CALPAIN INHIBITOR III
- CAS No.
- 88191-84-8
- Chemical Name:
- CALPAIN INHIBITOR III
- Synonyms
- CS-1705;Calp III;MDL 28170;Z-Val-Phe-H;Z-VAL-PHE-CHO;4R)-Tofacitinib;Z-L-Val-L-Phe-OH;Z-VAL-PHE-ALDEHYDE;Cbz-L-Val-L-Phe-OH;CALPAIN INHIBITOR III
- CBNumber:
- CB3723465
- Molecular Formula:
- C22H26N2O4
- Molecular Weight:
- 382.45
- MDL Number:
- MFCD00798796
- MOL File:
- 88191-84-8.mol
- MSDS File:
- SDS
| Boiling point | 595.6±50.0 °C(Predicted) |
|---|---|
| Density | 1.153±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: 26 mg/mL |
| form | White lyophilized solid |
| pka | 11.05±0.46(Predicted) |
| color | White |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| FDA UNII | WCJ9LQ197S |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332-H315-H319-H335 |
| Precautionary statements | P260-P280-P301+P312 |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| HS Code | 2924297099 |
CALPAIN INHIBITOR III price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | M6690 | MDL 28170 ≥95% (HPLC) | 88191-84-8 | 25mg | $260 | 2024-03-01 | Buy |
| Sigma-Aldrich | 208722 | Calpain Inhibitor III - CAS 88191-84-8 - Calbiochem | 88191-84-8 | 25MG | $216 | 2024-03-01 | Buy |
| Alfa Aesar | J62919 | Calpain Inhibitor III, 95+% | 88191-84-8 | 25mg | $139 | 2023-06-20 | Buy |
| Cayman Chemical | 14283 | Calpain Inhibitor III ≥95% | 88191-84-8 | 5mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 14283 | Calpain Inhibitor III ≥95% | 88191-84-8 | 10mg | $61 | 2024-03-01 | Buy |
CALPAIN INHIBITOR III Chemical Properties,Uses,Production
Description
MDL-28170 (88191-84-8) is a potent and selective cell permeable calpain inhibitor. Inhibits oxidative damage-induced apoptosis in PC12 cells and capsaicin-induced apoptosis in dorsal root ganglion neurons.1?It penetrates the blood-brain barrier and inhibits brain cysteine protease activity after systemic administration, ameliorating brain damage in a gerbil model of global ischemia.2?Displays neuroprotective effects in neurotrauma rodent models.3?Calpain I Ki?= 8 nM; Cathepsin B Ki?= 24 nM in isolated enzyme assays. IC50?= 0.3 μM in intact cell assay.4
Uses
Inhibits calpain proteolysis
Uses
MDL 28170 acts as a caplain inhibitor reducing hypoxia in ischemic-retinopathy, and various other neuroprotective effects.
Definition
ChEBI: A dipeptide resulting from the formal condensation of the carboxy group of N-benzyloxycarbonyl-L-valine with the amino group of L-phenylalanine aldehyde. It is a potent cell-permeable inhibitor of calpai I and II, and is also a gamma-secretase inhibitor.
General Description
A potent, cell-permeable inhibitor of calpain I and II (Ki = 8 nM) that also reduces capsaicin-mediated cell death in cultured dorsal root ganglion. Reported to block A23187-induced suppression of neurite outgrowth in isolated hippocampal pyramidal neurons. Exhibits neuroprotective effects against glutamate-induced toxicity.
Biological Activity
Potent, selective inhibitor of calpain and cathepsin B (K i values are 10 and 25 nM respectively) that does not inhibit trypsin-like serine proteases. Rapidly penetrates the blood-brain barrier following systemic administration and displays neuroprotective effects in vivo .
Biochem/physiol Actions
Cell permeable: yes
References
1) Chard?et al.?(1995),?Capsaicin-induced neurotoxicity in cultured dorsal root ganglion neurons: involvement of calcium-activated proteases; Neuroscience,?65?1099 2) Li?et al.?(1998),?Postischemic treatment with calpain inhibitor MDL28170 ameliorates brain damage in a gerbil model of global ischemia; Neurosci. Lett.,?247?17 3) Thompson?et al. (2010),?A pharmacological analysis of the neuroprotective efficacy of the brain- and cell-permeable calpain inhibitor MDL-28170 in the mouse controlled cortical impact traumatic brain injury model; J. Neurotrauma,?27?2233 4) Chatterjee?et al.?(1998),?D-amino acid containing, high-affinity inhibitors of recombinant human calpain I; J. Med. Chem.,?41?2663
CALPAIN INHIBITOR III Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alpha Biopharmaceuticals Co., Ltd | +86-411-39042497 +8613921981412 | sales@alphabiopharm.com | China | 886 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10326 | 58 |
| HONG KONG IPURE BIOLOGY CO.,LIMITED | 86 18062405514 18062405514 | ada@ipurechemical.com | CHINA | 3465 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23556 | 58 |
| BOC Sciences | +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19915 | 58 |
View Lastest Price from CALPAIN INHIBITOR III manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-02-19 | CALPAIN INHIBITOR III
88191-84-8
|
US $7.00 / KG | 1KG | 99% | 100kg | Career Henan Chemical Co |
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- CALPAIN INHIBITOR III
88191-84-8
- US $7.00 / KG
- 99%
- Career Henan Chemical Co