3-(3-(Trifluoromethyl)phenyl)propanal
- CAS No.
- 21172-41-8
- Chemical Name:
- 3-(3-(Trifluoromethyl)phenyl)propanal
- Synonyms
- 3-(3-TRIFLUOROMETHYL-PHENYL)-PROPIONALDEHYDE;3-(3-(trifluoroMethyl)phenyl)propanal;Cinacalcet Impurity 54;3-(Trifluoromethyl)benzenepropanal;4-[3-(trifluoroMethyl)phenyl]butanal;Benzenepropanal, 3-(trifluoroMethyl)-;m-(Trifluoromethyl)hydrocinnamaldehyde;3-(trifluoroMethylphenyl)propionaldehyde;3-(3-TRIFLUOROMETHYL-PHENYL)-PROPIOLDEHYDE;3-(3’-TRIFLUOROMETHYL PHENYL)PROPIONALDEHYDE
- CBNumber:
- CB3420003
- Molecular Formula:
- C10H9F3O
- Molecular Weight:
- 202.17
- MDL Number:
- MFCD07772918
- MOL File:
- 21172-41-8.mol
- MSDS File:
- SDS
| Boiling point | 207.4±35.0 °C(Predicted) |
|---|---|
| Density | 1.192±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | Soluble in Chloroform, Dichloromethane, Ethyl acetate |
| form | Oil |
| color | Clear colorless to pale yellow oily liquid |
| Stability | Not very stable, new spot on TLC if kept at r.t. o/n. |
| InChI | InChI=1S/C10H9F3O/c11-10(12,13)9-5-1-3-8(7-9)4-2-6-14/h1,3,5-7H,2,4H2 |
| InChIKey | APCCHYPQHODSBD-UHFFFAOYSA-N |
| SMILES | C1(CCC=O)=CC=CC(C(F)(F)F)=C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+332-H315-H319-H335 |
| Precautionary statements | P260-P280 |
| HS Code | 2912490090 |
3-(3-(Trifluoromethyl)phenyl)propanal price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-T791100-250MG | 3-(Trifluoromethyl)benzenepropanal | 21172-41-8 | 250mg | $212 | 2026-06-03 | Buy |
| Apolloscientific | PC57040 | 3-[3-(Trifluoromethyl)phenyl]propanal 98% | 21172-41-8 | 100mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC57040 | 3-[3-(Trifluoromethyl)phenyl]propanal 98% | 21172-41-8 | 250mg | $22 | 2026-06-04 | Buy |
| Apolloscientific | PC57040 | 3-[3-(Trifluoromethyl)phenyl]propanal 98% | 21172-41-8 | 1g | $26 | 2026-06-04 | Buy |
| Apolloscientific | PC57040 | 3-[3-(Trifluoromethyl)phenyl]propanal 98% | 21172-41-8 | 5g | $64 | 2026-06-04 | Buy |
3-(3-(Trifluoromethyl)phenyl)propanal Chemical Properties, Uses, Production
Uses
3-(Trifluoromethyl)benzenepropanal is a compound useful in organic synthesis.
Description
3-(3-(Trifluoromethyl)phenyl)propanal is a bis-functional compound containing trifluoromethyl and aldehyde groups, which also serves as a key intermediate in the synthesis of Cinacalcet Hydrochloride. In addition, 3-(3-(Trifluoromethyl)phenyl)propanal can be used in the preparation of fluorinated fine chemicals and polymeric materials.
Chemical Properties
Colourless Oil
Uses
3-(Trifluoromethyl)benzenepropanal (cas# 21172-41-8) is a compound useful in organic synthesis.
Synthesis
A solution of 3-(Trifluoromethyl) benzene propanol (1.0 g, 4.90 mmol) in dichloromethane (20 ml) is cooled in a water/ice bath, treated in succession with DMSO (770 mg, 9.80 mmol) and P2O5 (1.39 g, 9.80 mmol) and left under stirring for 30 minutes, while temperature raises to 20°C. The reaction mixture is then cooled in water/ice bath and triethylamine (2.4 ml, 17.15 mmol). The resulting solution is kept under stirring while the temperature raises to 20°C. After one hour, the mixture is treated with 5 per cent HCl, the phases are separated, and the organic one is further washed with 5 per cent HCl. The organic phase is then washed with brine, dried over Na2SO4, filtered and concentrated under reduced pressure to afford 0.99 g of the aldehyde of 3-(3-(Trifluoromethyl)phenyl)propanal in quantitative yield.
References
[1] Patent: EP2327684, 2011, A1. Location in patent: Page/Page column 6
[2] Patent: US2011/124917, 2011, A1. Location in patent: Page/Page column 3-4
[3] Journal of the Indian Chemical Society, 2013, vol. 90, # 8, p. 1259 - 1261
[4] Patent: WO2014/16847, 2014, A1. Location in patent: Page/Page column 6-7
[5] Tetrahedron Letters, 2004, vol. 45, # 45, p. 8355 - 8358
3-(3-(Trifluoromethyl)phenyl)propanal Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Energy Chemical | 400-0056266 18918157536; | sales8178@energy-chemical.com | China | 45000 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Scientia Pharmaceutical Technology Co., Ltd. | 21-21-54301573 13917723525 | sales@scientiapharm.com | China | 260 | 62 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Adamas Reagent, Ltd. | 4006009262 13023226327 | hmj@titansci.com | China | 14098 | 59 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16307 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
View Latest Price from 3-(3-(Trifluoromethyl)phenyl)propanal manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 3-(3-TRIFLUOROMETHYL-PHENYL)-PROPIONALDEHYDE
21172-41-8
|
$5.00 | 1KG | 98% | Henan Fengda Chemical Co., Ltd | ||
 |
2025-04-04 | 3-(3-TRIFLUOROMETHYL-PHENYL)-PROPIONALDEHYDE
21172-41-8
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2023-08-29 | 3-(3-TRIFLUOROMETHYL-PHENYL)-PROPIONALDEHYDE
21172-41-8
|
$30.00 | 1kg | 99% | 1000tons | Henan Bao Enluo International TradeCo.，LTD |
-
- 3-(3-TRIFLUOROMETHYL-PHENYL)-PROPIONALDEHYDE
21172-41-8
- $5.00
- 98%
- Henan Fengda Chemical Co., Ltd
-
- 3-(3-TRIFLUOROMETHYL-PHENYL)-PROPIONALDEHYDE
21172-41-8
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 3-(3-TRIFLUOROMETHYL-PHENYL)-PROPIONALDEHYDE
21172-41-8
- $30.00
- 99%
- Henan Bao Enluo International TradeCo.，LTD
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