LM 22A4
- CAS No.
- 37988-18-4
- Chemical Name:
- LM 22A4
- Synonyms
- BD2-4;LM 22A4;LM 22A4; LM 22A-4;N,N',N''-Tris(beta-hydroxyethyl)trimesamide;N1,N3,N5-Tris(2-hydroxyethyl)-1,3,5-benzenetricarboxamide;1,3,5-Benzenetricarboxamide, N1,N3,N5-tris(2-hydroxyethyl)-;1-N,3-N,5-N-TRIS(2-HYDROXYETHYL)BENZENE-1,3,5-TRICARBOXAMIDE;LM-22A-4,Inhibitor,Trk Receptor,inhibit,LM22A4,LM22A-4,Tropomyosin related kinase receptor,LM22A 4
- CBNumber:
- CB32682689
- Molecular Formula:
- C15H21N3O6
- Molecular Weight:
- 339.34
- MDL Number:
- MFCD00382831
- MOL File:
- 37988-18-4.mol
| storage temp. | 2-8°C |
|---|---|
| solubility | H2O: soluble2mg/mL, clear (warmed) |
| form | powder |
| color | white to beige |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month. |
| FDA UNII | 5GCL3P6AF5 |
LM 22A4 price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0848 | LM22A-4 ≥98% (HPLC) | 37988-18-4 | 5mg | $71.4 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0848 | LM22A-4 ≥98% (HPLC) | 37988-18-4 | 25mg | $386 | 2024-03-01 | Buy |
| Cayman Chemical | 22082 | LM22A-4 ≥98% | 37988-18-4 | 5mg | $62 | 2024-03-01 | Buy |
| Cayman Chemical | 22082 | LM22A-4 ≥98% | 37988-18-4 | 10mg | $109 | 2024-03-01 | Buy |
| Cayman Chemical | 22082 | LM22A-4 ≥98% | 37988-18-4 | 25mg | $254 | 2024-03-01 | Buy |
LM 22A4 Chemical Properties,Uses,Production
Description
LM22A-4 (37988-18-4) is a small molecule BDNF mimetic displaying neurotrophhic activity. Partial agonist at TRKB and activates TRKB signaling. In in vitro models of neurodegenerative disease, it prevented neuronal degeneration with equal efficacy to that of BDNF. After in vivo administraton, LM22A-4 caused hippocampal and striatal TrkB activation in mice and improved motor learning after traumatic brain injury in rats.1?Improves respiratory function in a mouse models of Rett syndrome.2
Uses
LM 22A4 is a potent tropomyosin-related kinase B (TrkB) agonist. LM 22A4 has been show to induce activation of Trk, Akt and ERK in mouse hippocampus and striatum and reverse deficits in motor task learning in mice following traumatic brain injury. LM 22A4 also restored respiratory function in a rat model of Rett syndrome.
storage
Store at +4°C
References
1) Massa et al. (2010), Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents; J. Clin. Invest., 120 1774 2) Schmid et al. (2012), A TrkB small molecule partial agonist rescues TrkB phosphorylation deficits and improves respiratory function in a mouse model of Rett syndrome; J. Neurosci., 32 1803
LM 22A4 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178 +86-85511178 | peter68@ptchemgroup.com | China | 35453 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 50000 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94838 | 76 |
| Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8073 | 58 |
| Shanghai Leto Pharmatech Co.,Ltd. | 18016401466 | sales@letopharm.com | China | 219 | 58 |
| HangZhou YuHao Chemical Technology Co., Ltd. | 0571-82693216 | info@yuhaochemical.com | China | 2031 | 58 |