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MG-132

MG-132 structure

CAS No.: 133407-82-6

Chemical Name:: MG-132

Synonyms: CS-216;MG-132;Z-LL-CHO;Z-LLL-al;Z-LLL-CHO;(S)-MG132;MG-132(SSS);MG132/MG-132;MG-132, >=98%;Z-LEU-LEU-LEU-H

CBNumber:: CB3298042

Molecular Formula:: C26H41N3O5

Molecular Weight:: 475.62

MDL Number:: MFCD00674886

MOL File:: 133407-82-6.mol

MSDS File:: SDS

Last updated:2023-06-30 15:45:59

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MG-132 Properties

Melting point	80-84℃ (DEC.)
alpha	-61～-67°
Boiling point	682.0±55.0 °C(Predicted)
Density	1.073
Flash point	366℃
storage temp.	-20°C
solubility	methanol: 1 mg/mL
form	solid film
pka	11.14±0.46(Predicted)
color	White
Water Solubility	Soluble in ethanol, chloroform, methanol, water.
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO, DMF or ethanol may be stored at -20° for up to 1 week.
InChIKey	TZYWCYJVHRLUCT-VABKMULXSA-N
FDA UNII	RF1P63GW3K

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P271-P280
Risk Statements	36/37/38
Safety Statements	24/25
WGK Germany	3
HS Code	29242990

MG-132 price More Price(58)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	474790	MG-132 A cell-permeable, potent, reversible proteasome inhibitor (K	133407-82-6	1mg	$56.2	2024-03-01	Buy
Sigma-Aldrich	474787	MG-132, ≥95% by HPLC	133407-82-6	10mg	$85.2	2024-03-01	Buy
Alfa Aesar	J63250	MG 132	133407-82-6	1mg	$35.4	2023-06-20	Buy
Alfa Aesar	J63250	MG 132	133407-82-6	5mg	$134	2023-06-20	Buy
Cayman Chemical	10012628	(S)-MG132 ≥98%	133407-82-6	1mg	$20	2024-03-01	Buy

Product number	Packaging	Price	Buy
474790	1mg	$56.2	Buy
474787	10mg	$85.2	Buy
J63250	1mg	$35.4	Buy
J63250	5mg	$134	Buy
10012628	1mg	$20	Buy

MG-132 Chemical Properties,Uses,Production

Description

MG-132 (133407-82-6) is a specific inhibitor of the chymotrypsin-like activity of the 20S proteasome (IC50=100 nM with Z-LLL-AMC as substrate).1 Also inhibits calpain (IC50=1.25 μM).1 Suppresses gastric cancer cell proliferation and induces macro-autophagy.2 Activates stress kinases and induces Hsp72.3 Induces neurite outgrowth.1 MG-132 blocks NFκB activation by blocking IκB proteolysis (IC50=3 μM).4 Cell permeable.

Uses

MG 132 is a potent, membrane-permeable proteasome inhibitor. It induces neurite outgrowth in PC12 cells. Neuroprotective product.

Uses

A proteasome and NF-κB inhibitor.

Definition

ChEBI: A tripeptide that is L-leucyl-L-leucyl-L-leucine in which the C-terminal carboxy group has been reduced to the corresponding aldehyde and the N-terminal amino group is protected as its benzyloxycarbonyl derivative.

General Description

Potent, reversible, and cell-permeable proteasome inhibitor (K_i = 4 nM). Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1) and inhibits NF-κB activation (IC₅₀ = 3 μM).

Biological Activity

Potent cell-permeable inhibitor of proteasome (IC 50 = 100 nM) and calpain (IC 50 = 1.2 μ M). Inhibits TNF- α -induced NF- κ B activation and I κ B α degradation. Induces neurite outgrowth in PC12 cells and has anticancer properties in vitro .

Biochem/physiol Actions

Cell permeable: yes

storage

-20°C (desiccate)

References

1) Tsubuki et al. (1996), Differential inhibition of calpain and proteasome activities by peptidyl aldehydes of di-leucine and tri-leucine; J. Biochem.,? 119 572 2) Wu? et al. (2010), Macroautophagy and ERK phosphorylation counteract the antiproliferative effect of proteasome inhibitor in gastric cancer cells; Autophagy, 6 228 3) Meriin? et al. (1998), Proteasome inhibitors activate stress kinases and induce Hsp72. Diverse effects on apoptosis; J. Biol. Chem., 273 6373 4) Fiedler et al. (1998), Inhibition of TNF-alpha-induced NF-kappaB activation and IL-8 release in A549 cells with the proteasome inhibitor MG-132; Am. J. Respir. Cell Mol. Biol., 19 259

MG-132 Preparation Products And Raw materials

Raw materials

Preparation Products

MG-132 Suppliers

Global( 290)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Alpha Biopharmaceuticals Co., Ltd	+86-411-39042497 +8613921981412	sales@alphabiopharm.com	China	886	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	967	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10248	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5993	58

