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2'-O-(2-Methoxyethyl)cytidine

2'-O-(2-Methoxyethyl)cytidine structure

CAS No.: 223777-16-0

Chemical Name:: 2'-O-(2-Methoxyethyl)cytidine

Synonyms: 2'-MOE-C;2'-MOE-rC;2'-O-MOE-rC;2'-O-MOE-Cr;2'-MOE-Cytidine;2'-O-MOE Cytidine;2'-O-(2-mthoxyethyl)Cytidine;2'-O-(2-Methoxyethyl)cytidine;2'-O-(2-Methoxyethyl)cytidine;Cytidine, 2'-O-(2-methoxyethyl)-

CBNumber:: CB32510559

Molecular Formula:: C12H19N3O6

Molecular Weight:: 301.3

MDL Number:: MFCD17215637

MOL File:: 223777-16-0.mol

Last updated:2023-11-27 09:19:11

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2'-O-(2-Methoxyethyl)cytidine Properties

Boiling point	535.3±60.0 °C(Predicted)
Density	1.57±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO : 250 mg/mL (829.74 mM)
pka	13.36±0.70(Predicted)
InChI	InChI=1S/C12H19N3O6/c1-19-4-5-20-10-9(17)7(6-16)21-11(10)15-3-2-8(13)14-12(15)18/h2-3,7,9-11,16-17H,4-6H2,1H3,(H2,13,14,18)/t7-,9-,10-,11-/m1/s1
InChIKey	YKOGMMXZKKVMBT-QCNRFFRDSA-N
SMILES	OC[C@H]1O[C@@H](N2C=CC(N)=NC2=O)[C@H](OCCOC)[C@@H]1O

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

2'-O-(2-Methoxyethyl)cytidine price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	M262570	2''-O-(2-Methoxyethyl)cytidine	223777-16-0	25mg	$1760	2021-12-16	Buy
American Custom Chemicals Corporation	NUC0002420	2'-O-(2-METHOXYETHYL)CYTIDINE 95.00%	223777-16-0	0.25G	$786	2021-12-16	Buy
Biosynth Carbosynth	NM16315	2'-O-(2-Methoxyethyl)cytidine	223777-16-0	500mg	$115	2021-12-16	Buy
AK Scientific	1312AB	2'-O-(2-Methoxyethyl)-cytidine	223777-16-0	1g	$320	2021-12-16	Buy
AK Scientific	1312AB	2'-O-(2-Methoxyethyl)-cytidine	223777-16-0	2g	$455	2021-12-16	Buy

Product number	Packaging	Price	Buy
M262570	25mg	$1760	Buy
NUC0002420	0.25G	$786	Buy
NM16315	500mg	$115	Buy
1312AB	1g	$320	Buy
1312AB	2g	$455	Buy

2'-O-(2-Methoxyethyl)cytidine Chemical Properties,Uses,Production

Description

2'-O-(2-Methoxyethyl)-cytidine is a cytidine derivative that can be used as a building block for crosslinking oligonucleotides. 2'-O-(2-Methoxyethyl)-cytidine is also used as a texturizing agent in food products.

Uses

A cytidine derivative as building blocks for cross-linking oligonucleotides.

Synthesis

2'-O-(2-Methoxyethyl)uridine could be converted into the corresponding cytidine derivative (2'-O-(2-Methoxyethyl)cytidine) by the 4-nitrophenylation[1]. 2'-O-(2-Methoxyethyl)uridine, l-methylpyrrolidine, chlorotrimethylsilane and dry acetonitrile were stirred together at rt. After 1 h, the reaction mixture was cooled to 0 ℃, and trifluoroacetic anhydride was added dropwise over 5 min. After a further period of 30 rain at 0 ℃, 4-nitrophenol was added to the stirred reactants which were maintained at 0 °C. After 3 h, the products were poured into saturated aqueous sodium hydrogen carbonate, and the resulting mixture was extracted with dichloromethane. The combined organic layers were dried, and evaporated under reduced pressure. Concentrated aqueous ammonia was added to a stirred solution of the residue in dioxane, contained in a sealed flask that was then heated at 55°C for 24 h. The resulting yellow solution was concentrated under reduced pressure and the residue was evaporated with absolute ethanol. The products were fractionated by short column chromatography on silica gel and were evaporated under reduced pressure to give 2'-O-(2-Methoxyethyl)cytidine as an off-white solid.

References

[1] Urtzi et al. "Conversion of uridine into 2′-O-(2-methoxyethyl)uridine and 2′-O-(2-methoxyethyl)cytidine." Tetrahedron (1999).

