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4-(2-Chloroethyl)morpholine

4-(2-Chloroethyl)morpholine Structure
4-(2-Chloroethyl)morpholine structure
CAS No.
3240-94-6
Chemical Name:
4-(2-Chloroethyl)morpholine
Synonyms
N-CHLOROETHYLMORPHOLINE;tl401;TIMTEC-BB SBB004079;morpholinoethylchloride;2-morpholinoethylchloride;beta-chloroethylmorpholine;4-(2-chloroethyl)-morpholin;1-(2-Chloroethyl)Morpholine;N-(2-Chloroethyl)-morpholine;beta-morpholinoethylchloride
CBNumber:
CB3672853
Molecular Formula:
C6H12ClNO
Molecular Weight:
149.62
MDL Number:
MFCD00603731
MOL File:
3240-94-6.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:50
Product description Number Pack Size Price
4-(2-Chloroethyl)morpholine >98.0%(GC)(T) C3061 5g $122
4-(2-Chloroethyl)morpholine C363290 500mg $45
4-(2-Chloroethyl)morpholine C363290 1g $55
4-(2-Chloroethyl)morpholine 98% OR903887 5g $80
4-(2-Chloroethyl)morpholine FC139778 5G $80
More product size
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4-(2-Chloroethyl)morpholine Properties

Boiling point 94°C/12mmHg(lit.)
Density 1.0823 (rough estimate)
refractive index 1.4750 to 1.4790
storage temp. Storage temp. -20°C
pka 6.15±0.10(Predicted)
Appearance Colorless to light yellow Liquid
InChI InChI=1S/C6H12ClNO/c7-1-2-8-3-5-9-6-4-8/h1-6H2
InChIKey ZAPMTSHEXFEPSD-UHFFFAOYSA-N
SMILES N1(CCCl)CCOCC1
CAS DataBase Reference 3240-94-6(CAS DataBase Reference)
EPA Substance Registry System Morpholine, 4-(2-chloroethyl)- (3240-94-6)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS05,GHS06
Signal word  Danger
Hazard statements  H227-H301-H314-H412
Precautionary statements  P210-P273-P280-P301+P310-P305+P351+P338-P310
RIDADR  UN 2922 8/6.1/PG III
RTECS  QE0175000
HazardClass  8/6.1
PackingGroup  III
HS Code  2934999090

4-(2-Chloroethyl)morpholine price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical C3061 4-(2-Chloroethyl)morpholine >98.0%(GC)(T) 3240-94-6 5g $122 2021-12-16 Buy
TRC C363290 4-(2-Chloroethyl)morpholine 3240-94-6 500mg $45 2021-12-16 Buy
TRC C363290 4-(2-Chloroethyl)morpholine 3240-94-6 1g $55 2021-12-16 Buy
Apolloscientific OR903887 4-(2-Chloroethyl)morpholine 98% 3240-94-6 5g $80 2021-12-16 Buy
Biosynth Carbosynth FC139778 4-(2-Chloroethyl)morpholine 3240-94-6 5G $80 2021-12-16 Buy
Product number Packaging Price Buy
C3061 5g $122 Buy
C363290 500mg $45 Buy
C363290 1g $55 Buy
OR903887 5g $80 Buy
FC139778 5G $80 Buy

4-(2-Chloroethyl)morpholine Chemical Properties,Uses,Production

Uses

4-(2-Chloroethyl)morpholine

Synthesis

2-Morpholinoethanol

622-40-2

4-(2-Chloroethyl)morpholine

3240-94-6

Thionyl chloride (69.44 mmol, 5.06 mL, 5.0 eq.) was slowly added to a stirred solution of 2-morpholinoethan-1-ol (13.88 mmol, 2.5 g, 1.0 eq.) in dichloromethane (25 mL) with a catalytic amount of DMF at 0 °C. The reaction mixture was heated to 40 °C overnight. The reaction progress was monitored by TLC. After completion of the reaction, the solvent was removed by vacuum evaporation to give the crude product. The crude product was diluted with dichloromethane and washed with saturated sodium bicarbonate solution. The organic layer was concentrated under reduced pressure to give the crude residue. The crude product was purified by column chromatography using dichloromethane solution containing 3% methanol as eluent to afford the target compound 4-(2-chloroethyl)morpholine (2.0 g, 74.0% yield) as a colorless liquid.1H NMR (DMSO-d6, 300 MHz): δ 3.69 (t, J = 6.9 Hz, 2H), 3.57 (m, J = 4.5 Hz, 4H ), 2.64 (t, J = 6.9 Hz, 2H), 2.43 (t, J = 4.5 Hz, 4H); MS: [M + H]+ 149.95 (10%).