Supplier	Advantage
Alpha Biopharmaceuticals Co., Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
Biochempartner	58
Shenzhen Nexconn Pharmatechs Ltd	58
Hubei Jusheng Technology Co.,Ltd.	58
BOC Sciences	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Hebei Yanxi Chemical Co., Ltd.	58

View Lastest Price from MG-132 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-12-20	MG-132 133407-82-6	US $1.00 / g	1g	99.99%	2tons	Career Henan Chemical Co

MG-132
133407-82-6
US $1.00 / g
99.99%
Career Henan Chemical Co

MG-132 Spectrum

MG-132(133407-82-6)¹HNMR

133407-82-6(MG-132)Related Search:

MG-115 Z-Leu-Leu-Beta-Hotyr-al ACHROMOPEPTIDASE Trypsin trysin-chymotrypsin

Basic protease CALPAIN INHIBITOR I MG-132 Calpain Inhibitor I LACTACYSTIN

L-Leu-Leu-Leu Z-LLL-AMC Z-LEU-LEU-LEU-FMK MG-262 CALPAIN INHIBITOR IV

MG-132 in Solution 1 MG PROTEASOME INHIBITOR MG-132Z-LEU-LEU-LEU-H (ALDEHYDE) 5 MG PROTEASOME INHIBITOR MG-132Z-LEU-LEU-LEU-H (ALDEHYDE)

1of4

PROTEASOME INHIBITOR MG-132 N-[(PHENYLMETHOXY)CARBONYL]-L-LEUCYL-N-[(1S)-1-FORMYL-3-METHYLBUTYL]-L-LEUCINAMIDE N-CBZ-LEU-LEU-LEUCINAL Z-LLL-CHO Z-LL-CHO Z-LEU-LEU-LEU-CHO Z-LEU-LEU-LEU-H Z-LEU-LEU-LEU-H (ALDEHYDE) Z-LEU-LEU-LEU-ALDEHYDE Z-LEU-LEU-ALDEHYDE N-cbz-leu-leu-leu-al z-leu-leu-leu-al CALPAIN INHIBITOR IV CARBOBENZOXY-L-LEUCYL-L-LEUCYL-LEUCINAL CARBOBENZOXY-L-LEUCYL-L-LEUCYL-L-LEUCINAL BENZYLOXYCARBONYL-L-LEUCYL-L-LEUCYL-L-LEUCINAL benzyloxycarbonylleucyl-leucyl-leucinealdehyde (S)-MG132 N-carbobenzyloxy-Leu-Leu-Leu-al MG-132;Z-LEU-LEU-LEU-AL Z-Leu-Leu-Leu-al,MG132 Calpain inhibitor IV-2 L-LeucinaMide, N-[(phenylMethoxy)carbonyl]-L-leucyl-N-[(1S)-1-forMyl-3-Methylbutyl]- MG132/MG-132 MG-132 [Z-Leu-Leu-Leu-CHO] Z-LEU-LEU-LEU-AL, >=90% (HPLC) Benzyl (S)-4-methyl-1-((S)-4-methyl-1-((S)-4-methyl-1-oxopentan-2-ylamino)-1-oxopentan-2-ylami InSolution? MG-132 MG-132, ≥95% by HPLC N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal benzyl ((S)-4-Methyl-1-(((S)-4-Methyl-1-(((S)-4-Methyl-1-oxopentan-2-yl)aMino)-1-oxopentan-2-yl)aMino)-1-oxopentan-2-yl)carbaMate MG 132 Calpain inhibitor IV-2 N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-L-leucinamide Calpain inhibitor IV-2 MG 132 MG-132, >=98% MG 132;MG132;Z-LEU-LEU-LEU-CHO;CARBOBENZOXY-L-LEUCYL-L-LEUCYL-L-LEUCINAL MG132, 98%, proteasome inhibitor CS-216 MG-132 - CAS 133407-82-6 - Calbiochem MG-132, ≥95% by HPLC - CAS 133407-82-6 - Calbiochem InSolution MG-132 - CAS 133407-82-6 - Calbiochem benzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate Z-LLL-al 133407-82-6 MG-132 C26H41N3O5 MG-132 MG-132,Inhibitor,MG132,MG 132,complex,peptide,calpain,Autophagy,proteolytic,Proteasome,aldehyde,inhibit,Apoptosis,26S MG-132 solution (10mM/L) MG-132(SSS) MG-132 (Ethanol Solution) 133407-82-6 C26H41N3O5 Cell Signaling Enzymes BioChemical Biochemicals and Reagents Application Index Enzymes, Inhibitors, and Substrates Proteasome, Calpain and Lysosomal Proteases Proteasomes Inhibitors