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2-broMo-5-(difluoroMethoxy)pyridine

2-broMo-5-(difluoroMethoxy)pyridine Structure
2-broMo-5-(difluoroMethoxy)pyridine structure
CAS No.
845827-14-7
Chemical Name:
2-broMo-5-(difluoroMethoxy)pyridine
Synonyms
2-Bromo-5-(difluoromethoxy);2-broMo-5-(difluoroMethoxy)pyridine;Pyridine,2-bromo-5-(difluoromethoxy)-
CBNumber:
CB32663802
Molecular Formula:
C6H4BrF2NO
Molecular Weight:
224
MDL Number:
MFCD13185842
MOL File:
845827-14-7.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:52
Product description Number Pack Size Price
2-Bromo-5-(difluoromethoxy)pyridine B292505 250mg $330
2-Bromo-5-(difluoromethoxy)pyridine PC421030 500mg $65
2-Bromo-5-(difluoromethoxy)pyridine 4H07-9-42 500mg $104
2-Bromo-5-(difluoromethoxy)pyridine PC421030 1g $112
2-Bromo-5-(difluoromethoxy)pyridine 7659DA 100mg $154
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2-broMo-5-(difluoroMethoxy)pyridine Properties

Boiling point 235.2±35.0 °C(Predicted)
Density 1.670±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka -3.29±0.10(Predicted)
form liquid
color Pale yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P271-P280
HS Code  2933399990

2-broMo-5-(difluoroMethoxy)pyridine price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC B292505 2-Bromo-5-(difluoromethoxy)pyridine 845827-14-7 250mg $330 2021-12-16 Buy
Apolloscientific PC421030 2-Bromo-5-(difluoromethoxy)pyridine 845827-14-7 500mg $65 2021-12-16 Buy
SynQuest Laboratories 4H07-9-42 2-Bromo-5-(difluoromethoxy)pyridine 845827-14-7 500mg $104 2021-12-16 Buy
Apolloscientific PC421030 2-Bromo-5-(difluoromethoxy)pyridine 845827-14-7 1g $112 2021-12-16 Buy
AK Scientific 7659DA 2-Bromo-5-(difluoromethoxy)pyridine 845827-14-7 100mg $154 2021-12-16 Buy
Product number Packaging Price Buy
B292505 250mg $330 Buy
PC421030 500mg $65 Buy
4H07-9-42 500mg $104 Buy
PC421030 1g $112 Buy
7659DA 100mg $154 Buy

2-broMo-5-(difluoroMethoxy)pyridine Chemical Properties,Uses,Production

Synthesis

2-Bromo-5-hydroxypyridine

55717-45-8

Sodium chlorodifluoroacetate

1895-39-2

2-broMo-5-(difluoroMethoxy)pyridine

845827-14-7

Using 6-bromopyridin-3-ol (1.2 g, 6.9 mmol) and sodium difluorochloroacetate (2.1 g, 13.8 mmol) as raw materials, potassium carbonate (1.24 g, 8.97 mmol) was added in anhydrous DMF (10 ml) and the mixture was stirred and reacted for 20 hrs at 80 °C. After completion of the reaction, it was cooled to room temperature and the reaction mixture was partitioned between EtOAc and water. The aqueous layer was back-extracted with EtOAc, the organic phases were combined, dried over anhydrous sodium sulfate and concentrated. The crude product was purified by chromatography on a Redi-Sep pre-populated silica gel column (40 g) using a gradient elution with hexane solution from 0 to 10% EtOAc to afford 2-bromo-5-difluoromethoxypyridine (0.89 g, 4.0 mmol, 58% yield) as a colorless oil.ESI-MS (M+1) m/z: 225.8.

References

[1] Journal of Medicinal Chemistry, 2010, vol. 53, # 23, p. 8421 - 8439
[2] Patent: US2013/225552, 2013, A1. Location in patent: Paragraph 0902
[3] Patent: EP1741703, 2007, A1. Location in patent: Page/Page column 73
[4] Patent: US2018/37594, 2018, A1. Location in patent: Paragraph 0280-0283
[5] Patent: US2014/249104, 2014, A1. Location in patent: Page/Page column

2-broMo-5-(difluoroMethoxy)pyridine Preparation Products And Raw materials

Raw materials

2-Bromo-5-hydroxypyridine Sodium chlorodifluoroacetate N,N-Dimethylformamide Potassium carbonate

Preparation Products

2-broMo-5-(difluoroMethoxy)pyridine Suppliers

Global( 64)Suppliers
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Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 21193 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49977 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051 joe@yuhengpharm.com CHINA 21142 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 +8617705817739 info@dycnchem.com China 52705 58
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Suzhou ARTK Medchem Co., Ltd. 		+8618118463618 sales1@artkmedchem.com China 39021 58
Cochemical Co. Ltd. 		+86-029-86115547 +86-17791676824 sales@cochemical.com China 3952 58
NANJING YINGWEN BIOTECHNOLOGY CO LTD 		+8613382787392 sales@aeechem.com China 10000 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
Supplier Advantage
Accela ChemBio Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
PT CHEM GROUP LIMITED 		58
Aladdin Scientific 		58
Suzhou ARTK Medchem Co., Ltd. 		58
Cochemical Co. Ltd. 		58
NANJING YINGWEN BIOTECHNOLOGY CO LTD 		58
Amadis Chemical Company Limited 		58

2-broMo-5-(difluoroMethoxy)pyridine Spectrum

2-broMo-5-(difluoroMethoxy)pyridine(845827-14-7)1HNMR2-broMo-5-(difluoroMethoxy)pyridine(845827-14-7)19FNMR

845827-14-7(2-broMo-5-(difluoroMethoxy)pyridine)Related Search:

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2-broMo-5-(difluoroMethoxy)pyridine Pyridine,2-bromo-5-(difluoromethoxy)- 2-Bromo-5-(difluoromethoxy) 845827-14-7