanus, eclampsia, status epilepticus; and poisoning by convulsant drugs. Since it is used primarily in medicine, the chance of accidental human exposure or environmental contamination is low. However, paraldehyde decomposes to acetaldehyde and acetic acid; these compounds have been found to be toxic. In this case, occupational exposure or environmental contamination is possible. Since paraldehyde is prepared from acetaldehyde by polymerization in the presence of an acid catalyst, there exists a potential for adverse effects, although none have been reported in the available literature. It is also used in the manufacture of organic compounds.

First aid

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit. Medical observation is recommended for 2448 hours after breathing overexposure, as pulmonary edema may be delayed. As first aid for pulmonary edema, a doctor or authorized paramedic may consider administering a drug or other inhalation therapy.


UN1264 Paraldehyde, Hazard Class: 3; Labels: 3-Flammable liquid.

Purification Methods

Wash paraldehyde with water and fractionally distil it. Alternatively, it is purified by drying with anhydrous Na2SO4, then cooled to 5o, and the frozen material is separated by decantation. The solid is distilled (b 121-124o/atm), the distillate is collected, stored over anhydrous Na2SO4 for several days and re-distilled at atmospheric pressure before use [Le Fevre et al. J Chem Soc 290 1950]. The 2r,4c,6t-trimethyl-1,3,5-trioxane has m 14.5o, b 125o/760mm. [Beilstein 19 II 394, 19 III/IV 4715. 19/9 V 112.]


Vapor or liquid may form explosive mixture with air. Incompatible with strong oxidants, strong acids; alkalis, ammonia, amines, iodides, hydrocyanic acid. Violent reaction with liquid oxygen. Contact with acids form acetaldehyde. Attacks rubber and plastics.

Waste Disposal

Incineration in added solvent. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.

Paraldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

Paraldehyde Suppliers

Global( 196)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37127788 CHINA 495 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32457 55
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114 CHINA 6374 58
Chemwill Asia Co.,Ltd.
86-21-51861608;;; CHINA 24001 58
Jinan Finer Chemical Co., Ltd
+86-531-88989539 CHINA 939 58
career henan chemical co
+86-371-86658258 CHINA 19923 58
Wutong Aroma Chemicals Co., Ltd 0531-88817695
0531-88817695 China 278 68
Shanghai Aladdin Bio-Chem Technology Co.,LTD 021-20337333/400-620-6333
021-50323701 China 24991 65
Shanghai Bojing Chemical Co., Ltd 13681836088
021-37597788 China 468 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933; China 96815 76

View Lastest Price from Paraldehyde manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-09 Paraldehyde
US $1.00 / KG 1KG 98% 100KG career henan chemical co

Paraldehyde Spectrum

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