2'-O-(2-Methoxyethyl)cytidine synthesis

Synthesis of 2'-O-(2-Methoxyethyl)cytidine from 2'-O-(2-Methoxyethyl)uridine

2'-O-(2-Methoxyethyl)cytidine Preparation Products And Raw materials

Raw materials

2'-O-(2-Methoxyethyl)uridine 1-Methylpyrrolidine

Preparation Products

2'-O-(2-Methoxyethyl)cytidine Suppliers

Global( 80)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Yunbio Tech Co.,Ltd.	+86-010-60605551 +86-18046518538	yunbiochem@126.com	China	321	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10248	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	7019	58
Nanjing Baifuli Technology Co., Ltd.	+86-15335185688	sales@unisyn.cn	CHINA	332	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Antai Fine Chemical Technology Co.,Limited	18503026267	info@antaichem.com	CHINA	9641	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5738	58
Zhengzhou Alfa Chemical Co.,Ltd	+8618530059196	sale04@alfachem.cn	China	12550	58
BOC Sciences	+16314854226	inquiry@bocsci.com	United States	19743	58

Supplier	Advantage
Yunbio Tech Co.,Ltd.	58
Shenzhen Nexconn Pharmatechs Ltd	58
Jinan Carbotang Biotech Co.,Ltd.	58
Nanjing Baifuli Technology Co., Ltd.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Antai Fine Chemical Technology Co.,Limited	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58
Zhengzhou Alfa Chemical Co.,Ltd	58
BOC Sciences	58

View Lastest Price from 2'-O-(2-Methoxyethyl)cytidine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-02-06	2'-O-(2-Methoxyethyl)cytidine 223777-16-0	US $0.00-0.00 / KG	1KG	99%	200KG per month	Yunbio Tech Co.,Ltd.
2023-04-04	2'-O-(2-Methoxyethyl)cytidine 223777-16-0	US $0.00-0.00 / kg	1kg	98%	500kg per month	Zhejiang Hengkang Pharmaceutical Co., Ltd.
2023-03-22	2'-O-(2-methoxyethyl)-Cytidine；2’-MOE-C 223777-16-0	US $100.00 / kg	0.009999999776482582kg	99%	5tons	SHANGHAI NOVRIBO BIOTECH

2'-O-(2-Methoxyethyl)cytidine
223777-16-0
US $0.00-0.00 / KG
99%
Yunbio Tech Co.,Ltd.

2'-O-(2-Methoxyethyl)cytidine
223777-16-0
US $0.00-0.00 / kg
98%
Zhejiang Hengkang Pharmaceutical Co., Ltd.

2'-O-(2-methoxyethyl)-Cytidine；2’-MOE-C
223777-16-0
US $100.00 / kg
99%
SHANGHAI NOVRIBO BIOTECH

223777-16-0(2'-O-(2-Methoxyethyl)cytidine)Related Search:

2'-O-Methylcytidine DMT-2μ-O-Me-rG(ib) amidite 2’-O-Methyl-rA(N-Bz)phosphoramidite DMT-2′Fluoro-dU Phosphoramidite 2'-O-MOE-A(Bz)-3'-phosphoramidite

2'-O-(2-Methoxyethyl)-5-methyluridine N-blocked-5'-O-DMT-2'-O-Me CED cytosine phosphoramidite N4-Benzoyl-5'-O-DMT-2'-O-methyl-5-methylcytidine 3'-CE phosphoramidite Dmt-2'-f-dc(ac) amidite 2'-O-Methyladenosine

2'-O-Methylguanosine 2'-O-(2-Methoxyethyl)uridine DMT-2'-O-MOE-rU Phosphoramidite 2'-O-MOE-ADENOSINE 2'-OMe-ibu-G Phosphoramidite

2'-O-(2-Methoxyethyl)guanosine

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2'-O-(2-Methoxyethyl)cytidine 2'-O-MOE Cytidine 4-AMINO-1-[(2R,3R,4R,5R)-4-HYDROXY-5-(HYDROXYMETHYL)-3-(2-METHOXYETHOXY)OXOLAN-2-YL]PYRIMIDIN-2-ONE 2'-O-(2-Methoxyethyl)-cytidine, >97% 4-AMINO-1-[4-HYDROXY-5-(HYDROXYMETHYL)-3-(2-METHOXYETHOXY)OXOLAN-2-YL]PYRIMIDIN-2-ONE 4-amino-1-[(2R,3S,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)tetrahydrofuran-2-yl]pyrimidin-2-one Cytidine, 2'-O-(2-methoxyethyl)- 2'-O-MOE-rC 2'-MOE-Cytidine 2'-O-MOE-Cr 2'-MOE-rC 2'-MOE-C 4-amino-1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)tetrahydrofuran-2-yl]pyrimidin-2-one 2'-O-(2-mthoxyethyl)Cytidine 2'-O-(2-Methoxyethyl)cytidine 223777-16-0 Bases & Related Reagents Carbohydrates & Derivatives Heterocycles Nucleotides