4-(3-FORMYL-4-HYDROXYPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- CAS No.
- 343306-50-3
- Chemical Name:
- 4-(3-FORMYL-4-HYDROXYPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- Synonyms
- 1-Boc-4-(3-ForMyl-4-hydroxyphenyl)piperazine;tert-Butyl 4-(3-forMyl-4-hydroxyphenyl)piperazine-1-carboxylate;4-(3-FORMYL-4-HYDROXYPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-Piperazinecarboxylic acid, 4-(3-formyl-4-hydroxyphenyl)-, 1,1-dimethylethyl ester
- CBNumber:
- CB32452798
- Molecular Formula:
- C16H22N2O4
- Molecular Weight:
- 306.36
- MDL Number:
- MFCD09909715
- MOL File:
- 343306-50-3.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Tert-Butyl4-(3-formyl-4-hydroxyphenyl)piperazine-1-carboxylate | 9787DA | 250mg | $189 |
| 1-BOC-4-(3-FORMYL-4-HYDROXYPHENYL)PIPERAZINE 95.00% | CHM0380626 | 5MG | $504.3 |
| tert-butyl4-(3-formyl-4-hydroxyphenyl)piperazine-1-carboxylate 95% | CM125004 | 5g | $832 |
| tert-Butyl4-(3-formyl-4-hydroxyphenyl)piperazine-1-carboxylate 97% | A254583 | 5g | $857 |
| tert-Butyl4-(3-formyl-4-hydroxyphenyl)piperazine-1-carboxylate 95+% | CD11139817 | 5g | $881 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319 |
| Precautionary statements | P261-P305+P351+P338 |
4-(3-FORMYL-4-HYDROXYPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AK Scientific | 9787DA | Tert-Butyl4-(3-formyl-4-hydroxyphenyl)piperazine-1-carboxylate | 343306-50-3 | 250mg | $189 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0380626 | 1-BOC-4-(3-FORMYL-4-HYDROXYPHENYL)PIPERAZINE 95.00% | 343306-50-3 | 5MG | $504.3 | 2021-12-16 | Buy |
| Chemenu | CM125004 | tert-butyl4-(3-formyl-4-hydroxyphenyl)piperazine-1-carboxylate 95% | 343306-50-3 | 5g | $832 | 2021-12-16 | Buy |
| Ambeed | A254583 | tert-Butyl4-(3-formyl-4-hydroxyphenyl)piperazine-1-carboxylate 97% | 343306-50-3 | 5g | $857 | 2021-12-16 | Buy |
| Crysdot | CD11139817 | tert-Butyl4-(3-formyl-4-hydroxyphenyl)piperazine-1-carboxylate 95+% | 343306-50-3 | 5g | $881 | 2021-12-16 | Buy |
4-(3-FORMYL-4-HYDROXYPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties,Uses,Production
Synthesis
1761-61-1
57260-71-6
343306-50-3
General procedure: 5-bromo-2-hydroxybenzaldehyde (1000 g, 4.97 mol, 1 eq.) and tert-butyl 1-piperazinecarboxylate (1065.4 g, 5.72 mol, 1.1 eq.) were added to a reactor protected by nitrogen and palladium acetate (11.0 g, 0.049 mol, 0.01 eq.) and tri-tert-butylphosphine (10.0 g, 0.049 mol, 0.01 equiv) to a solution of toluene (0.3 L). Sodium tert-butoxide (1052.4 g, 10.9 mol, 2.2 eq.) was subsequently added. The reaction mixture was stirred at 42 °C for 22 h to form a reddish brown slurry. Upon completion of the reaction, a mixture of distilled water (8 L) and glacial acetic acid (800 mL) was added (pH adjusted to 5-6) and stirred for 10 min. The organic phase was separated and washed twice with distilled water (2 x 8L). The organic phase was dried by adding sodium sulfate (2.5 kg), stirred for 30 min and filtered. The dark orange organic phase was weighed (9.65 kg) and an aliquot (100 g) was concentrated under vacuum to give a dark orange oil. The oily substance was purified by column chromatography (silica gel, height: 30 cm, diameter: 4 cm, eluent: methyl tert-butyl ether/heptane 1:1) to afford the target compound tert-butyl 4-(3-formyl-4-hydroxyphenyl)piperazine-1-carboxylate as yellow crystals (8.9 g). The total yield was 56% based on an aliquot. Mass spectrum (ES+): 307 (M+H).
References
[1] Patent: EP2110374, 2009, A1. Location in patent: Page/Page column 30
[2] Bioorganic and Medicinal Chemistry, 2004, vol. 12, # 18, p. 4843 - 4852
4-(3-FORMYL-4-HYDROXYPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
4-(3-FORMYL-4-HYDROXYPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| SynAsst Chemical. | 021-60343070 | China | 12740 | 55 | |
| BioPharmaMatrix,Inc. | 0510-86010668 | sales@biopharmamatrix.com | China | 4743 | 55 |
| Dezhou LonWel Pharmaceutical Technology Co., Ltd. | 13761310616 | 39324283@qq.com | China | 1627 | 58 |
| Aikon International Limited | 025-58859352 18068836627 | sales01@aikonchem.com | China | 16027 | 58 |
| Shanghai Jizhi Biochemical Technology Co. Ltd. | 4009004166/18616739031 18616739031 | 3007523370@qq.com | China | 52687 | 58 |
| Shanghai Moss Medicine Technology Co., Ltd. | +86-188369842 +86-15618151133 | 188369842@qq.com | China | 1959 | 58 |
| Cool Pharm, Ltd | 021-58581007 18019463053 | sales@coolpharm.com | China | 5666 | 58 |
