BAY 73-6691
- CAS No.
- 794568-92-6
- Chemical Name:
- BAY 73-6691
- Synonyms
- (R)-BAY 73-6691;BAY 736691,BAY 73 6691;BAY 73-6691 >=98% (HPLC), powder;1-(2-Chlorophenyl)-6-[(2R)-3,3,3-trifluoro-2-methylpropyl]-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidine-4-one;4H-Pyrazolo[3,4-d]pyrimidin-4-one, 1-(2-chlorophenyl)-1,5-dihydro-6-[(2R)-3,3,3-trifluoro-2-methylpropyl]-
- CBNumber:
- CB2972181
- Molecular Formula:
- C15H12ClF3N4O
- Molecular Weight:
- 356.73
- MDL Number:
- MFCD08705319
- MOL File:
- 794568-92-6.mol
- MSDS File:
- SDS
| storage temp. | 2-8°C |
|---|---|
| solubility | DMSO: >20mg/mL |
| form | powder |
| color | off-white |
| FDA UNII | 80ZTV3INTW |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H300-H315-H319-H335-H413 |
| Precautionary statements | P273-P301+P310+P330-P302+P352-P305+P351+P338 |
| Hazard Codes | T,Xi |
| Risk Statements | 25-36/37/38 |
| Safety Statements | 26-45 |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | 3 |
BAY 73-6691 price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | B3561 | BAY 73-6691 ≥98% (HPLC), powder | 794568-92-6 | 5mg | $140.4 | 2024-03-01 | Buy |
| Sigma-Aldrich | B3561 | BAY 73-6691 ≥98% (HPLC), powder | 794568-92-6 | 25mg | $310.8 | 2024-03-01 | Buy |
| TRC | B127603 | BAY 73-6691 | 794568-92-6 | 1mg | $125 | 2021-12-16 | Buy |
| ChemScene | CS-0025654 | BAY 73-6691 99.85% | 794568-92-6 | 5mg | $180 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB159390 | BAY 73-6691 | 794568-92-6 | 10mg | $225 | 2021-12-16 | Buy |
BAY 73-6691 Chemical Properties,Uses,Production
Uses
BAY 73-6691 has been used as a phosphodiesterase 9 inhibitor in ischemic heart samples and in structural studies. It may be used as a PDE 9 inhibitor in neuroblastoma?SH-SY5Y cells.
Biochem/physiol Actions
BAY 73-6691 was characterized in vitro as the first potent and selective inhibitor of phosphodiesterase 9 (PDE9), which is currently under preclinical development for the treatment of Alzheimer′s disease. This compound selectively inhibits human (IC50 = 55 nM) and murine (IC50 = 100 nM) PDE9 activity in vitro and shows only moderate activity against other cyclic nucleotide-specific phosphodiesterases. BAY 73-6691 alone did not significantly increase basal cGMP levels. The PDE9 inhibitor significantly potentiated the cGMP signals generated by sGC activating compounds such as BAY 58-2667 or 5-cyclopropyl-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-4-ylamine (BAY 41-2272) and induced leftward shifts of the corresponding concentration-response curves. The newly generated PDE9 reporter cell line show that BAY 73-6691 is able to efficiently penetrate cells and to inhibit intracellular PDE9 activity.
BAY 73-6691 Preparation Products And Raw materials
Raw materials
Preparation Products
BAY 73-6691 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8012 | 62 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 4009686088 | 3193328036@qq.com | China | 29797 | 68 |
| Twochem Co.Ltd. | 021-58111628 15800915896 | China | 1988 | 58 | |
| Tianjin Kaifu Pharmaceutical Technology Co., Ltd. | 18081075745 | chemflowtech@sina.com | China | 1886 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |