parsalmide
- CAS No.
- 30653-83-9
- Chemical Name:
- parsalmide
- Synonyms
- Parsal;MY-41-6;parsalmide;5-Amino-N-butyl-2-(2-propynyloxy)benzamide;5-Amino-N-butyl-2-(2-propyn-1-yloxy)benzamide;Benzamide, 5-amino-N-butyl-2-(2-propyn-1-yloxy)-
- CBNumber:
- CB2882635
- Molecular Formula:
- C14H18N2O2
- Molecular Weight:
- 246.3
- MDL Number:
- MFCD00864361
- MOL File:
- 30653-83-9.mol
| Melting point | 83-85℃ |
|---|---|
| Boiling point | 389.31°C (rough estimate) |
| Density | 1.107 |
| refractive index | 1.5500 (estimate) |
| pka | pKa (aq soln, 20°) 4.6 ±0.03 |
| FDA UNII | YQH5093J7C |
parsalmide Chemical Properties,Uses,Production
Originator
Parsalmide,Shanghai Lansheng Corporation
Definition
ChEBI: Parsalmide is a member of benzamides.
Manufacturing Process
5-Acetylamino-2-acetoxybenzoyl chloride was obtained by reaction of 5acetylamino-2-acetoxy-benzoic acid with thionylchloride.
5-Acetylamino-N-butyl-2-hydroxybenzamide was produced in the result of treatment of 5-acetylamino-2-acetoxybenzoyl chloride with butylamine in the
presence of sodium hydroxide
5-Acetamino-N-(n-butyl)-2-propargyloxybenzamide was obtained by reaction of 5-acetylamino-N-butyl-2-hydroxybenzamide with propargylbromide in the presence of sodium, isopropyl alcohol and sulfuric acid.
28.8 g (0.1 mole) 5-acetamino-N-(n-butyl)-2-propargyloxybenzamide in 320 ml of 4 N sulfuric acid was heated, under stirring, at 90°-95°C for 2 h. The clear solution was cooled and its pH adjusted to 1 with 1 N NaOH; after filtering, further alkali was subsequently added until a pH of 10 was obtained. At this point the product was separated by filtration and recrystallized from ethanol at 60°C to give 16.6 g (a yield of 68%) of chromatographically pure 5-amino-N-(n-hutyl)-2-propargyloxybenzamide; melting point 85°-87°C.
Therapeutic Function
Muscle relaxant, Antiinflammatory, Analgesic
parsalmide Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
parsalmide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Didu New Material Co., Ltd | 029-63373950 15353716720 | 1052@dideu.com | China | 10004 | 58 |
| Supplier | Advantage |
|---|---|
| Shaanxi Didu New Material Co., Ltd | 58 |