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tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate

tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate Structure
tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate structure
CAS No.
1147557-97-8
Chemical Name:
tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate
Synonyms
2-Boc-6-hydroxy-2-aza-spi...;2-Boc-6-hydroxy-2-aza-spiro[3.3]heptane;6-oxo-2-azaspiro[3.3]heptane-2-carboxylate;6-Hydroxy-2-azaspiro[3.3]heptane, N-BOC protected;tert-Butyl 2-hydroxy-6-azaspiro[3.3]heptane-6-carboxylate;tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate;1,1-Dimethylethyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate;6-Hydroxy-2-azaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester;tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate ISO 9001：2015 REACH;2-Azaspiro[3.3]heptane-2-carboxylic acid, 6-hydroxy-, 1,1-diMethylethyl ester
CBNumber:
CB32470891
Molecular Formula:
C11H19NO3
Molecular Weight:
213.27
MDL Number:
MFCD15071431
MOL File:
1147557-97-8.mol
Last updated:2025-07-24 18:13:42
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tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate Properties

Melting point 127-129℃
Boiling point 316.6±42.0 °C(Predicted)
Density 1.17
storage temp. 2-8°C
solubility DMSO (Slightly), Methanol (Slightly)
pka 14.84±0.20(Predicted)
form Solid
color White to Off-White
InChI InChI=1S/C11H19NO3/c1-10(2,3)15-9(14)12-6-11(7-12)4-8(13)5-11/h8,13H,4-7H2,1-3H3
InChIKey UMXXHZDEAZUQKZ-UHFFFAOYSA-N
SMILES C1C2(CC(O)C2)CN1C(OC(C)(C)C)=O

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
HS Code  2934999090

tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate price More Price(36)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical D6214 tert-Butyl 6-Hydroxy-2-azaspiro[3.3]heptane-2-carboxylate min. 98.0 % 1147557-97-8 1G $75 2025-07-31 Buy
TRC B809463 tert-​Butyl6-​Hydroxy-​2-​azaspiro[3.3]​heptane-​2-​carboxylate 1147557-97-8 250mg $95 2021-12-16 Buy
SynQuest Laboratories 4H56-1-8J tert-Butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate 95% 1147557-97-8 1g $96 2021-12-16 Buy
Synthonix H6094 6-Hydroxy-2-azaspiro[3.3]heptane-2-carboxylicacidtert-butylester 97.0% 1147557-97-8 5g $150 2021-12-16 Buy
Apolloscientific OR301181 6-Hydroxy-2-azaspiro[3.3]heptane,N-BOCprotected 1147557-97-8 1g $87 2021-12-16 Buy
Product number Packaging Price Buy
D6214 1G $75 Buy
B809463 250mg $95 Buy
4H56-1-8J 1g $96 Buy
H6094 5g $150 Buy
OR301181 1g $87 Buy

tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate Chemical Properties,Uses,Production

Uses

tert-?Butyl 6-?Hydroxy-?2-?azaspiro[3.3]?heptane-?2-?carboxylate is a reactant used in the synthesis of pharmaceuticals such as CNS penetrant CXCR2 antagonists for the potential treatment of CNS demyelinating.

Synthesis

tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate

1181816-12-5

tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate

1147557-97-8

Step 8: Synthesis of tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate At 0 °C and under nitrogen protection, tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate (507 mg, 2.4 mmol) was dissolved in methanol (5.0 mL) and sodium borohydride (182 mg, 4.8 mmol) was added slowly. The reaction mixture was stirred at 0 °C for 30 min. After completion of the reaction, the solvent was concentrated in vacuum by rotary evaporator to give the crude product. Saturated sodium bicarbonate solution (30 mL) was added to the crude product and the aqueous phase was extracted with dichloromethane (4 x 30 mL). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated in vacuum to afford tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate (5 mg, 100% yield) as a white solid.1H NMR (300 MHz, CDCl3): δ 4.18 (m, 1H), 3.88 (d, 4H), 2.53 (m, 2H), 2.08 (m. 2H), 1.42 (s, 9H).

References

[1] Patent: WO2013/13308, 2013, A1. Location in patent: Paragraph 00178-00180
[2] Journal of Medicinal Chemistry, 2017, vol. 60, # 13, p. 5663 - 5672
[3] Patent: CN106565706, 2017, A. Location in patent: Paragraph 0179; 0180; 0181
[4] Patent: EP3281942, 2018, A1. Location in patent: Paragraph 0105; 0106
[5] Patent: WO2018/133858, 2018, A1. Location in patent: Paragraph 00221

tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate synthesis

1181816-12-5
1147557-97-8
Synthesis of tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate from tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate

tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate Preparation Products And Raw materials

Raw materials

tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate Methanol Sodium borohydride

Preparation Products

6-Amino-2-aza-spiro[3.3]heptane-2-carboxylic acid tert-butyl ester tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate

tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate Suppliers

Global( 140)Suppliers
Supplier Tel Email Country ProdList Advantage
BTC Nantong Pharmaceuticals Technology Co.,Ltd
+8618068193575 sales4@btcpharm.com China 251 58
Jinan Carbotang Biotech Co.,Ltd. 		+8615866703830 figo.gao@foxmail.com China 8497 58
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 21193 58
Chengdu Feibo Pharm Technology Co., Ltd 		+86 028-84641798 15982321820 abby@arkpharm.com China 10922 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49733 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29804 58
Jinan Liheng Biotechnology Co., Ltd. 		15865262812 info@lihengpharm.com CHINA 938 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051 joe@yuhengpharm.com CHINA 21142 58
Hubei Ipure Biology Co., Ltd 		+8613367258412 ada@ipurechemical.com China 10244 58
Supplier Advantage
BTC Nantong Pharmaceuticals Technology Co.,Ltd
58
Jinan Carbotang Biotech Co.,Ltd. 		58
Accela ChemBio Inc. 		58
Chengdu Feibo Pharm Technology Co., Ltd 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
Jinan Liheng Biotechnology Co., Ltd. 		58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		58
Hubei Ipure Biology Co., Ltd 		58

View Lastest Price from tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate pictures 2025-04-04 tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate
1147557-97-8
 US $0.00-0.00 / KG 1KG 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate pictures 2024-02-26 tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate
1147557-97-8
 US $0.00-0.00 / kg 1kg 99% Kgs BTC Nantong Pharmaceuticals Technology Co.,Ltd
tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate pictures 2022-07-29 tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate
1147557-97-8
 US $1.10 / g 1g 99.00% 100 Tons Min Dideu Industries Group Limited

tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate Spectrum

tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate(1147557-97-8)1HNMRtert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate(1147557-97-8)FT-IR

1147557-97-8(tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate)Related Search:

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tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate 2-Boc-6-hydroxy-2-aza-spi... 2-Boc-6-hydroxy-2-aza-spiro[3.3]heptane 6-Hydroxy-2-azaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester 2-Azaspiro[3.3]heptane-2-carboxylic acid, 6-hydroxy-, 1,1-diMethylethyl ester 6-Hydroxy-2-azaspiro[3.3]heptane, N-BOC protected tert-Butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate, 2-(tert-Butoxycarbonyl)-6-hydroxy-2-azaspiro[3.3]heptane tert-Butyl 2-hydroxy-6-azaspiro[3.3]heptane-6-carboxylate tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate ISO 9001：2015 REACH 1,1-Dimethylethyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate 6-Hydroxy-2-azaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester - [H6094] 1147557-97-8