ONO-AE3-208
- CAS No.
- 402473-54-5
- Chemical Name:
- ONO-AE3-208
- Synonyms
- AE 3-208;ONO-AE3-208;AE 3-208;ONO AE3 208;ONO-AE3-208;AE 3-208;ONO AE3 208;4-(4-cyano-2-(2-(4-fluoronaphthalen-1-yl)propanamido)phenyl)butanoic acid;4-Cyano-2-[[2-(4-fluoro-1-naphthalenyl)-1-oxopropyl]amino]Benzenebutanoic acid;4-{4-Cyano-2-[2-(4-fluoro-naphthalen-1-yl)-propionylamino]-phenyl}-butyric acid;Benzenebutanoic acid, 4-cyano-2-[[2-(4-fluoro-1-naphthalenyl)-1-oxopropyl]amino]-
- CBNumber:
- CB92473788
- Molecular Formula:
- C24H21FN2O3
- Molecular Weight:
- 404.43
- MDL Number:
- MFCD13184814
- MOL File:
- 402473-54-5.mol
ONO-AE3-208 price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2076 | ONO-AE3-208 ≥98% (HPLC) | 402473-54-5 | 5mg | $131 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML2076 | ONO-AE3-208 ≥98% (HPLC) | 402473-54-5 | 25mg | $530 | 2024-03-01 | Buy |
| Cayman Chemical | 14522 | ONO-AE3-208 ≥98% | 402473-54-5 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 14522 | ONO-AE3-208 ≥98% | 402473-54-5 | 5mg | $130 | 2024-03-01 | Buy |
| Cayman Chemical | 14522 | ONO-AE3-208 ≥98% | 402473-54-5 | 10mg | $214 | 2024-03-01 | Buy |
ONO-AE3-208 Chemical Properties,Uses,Production
Uses
ONO AE3 208 is a prostaglandin E receptor EP4 antagonist, which inhibits breast cancer metastasis.
Biological Activity
ono-ae3-208 is an antagonist of ep4 [1].ep4 is one of the prostaglandin e2 receptors and is associated with inflammatory disease and cancer such as prostate cancer. as an antagonist of ep4, ono-ae3-208 is expected to be a potential therapy for prostate cancer. in vitro assays show that ono-ae3-208 can suppress the migration and invasion of prostate cancer cells. 10μm of ono-ae3-208 decreases wound healing proportion of pc3 and lncap cell lines in wound-healing assay. and in transwell invasion assay, ono-ae3-208 inhibits cell invasion even at concentration of 0.1μm. ono-ae3-208 is also reported to suppress bone metastasis in vivo [1].since activation of e2 can increase the expression of matrix metalloproteinase (mmp) and release inflammatory cytokines, and then exacerbates abdominal aortic aneurism (aaa) formation, ono-ae3-208 is also used in the studies of aaa formation. it has been proved that ono-ae3-208 can cause the elastic fiber degradation and inhibit aaa formation in vivo in a dose-dependent manner [2].
storage
Store at -20°C
References
[1] song xu, zhengyu zhang, osamu ogawa,takeshi yoshikawa, hiromasa sakamoto, noboru shibasaki, akayuki goto, liming wang, naoki terada. an ep4 antagonist ono-ae3-208 suppresses cell invasion, migration and metastasis of prostate cancer. cell biochem biophys. 2014, april.
[2] utako yokoyama, ryo ishiwata, mei-hua jin, yuko kato, orie suzuki, huiling jin, yasuhiro ichikawa, syun kumagaya, yuzo katayama, takayuki fujita, satoshi okumura, motohiko sato, yukihiko sugimoto, hiroki aoki, shinichi suzuki, munetaka masuda, susumu minamisawa, yoshihiro ishikawa. inhibition of ep4 signaling attenuates aortic aneurysm formation. plos one. 2012, may. 7, 5, e36724.
ONO-AE3-208 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| TopScience Biochemical | 00852-68527855 | info@itopbiochem.com | China Hong Kong | 902 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33349 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |