OXPRENOLOL
- CAS No.
- 1189649-47-5
- Chemical Name:
- OXPRENOLOL
- Synonyms
- OXPRENOLOL;Oxprenolol-d7 HCl;[2H7]-Oxprenolol Hydrochloride;2-PROPANOL,1-(2-ALLYLOXYPHENOXY)-3-(ISOPROPYLAMINO)-;1-(1,1,1,2,3,3,3-heptadeuteriopropan-2-ylamino)-3-(2-prop-2-enoxyphenoxy)propan-2-ol;1-(1,1,1,2,3,3,3-heptadeuteriopropan-2-ylamino)-3-(2-prop-2-enoxyphenoxy)propan-2-ol:hydrochloride
- CBNumber:
- CB2843988
- Molecular Formula:
- C15H23NO3
- Molecular Weight:
- 265.34802
- MDL Number:
- MFCD34568051
- MOL File:
- Mol file
- MSDS File:
- SDS
| Melting point | 97-98°C |
|---|---|
| storage temp. | -20°C Freezer, Under Inert Atmosphere |
| solubility | Dichloromethane (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | pKa 9.5 (Uncertain) |
| color | White to Off-White |
| FDA UNII | 519MXN9YZR |
| ATC code | C07AA02 |
OXPRENOLOL Chemical Properties,Uses,Production
Chemical Properties
White Solid
Originator
Trasicor,Ciba Geigy ,Italy,1970
Uses
Oxprenolol is a free base of Oxprenolol Hydrochloride(O870500) which is a β-Adrenergic blocker. Antihypertensive, antianginal, antiarrhythmic.
Manufacturing Process
75 grams of pyrocatechol monoallyl ether, 75 grams of epichlorohydrin, 75 grams of potassium carbonate and 400 ml of acetone are stirred and heated at the boil for 12 hours. The potassium carbonate is then filtered off. The solvent is distilled off in a water-jet vacuum. The residual oil is dissolved in ether and agitated with 2 N sodium hydroxide solution. The ether is separated, dried and distilled off. The residue is distilled in a water-jet vacuum. 3-(ortho-allyloxy-phenoxy)-1,2-epoxypropane passes over at 145° to 157°C under 11 mm Hg pressure. A solution of 15 grams of 3-(ortho-allyloxyphenoxy)-1,2-epoxypropane and 15 grams of isopropylamine in 20 ml of ethanol is refluxed for 4 hours. The excess amine and the alcohol are then distilled off under vacuum, to leave 1-isopropylamino-2-hydroxy-3-(orthoallyloxy-phenoxy)-propane which melts at 75° to 80°C after recrystallization from hexane.
Therapeutic Function
Antiarrhythmic
OXPRENOLOL Preparation Products And Raw materials
OXPRENOLOL Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 | admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com | China | 20000 | 58 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| Artis Biotech Co. Ltd. | 19138486554 18582380095 | sales@artisbio.com | China | 3066 | 58 |
| Jinan ponder chemical co. LTD | 0531-0000 | thinklifescience@163.com | China | 19690 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44894 | 58 |
| Abmole Bioscience Inc. | 021-50967598 02150967598 | sales@abmole.cn | China | 4495 | 58 |
| TCI (Shanghai) Chemical Trading Co., Ltd. | 021-61109150 | sales@tcisct.com | China | 31183 | 58 |
| LGC Science (Shanghai) Ltd. | 17717235263 | cindy.yang@lgcgroup.com | China | 11437 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 17301488900 | judy.xia@synzest.com | China | 13698 | 58 |