3-Amino-1-propanesulfonic acid
- CAS No.
- 3687-18-1
- Chemical Name:
- 3-Amino-1-propanesulfonic acid
- Synonyms
- HOMOTAURINE;3-AMINOPROPANE-1-SULFONIC ACID;3 APS;NC 758;TRAMIP;Alzhemed;NSC 77071;Homotaurin;TRAMIPROSATE;3-Sulfopropylamine
- CBNumber:
- CB2741107
- Molecular Formula:
- C3H9NO3S
- Molecular Weight:
- 139.17
- MDL Number:
- MFCD00008225
- MOL File:
- 3687-18-1.mol
- MSDS File:
- SDS
| Melting point | 293 °C (dec.)(lit.) |
|---|---|
| Density | 1.202 (estimate) |
| refractive index | 1.5130 (estimate) |
| storage temp. | 2-8°C |
| solubility | Water (Slightly) |
| pka | 1.06±0.50(Predicted) |
| form | Crystalline Powder |
| color | White to slightly blue |
| LogP | -4.555 |
| CAS DataBase Reference | 3687-18-1(CAS DataBase Reference) |
| FDA UNII | 5K8EAX0G53 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 1 | |||||||||
| HS Code | 29049090 | |||||||||
| NFPA 704 |
|
3-Amino-1-propanesulfonic acid price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A76109 | 3-Amino-1-propanesulfonic acid 97% | 3687-18-1 | 1g | $47.6 | 2024-03-01 | Buy |
| Sigma-Aldrich | PHR2822 | Acamprosate Related Compound A Pharmaceutical Secondary Standard; Certified Reference Material | 3687-18-1 | 50MG | $485 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1000565 | Acamprosate Related Compound A United States Pharmacopeia (USP) Reference Standard | 3687-18-1 | 15mg | $1140 | 2024-03-01 | Buy |
| TCI Chemical | A2602 | 3-Amino-1-propanesulfonic Acid >98.0%(T) | 3687-18-1 | 5g | $127 | 2024-03-01 | Buy |
| TCI Chemical | A2602 | 3-Amino-1-propanesulfonic Acid >98.0%(T) | 3687-18-1 | 25g | $317 | 2024-03-01 | Buy |
3-Amino-1-propanesulfonic acid Chemical Properties,Uses,Production
Description
Homotaurine (also known as tramiprosate (INN), 3-amino-1-propanesulfonic acid, or 3-APS) is a natural sulfonic acid found in seaweed. Tramiprosate is a sulfated glycosaminoglycan mimetic that was reported to bind soluble Aβ and inhibit the interaction of Aβ with endogenous glycosaminoglycans, thereby preventing β-sheet formation. Conversely, tramiprosate was also reported to promote tau polymerization into fibrillar aggregates. It is also an analog of GABA that can act as a partial agonist of GABAA receptors, as well as an antagonist at GABAB receptors.
Chemical Properties
White Powder
Uses
3-Amino-1-propanesulfonic acid is a Important gabamimetic agent-evokes neurological responses similar to those elicited by γ-aminobutyric acid (GABA). It is an intermediate in the synthesis of acamprosate. acamprosate is an alcohol addiction treatment commonly used to reduce urges to drink and help people in recovery remain sober.
Definition
ChEBI: 3-Aminopropanesulfonate is an organosulfonic acid.
Biological Activity
Sulfated glycosaminoglycan (sGAG) mimetic that targets soluble amyloid β (A β ) and maintains A β in a non-fibrillar form. Decreases A β 42-induced neuronal death and inhibits amyloid deposition in vitro . Decreases brain amyloid plaque load by 30%, increases tau polymerization and is brain penetrant. Also a GABA analog that protects against the convulsant and cytotoxic activity of kainic acid in vivo .
3-Amino-1-propanesulfonic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 7845 | 58 |
| airuikechemical co., ltd. | +undefined86-15315557071 | sales02@airuikechemical.com | China | 994 | 58 |
| Ouhuang Engineering Materials (Hubei) Co., Ltd | +8617702722807 | admin@hbouhuang.com | China | 2259 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15928 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | 18957127338 | stella@zetchem.com | China | 2141 | 58 |
View Lastest Price from 3-Amino-1-propanesulfonic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-18 | Tramiprosate
3687-18-1
|
US $1.00 / KG | 1KG | 99.91% | 200000 | Ouhuang Engineering Materials (Hubei) Co., Ltd | |
 |
2024-04-08 | 3-Amino-1-propanesulfonic acid
3687-18-1
|
US $34.00-1.20 / kg | 1kg | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2024-04-08 | 3-amino-1-propanesulfonic acid
3687-18-1
|
US $0.00-0.00 / Kg | 1Kg | 99.9% | 200tons | airuikechemical co., ltd. |
-
- Tramiprosate
3687-18-1
- US $1.00 / KG
- 99.91%
- Ouhuang Engineering Materials (Hubei) Co., Ltd
-
- 3-Amino-1-propanesulfonic acid
3687-18-1
- US $34.00-1.20 / kg
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 3-amino-1-propanesulfonic acid
3687-18-1
- US $0.00-0.00 / Kg
- 99.9%
- airuikechemical co., ltd.