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Description History Physical properties Safety description chemical properties ε-Polylysine
Epsilon-polylysine structure
Chemical Name:
ε-PL;ε-Polylysine;E-Polylysine;ε-poly-L-lysin;ε-Poly-L-lysine;ε-Polylysine,ε-PL;epsilon-Polylysin;ε-poly-L-lysineHC;EPSILON-POLYLYSINE;Poly epsilon L-lysine
Molecular Formula:
Formula Weight:
MOL File:

Epsilon-polylysine Properties

Melting point:
172 °C

Epsilon-polylysine Chemical Properties,Uses,Production


ε-Polylysine is a light yellow powder with strong hygroscopicity and slightly bitter taste. It is a linear polymer of lysine. It is produced by streptomyces fermentation and has a broad-spectrum antibacterial effect. ε-polylysine is polymerized by 25-30 lysine groups, which is relatively stable to pH and heat. Its antibacterial effect is related to the degree of polymerization and the environment. The molecular weight of polylysine is between 3600-4300 which has the best antibacterial activity.


In 1977, Japanese scholars S. Shima and H. Sakai, in the process of screening Dragendo~Positive (DP) substances from microorganisms, discovered that a strain of actinomycete No.346 can produce a large amount of stable DP substances. The analysis and structural analysis of the hydrolysate confirmed that the DP substance is a homopolymer of 25-30 lysine residues. A homologous amino acid polymer formed by NH2 condensation, so it is called ε-Poly-L-lysine (ε-Poly-L-lysine for short ε-PL).

Physical properties

ε-PL pure product is light yellow powder, slightly bitter, strong hygroscopicity, and slightly bitter. It is easily soluble in water, slightly soluble in ethanol, but insoluble in organic solvents such as ethyl acetate and ether. It has high stability and antibacterial effect.


ε-PL enters the human body and is converted into lysine through digestion and decomposition. Lysine is one of the eight essential amino acids for the human body. It is an amino acid allowed to be added to food and is non-toxic and harmless to the human body. Therefore, ε -PL as a nutritional bacteriostatic agent, its safety is much higher than other chemical preservatives.


Epsilon-polylysine (ε-PL) is an antimicrobial commercially produced by Streptomyces fermentation and widely used in Asian countries for food preservation. epsilon-polylysine is approved for food use in Japan as an antimicrobial preservative.
Epsilon-polylysine (ε-PL) is a small cationic isopeptide made from the essential amino acid L-lysine. It exhibits antimicrobial activity against a wide spectrum of bacteria, yeast, and fungi and is heat stable and active in different food matrices. ε-PL has been a popular food preservative in Japan since the late 1980s, followed by Korea and China, and has been given Generally Regarded As Safe (GRAS) status in the USA. As a secondary metabolite, ε-PL was first discovered from the soil bacterium Streptomyces albulus, which is still used in its commercial production. Later, more producers of ε-PL were identified from the family of Streptomycetaceae, including the genera Streptomyces and Kitasatospora, and ergot fungi. ε-PL is synthesized by a cell-membrane-bound nonribosomal peptide synthetase (NRPS)-like enzyme named ε-PL synthetase (Pls).
Distribution of Epsilon-Polylysine Synthetases in Coryneform Bacteria Isolated from Cheese and Human Skin

chemical properties

Epsilon-polylysine is produced in Japan, and levels as low as 5 ppm have been found to be inhibitory, especially of some Gram-positive bacteria. It is water soluble, effective over a wide pH range, and is degraded to lysine by proteases.


ε-Polylysine (ε-poly-L-lysine, EPL) is typically produced as a homopolypeptide of approximately 25–30 L-lysine residues.
Epsiliseen®- H is a natural antimicrobial agent with ultra-high concentration of E-Polylysine, used in food, cosmeceutical and pharmaceutical applications.
ε-Polylysine (ε-poly-L-lysine), the main active ingredient in Epsiliseen®, is a small polypeptide of the essential amino acid L-lysinethat is produced by bacterial fermentation; the natural fermentation is only observed in strains of bacteria in the genus Streptomyces.
ε-Polylysine is commercially used as a food preservative in Japan, the republic of Korea and in the USA. Food products containing polylysine are mainly found in Japan. The use of polylysine is common in food applications like: boiled rice, cooked vegetables, soups, noodles and sliced fish (sushi).

Chemical Properties

from Streptomyces albulus.


ChEBI: A macromolecule composed of repeating L-lysyl units joined via 1,6-amide linkages.

Epsilon-polylysine Preparation Products And Raw materials

Raw materials

Preparation Products

Epsilon-polylysine Suppliers

Global( 95)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Zhengzhou bainafo bioengineering co., ltd
86-371-67882790 CHINA 3 58
Henan DaKen Chemical CO.,LTD.
+86-371-66670886 China 21067 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 22607 55
career henan chemical co
+86-371-86658258 CHINA 29968 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282 China 4940 58
Hubei xin bonus chemical co. LTD
027-59338440 CHINA 23035 58
BOC Sciences
1-631-614-7828 United States 19753 58
Chongqing Chemdad Co., Ltd
+86-13650506873 CHINA 37282 58
Zhuozhou Wenxi import and Export Co., Ltd
+8613111626072 (WhatsApp)
Wechat: +8613111626072 Wickr me: waynehu CHINA 13187 58
Hefei TNJ Chemical Industry Co.,Ltd.
0551-65418697 CHINA 37441 58

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View Lastest Price from Epsilon-polylysine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-07-26 epsilon-Polylysin
US $1.00 / KG 1KG ≥98.00% 500kg/month WUHAN FORTUNA CHEMICAL CO., LTD
US $0.00-0.00 / Kg/Drum 1KG 98%min 500KG WUHAN FORTUNA CHEMICAL CO., LTD
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

28211-04-3(Epsilon-polylysine)Related Search:

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