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Epichlorohydrin

Description References
Epichlorohydrin
Epichlorohydrin structure
CAS No.
106-89-8
Chemical Name:
Epichlorohydrin
Synonyms
ECH;J006;SKEkhG;(±nci-c07001;Epicloridrina;EPICHLORHYDRIN;Epichlorohydrin;Epichlorhydrine;Epiohiorohydrin
CBNumber:
CB8381781
Molecular Formula:
C3H5ClO
Formula Weight:
92.52
MOL File:
106-89-8.mol

Epichlorohydrin Properties

Melting point:
-57 °C
Boiling point:
115-117 °C(lit.)
alpha 
-1~+1°(D/20℃)(c=1,CH3OH)
Density 
1.183 g/mL at 25 °C(lit.)
vapor density 
3.2 (vs air)
vapor pressure 
13.8 mm Hg ( 21.1 °C)
refractive index 
n20/D 1.438(lit.)
Flash point:
93 °F
storage temp. 
Refrigerator (+4°C) + Flammables area
solubility 
65.9g/l
form 
Liquid
color 
APHA: ≤20
Specific Gravity
1.183 (20/4℃)
Odor
Pungent, garlic; sweet, pungent; like chloroform.
explosive limit
3.8-21%(V)
Water Solubility 
6 g/100 mL (10 ºC)
FreezingPoint 
-57.2℃
Merck 
14,3611
BRN 
79785
Exposure limits
TLV-TWA(skin) 8 mg/m3 (2 ppm) (ACGIH); STEL (15 min) 19 mg/m3 (5 ppm) (NIOSH).
Stability:
Stability Unstable. Flammable - note wide explosion limits and low flash point. Vapours may flow along surfaces to source of ignition. Contact with strong oxidisers may lead to fire. Incompatible with strong acids, strong bases, strong oxidizing agents, metal salts, amines, aluminium, chlorine and a variety of chlorine compounds, most com
CAS DataBase Reference
106-89-8(CAS DataBase Reference)
NIST Chemistry Reference
Oxirane, (chloromethyl)-(106-89-8)
EPA Substance Registry System
Oxirane, (chloromethyl)-(106-89-8)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
  • NFPA
Hazard Codes  T
Risk Statements  45-10-23/24/25-34-43
Safety Statements  53-45
RIDADR  UN 2023 6.1/PG 2
WGK Germany  3
RTECS  TX4900000
Autoignition Temperature 779 °F
TSCA  Yes
HS Code  2910 30 00
HazardClass  6.1
PackingGroup  II
Hazardous Substances Data 106-89-8(Hazardous Substances Data)
Toxicity LD50 orally in rats: 0.09 g/kg (Smyth, Carpenter)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H226 Flammable liquid and vapour Flammable liquids Category 3 Warning
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
H311 Toxic in contact with skin Acute toxicity,dermal Category 3 Danger P280, P302+P352, P312, P322, P361,P363, P405, P501
H314 Causes severe skin burns and eye damage Skin corrosion/irritation Category 1A, B, C Danger P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H330 Fatal if inhaled Acute toxicity,inhalation Category 1, 2 Danger P260, P271, P284, P304+P340, P310,P320, P403+P233, P405, P501
H331 Toxic if inhaled Acute toxicity,inhalation Category 3 Danger P261, P271, P304+P340, P311, P321,P403+P233, P405, P501
H341 Suspected of causing genetic defects Germ cell mutagenicity Category 2 Warning P201,P202, P281, P308+P313, P405,P501
H350 May cause cancer Carcinogenicity Category 1A, 1B Danger
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
H372 Causes damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 1 Danger P260, P264, P270, P314, P501
H402 Harmful to aquatic life Hazardous to the aquatic environment, acute hazard Category 3
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233 Keep container tightly closed.
P240 Ground/bond container and receiving equipment.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P272 Contaminated work clothing should not be allowed out of the workplace.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P284 Wear respiratory protection.
P310 Immediately call a POISON CENTER or doctor/physician.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P307+P311 IF exposed: call a POISON CENTER or doctor/physician.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.

NFPA 704

Diamond Hazard Value Description
3
3 2
Health   3 Short exposure could cause serious temporary or moderate residual injury (e.g. liquid hydrogen, sulfuric acid, calcium hypochlorite, hexafluorosilicic acid)
Flammability   3 Liquids and solids (including finely divided suspended solids) that can be ignited under almost all ambient temperature conditions . Liquids having a flash point below 22.8 °C (73 °F) and having a boiling point at or above 37.8 °C (100 °F) or having a flash point between 22.8 and 37.8 °C (73 and 100 °F). (e.g. gasoline, acetone)
Instability   2 Undergoes violent chemical change at elevated temperatures and pressures, reacts violently with water, or may form explosive mixtures with water (e.g. white phosphorus, potassium, sodium)
Special  

(NFPA, 2010)

Epichlorohydrin price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 02578 (±)-Epichlorohydrin analytical standard 106-89-8 1ml $33 2018-11-13 Buy
Sigma-Aldrich 45340 (±)-Epichlorohydrin purum, ≥99% (GC) 106-89-8 1l-f $54.5 2018-11-13 Buy
TCI Chemical E0012 Epichlorohydrin >99.0%(GC) 106-89-8 25g $16 2018-11-22 Buy
TCI Chemical E0012 Epichlorohydrin >99.0%(GC) 106-89-8 500g $22 2018-11-22 Buy
Alfa Aesar A15823 (±)-Epichlorohydrin, 99% 106-89-8 500g $26.9 2018-11-13 Buy

Epichlorohydrin Chemical Properties,Uses,Production

Description

Epichlorohydrin is a kind of organochlorine compound as well as epoxide. It can be used as an industrial solvent. It is a highly reactive compound, and can be used for the production of glycerol, plastics, epoxy glues and resins, and elastomers. It can also be used for the production of glycidyl nitrate and alkali chloride, used as the solvent of cellulose, resins, and paint as well as being used as an insect fumigant. In biochemistry, it can be used as a crosslinking agent for the production of Sephdex size-exclusion chromatography resins. However, it is a potential carcinogen, and can cause various kinds of side effects on respiratory tract and kidneys. It can be manufactured through the reaction between allyl chloride with hypochlorous acid as well as alcohols.

References

https://en.wikipedia.org/wiki/Epichlorohydrin
https://pubchem.ncbi.nlm.nih.gov/compound/epichlorohydrin#section=Top

Chemical Properties

colourless liquid

Chemical Properties

Epichlorohydrin is a colorless liquid with a slightly irritating, chloroform-like odor.

Uses

Solvent for natural and synthetic resins, gums, cellulose esters and ethers, paints, varnishes, nail enamels and lacquers, cement for Celluloid. As stabilizer.

Uses

Epichlorohydrin is used to make glycerol,epoxy resins, adhesive, and castings; asderivatives for producing dyes, pharmaceu-ticals, surfactants, and plasticizers; and asa solvent for resins, gums, paints, andvarnishes.

Definition

ChEBI: An epoxide that is 1,2-epoxypropene in which one of the methyl hydrogens is substituted by chlorine.

General Description

A clear colorless liquid with an irritating chloroform-like odor. Density 9.8 lb / gal. Flash point 87°F. Polymerizable. If polymerization takes place inside a closed container, the container is subject to violent rupture. Irritates the skin and respiratory system. Toxic by ingestion. A confirmed carcinogen. Vapors heavier than air. Used to make plastics and as a solvent.

Air & Water Reactions

Highly flammable. Water soluble.

Reactivity Profile

Epichlorohydrin may polymerize exothermically if heated or contaminated. Reacts explosively with aniline. Ignites on contact with potassium tert-butoxide. Reacts with trichloroethylene to give the explosive dichloroacetylene. Violent reaction with sulfuric acid or isopropylamine. Exothermic polymerization on contact with strong acids or bases, zinc, aluminum, aluminum chloride, iron, ferric chloride [Sax, 9th ed., 1996, p. 1469].

Hazard

Toxic by inhalation, ingestion, and skin absorption; strong irritant, a carcinogen. Flammable, moderate fire risk. TLV: 0.5 ppm; animal carcinogen.

Health Hazard

Epichlorohydrin is caustic as both a liquid and gas. Irritation of the eyes and skin, and skin sensitization has been observed. Exposure to epichlorohydrin has caused inflammation of the lungs, asthmatic bronchitis, and liver and kidney damage. In acute poisonings, death may be caused by respiratory paralysis.

Health Hazard

Epichlorohydrin is toxic, carcinogenic, and astrong irritant. Its vapors can produce irrita-tion in the eyes, skin, and respiratory tract.Exposure to high concentration resulted indeath in animals, injuring the central nervoussystem. The liquid can absorb through humanskin, causing painful irritation of subcuta-neous tissues (ACGIH 1986). The symptomsof toxicity from high dosage in test animalswere paralysis of muscles and slow devel-opment of respiratory distress. Long expo-sures at 120 ppm for several hours resultedin lung, kidney, and liver injury in rats(Gage 1959). Ingestion by an oral routecaused tremor, somnolence, and ataxia inmice (NIOSH 1986). The toxic symptomsand lethal doses varied widely with animalspecies. The toxic metabolite of epichlorhy-drin could be ?- chlorohydrin ; thelatter was produced in vitro by rat livermicrosomes (Gingell et al. 1987).
A 25 ppm concentration may be detectableby odor. Exposure at this level may causeburning of the eyes and nose in humans.Above 100 ppm even a short exposure maybe hazardous to humans, causing nausea,dyspnea, lung edema, and kidney injury.
Epichlorohydrin is mutagenic and hasshown carcinogenicity in test animals. Itcaused tumors in the lungs and nose andat gastrointestinal and endocrine sites. Expo-sure to this compound caused harmful repro-ductive effects on fertility and birth defectsin mice.

Fire Hazard

When heated to decomposition, Epichlorohydrin evolves highly toxic fumes of phosgene and carbon monoxide. Reactive and incompatible with strong oxidizers, strong acids, caustics, zinc, aluminum, chlorides of iron and aluminumand compounds with an active hydrogen atom, including water. Unstable, avoid heat, contaminants, strong acids and bases, certain curing agents such as ethylenediamine. Hazardous polymerization may occur.