References

[1] Patent: WO2017/149518, 2017, A1. Location in patent: Page/Page column 25; 26
[2] Patent: WO2018/29604, 2018, A1. Location in patent: Page/Page column 47
[3] Journal of the American Chemical Society, 1940, vol. 62, p. 1443,1446
[4] Journal of the American Pharmaceutical Association (1912-1977), 1953, vol. 42, p. 342
[5] Journal of the Indian Chemical Society, 1959, vol. 36, p. 349,352

4-(2-Chloroethyl)morpholine synthesis

622-40-2
3240-94-6
Synthesis of 4-(2-Chloroethyl)morpholine from 2-Morpholinoethanol

4-(2-Chloroethyl)morpholine Preparation Products And Raw materials

Raw materials

4,4'-(ethane-1,2-diyl)bismorpholine N-CHLOROMETHYLMORPHOLINE Chloroacetaldehyde 2-Bromoethanol 1-Bromo-2-chloroethane
4-(2-Chloroethyl)morpholine hydrochloride 2-Morpholinoethanol N,N-Dimethylformamide 1,2-Dichloroethane Morpholine

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Preparation Products

2-(2-MORPHOLIN-4-YLETHOXY)ANILINE morpheridine Ethyl 1-(2-Morpholinoethyl)-1H-Pyrazole-4-Carboxylate 4-Morpholineethanamine, N-[3-(trifluoromethyl)phenyl]- 1-(2-Morpholinoethyl)-1H-pyrazol-4-amine
4-Morpholineethanamine, N-2-pyridinyl-

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4-(2-Chloroethyl)morpholine Suppliers

Global( 150)Suppliers
Supplier Tel Email Country ProdList Advantage
Shaanxi Dideu Medichem Co. Ltd 		+86-029-81138252 +86-173 9270 1263 1057@dideu.com China 3999 58
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
Jinan Carbotang Biotech Co.,Ltd. 		+8615866703830 figo.gao@foxmail.com China 8497 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49975 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29798 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051 joe@yuhengpharm.com CHINA 21142 58
Zhengzhou Alfa Chemical Co.,Ltd 		+8618530059196 sale04@alfachem.cn China 11819 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58
Shanghai UCHEM Inc. 		+862156762820 +86-13564624040 sales@myuchem.com China 8460 58
Supplier Advantage
Shaanxi Dideu Medichem Co. Ltd 		58
ATK CHEMICAL COMPANY LIMITED 		60
Jinan Carbotang Biotech Co.,Ltd. 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		58
Zhengzhou Alfa Chemical Co.,Ltd 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
Shanghai UCHEM Inc. 		58

View Lastest Price from 4-(2-Chloroethyl)morpholine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-(2-Chloroethyl)morpholine pictures 2024-07-11 4-(2-Chloroethyl)morpholine
3240-94-6
 US $1.00 / KG 1KG 98% 20T Shaanxi Dideu Medichem Co. Ltd
4-(2-Chloroethyl)morpholine pictures 2020-01-09 4-(2-Chloroethyl)morpholine
3240-94-6
 US $2.00 / KG 1KG 98% 1kg, 5kg ,50kg Career Henan Chemical Co

4-(2-Chloroethyl)morpholine Spectrum

4-(2-Chloroethyl)morpholine(3240-94-6)1HNMR

3240-94-6(4-(2-Chloroethyl)morpholine)Related Search:

N-(2,2-DICHLORO-1-MORPHOLINOETHYLIDENE)-N'-[2-(2,4-DICHLOROPHENOXY)PHENYL]UREA 4-[CHLORO(PHENYL)ACETYL]MORPHOLINE 4-(2-CHLOROACETYL)MORPHOLINE TRIMORPHAMID 4-(2-Chloroethyl)morpholine hydrochloride
4-(2-chloropropanoyl)-2-methylmorpholine TIMTEC-BB SBB010861 4-(CHLOROACETYL)-2-METHYLMORPHOLINE 4-(8,8-DICHLORO-4,6,6-TRIMETHYL-3-OXATRICYCLO[5.1.0.0(2,4)]OCT-1-YL)MORPHOLINE N-(2,2-DICHLORO-1-MORPHOLINOETHYLIDENE)-N'-(5-METHYLISOXAZOL-3-YL)UREA
4-[2-CHLORO-2-(PHENYLSULFONYL)ETHYL]-1,4-OXAZINAN-4-IUM CHLORIDE 3(2H)-Pyridazinone, 6-chloro-5-(4-morpholinyl)-, hydrazone, sulfate (1 :1) 4-(2-Chloroethyl)morpholine

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TIMTEC-BB SBB004079 4-(2-CHLORO-ETHYL)-MORPHOLINE 2-(4-morpholinyl)ethylchloride 2-morpholinoethylchloride 4-(2-chloroethyl)-morpholin beta-chloroethylmorpholine beta-morpholinoethylchloride morpholinoethylchloride tl401 1-(2-Chloroethyl)Morpholine N-(2-Chloroethyl)-morpholine 4-(2-CHLOROETHYL) MORPHOLINE HYDROCHLORI DE(OTHER CMPNDS CNTNG AN UNFUSED PYRDN R ING(W/N HYDRGNTD)IN STRUCTURE)(DRUG INTE Morpholine,4-(2-chloroethyl)- N-CHLOROETHYLMORPHOLINE Galactose Impurity 3 (Galactose EP Impurity C) 3240-94-6 Thiadiazoles