Fire Hazard

Flash Point (°F): 92 ℃; 100 ℃; Flammable Limits in Air (%): 3.8-21.0; Fire Extinguishing Agents: Alcohol foam, dry chemical, carbon dioxide, water spray; Fire Extinguishing Agents Not To Be Used: Avoid use of dry chemical if fire occurs in container with confined vent; Special Hazards of Combustion Products: Toxic irritating vapors are generated when heated; Behavior in Fire: Containers may explode in fire because of polymerization; Ignition Temperature (°F): 804; Electrical Hazard: Not pertinent; Burning Rate: 2.6 mm/min.

Chemical Reactivity

Reactivity with Water Mild reaction; not likely to be hazardous; Reactivity with Common Materials: No reaction; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Can polymerize in presence of strong acids and bases, particularly when hot; Inhibitor of Polymerization: None used.

Contact allergens

Epoxy resin of the Bisphenol A type is synthesized from epichlorhydrin and bisphenol A. It leads to bisphenol A diglycidyl ether, which is the monomer ofbisphenol-A-based epoxy resins. Sensitization to epichlorhydrin occurs mainly in workers of the epoxy resin industry. Sensitization in individuals not working at epoxy resin plants is rare. It has, however, been described to occur following exposure to a soil fumigant, due to solvent cement, and in a worker in a pharmaceutical plant, in a division of drug synthesis. Epichlorhydrin was used for the production of drugs propranolol and oxprenolol.

Safety Profile

Confirmed carcinogen with experimental carcinogenic data. Poison by ingestion, skin contact, intravenous, and intraperitoneal routes. Moderately toxic by inhalation. An experimental teratogen. Other experimental reproductive effects. Human systemic effects by inhalation: respiratory, nose, and eyes. Human mutation data reported. A skin and eye irritant. A sensitizer. Flammable liquid when exposed to heat or flame. Explosive reaction with andine. Reaction with trichloroethylene forms the explosive dichloroacetylene. Ignition on contact with potassium tertbutoxide. Violent reaction with sulfuric acid or isopropylamine. Exothermic polymerization on contact with strong acids, caustic alkalies, aluminum, aluminum chloride, iron(II1) chloride, or zinc. When heated to decomposition it emits toxic fumes of Cl

Potential Exposure

Epichlorohydrin, an organochlorine, is used in the manufacture of many glycerol and glycidol derivatives and epoxy resins; as a stabilizer in chlorine-containing materials; as an intermediate in the preparation of cellulose esters and ethers, paints, varnishes, nail enamels, and lacquers; as a cement for celluloid. It is used as an intermediate in the manufacture of various drugs. Increased cancer risk.

First aid

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit. Medical observation is recommended for 24 to 48 hours after breathing overexposure, as pulmonary edema may be delayed. As first aid for pulmonary edema, a doctor or authorized paramedic may consider administering a drug or other inhalation therapy

storage

Epichlorohydrin is stored in a well-ventilated,cool place isolated from combustible andoxidizable materials, all acids and bases,and anhydrous metal halides. Protect fromphysical damage. It is shipped in metaldrums.

Shipping

UN2023 Epichlorhydrin, Hazard class: 6.1; Labels: 6.1-Poisonous materials, 3-Flammable liquid.

Purification Methods

Distil epichlorohydrin under atmospheric pressure, heat it on a steam bath with one-quarter its weight of CaO, then decant and fractionally distil it. [Beilstein 17 V 20.]

Incompatibilities

May form explosive mixture with air. Slowly decomposes on contact with water. Heat or strong acids; alkalies, metallic halides, or contaminants can cause explosive polymerization. Violent reaction with strong oxidizers, aliphatic amines; alkanolamines, amines (especially aniline), alkaline earths; chemically active metals (chlorides of aluminum, iron zinc); powdered metals (aluminum, zinc); alcohols, phenols, organic acids; causing fire and explosion hazard. Will pit steel in the presence of water. Thermal decomposition forms highly toxic phosgene gas. May accumulate static electrical charges, and may cause ignition of its vapors.

Waste Disposal

Incineration, preferably after mixing with another combustible fuel. Care must be exercised to assure complete combustion to prevent the formation of phosgene. An acid scrubber is necessary to remove the halo acids produced. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≧100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal

Epichlorohydrin Preparation Products And Raw materials

Raw materials

Preparation Products


Epichlorohydrin Suppliers

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View Lastest Price from Epichlorohydrin manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-04-02 α-Epichlorohydrin Manufacturer; In stock GMP Factory
106-89-8
US $1.00 / KG 1KG High quality manufacturer TOP 3 largest production factory in China Chemwill Asia Co.,Ltd.
2018-09-28 New product 99.9% purity CAS 106-89-8 Epichlorohydrin CAS NO.106-89-8 Manufacturers wholesale
106-89-8
US $1.00 / G 100G 99.9% 50000 tons Hebei Ruishun Trade Co.,Ltd

Epichlorohydrin Spectrum


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