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NOBILETIN

Description Source Uses structure and hydrogen bonding Application
NOBILETIN
NOBILETIN structure
CAS No.
478-01-3
Chemical Name:
NOBILETIN
Synonyms
biletin;NOBILETIN;Nobiletin>Nobiletin, >=98%;Chuanpi glycosides;hexamethoxyflavone;Nobiletin 478-01-3;NOBILETIN WITH HPLC;5,6,7,8-tetramethoxy-;Nobiletin,Hexamethoxyflavone
CBNumber:
CB3740677
Molecular Formula:
C21H22O8
Formula Weight:
402.39
MOL File:
478-01-3.mol

NOBILETIN Properties

Melting point:
136.0 to 140.0 °C
Boiling point:
587.9±50.0 °C(Predicted)
Density 
1.244±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
form 
neat
BRN 
360887
InChIKey
MRIAQLRQZPPODS-UHFFFAOYSA-N
CAS DataBase Reference
478-01-3(CAS DataBase Reference)
EWG's Food Scores
1
FDA UNII
D65ILJ7WLY
SAFETY
  • Risk and Safety Statements
Safety Statements  24/25
WGK Germany  3
RTECS  DJ3052200
HS Code  29329990

NOBILETIN price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich N1538 Nobiletin ≥97% 478-01-3 5mg $265 2019-12-02 Buy
Sigma-Aldrich N1538 Nobiletin ≥97% 478-01-3 10mg $665 2019-12-02 Buy
TCI Chemical N0871 Nobiletin >95.0%(HPLC) 478-01-3 10mg $130 2021-03-22 Buy
TCI Chemical N0871 Nobiletin >95.0%(HPLC) 478-01-3 100mg $715 2021-03-22 Buy
Cayman Chemical 15421 Nobiletin ≥98% 478-01-3 5mg $35 2021-03-22 Buy

NOBILETIN Chemical Properties,Uses,Production

Description

Nobiletin (NOB) chemically known as 5,6,7,8,3′,4′-hexamethoxyflavone is a dietary polymethoxylated flavonoid found in Citrus fruits. Nobiletin is a flavonoid isolated from citrus peels. It is an O-methylated flavone that has the activity to rescue bulbectomy-induced memory impairment.

Source

Nobiletin is a nonpolar polymethoxylated flavone (PMFs) found in the citrus peel of various fruits, such as tangerine. Its chemical structure is similar to tangeretin, containing the typical flavonoid structure and six methoxyl groups (one more than tangeretin).

Uses

NOB is a multifunctional pharmaceutical agent. The various pharmacological activities of NOB include neuroprotection, cardiovascular protection, antimetabolic disorder, anticancer, anti-inflammation, and antioxidation.

structure and hydrogen bonding

The crystal structure study on NOB shows that the chromene and the arene rings are almost in the same plane. The C atoms of the two methoxy groups in the arene ring are also in the same plane, while the C atoms of four methoxy groups linking to the chromene ring are not in parallel. This conformational characteristic of chiral structure is indicated by the covalent bond rotation between the arene and the chromene rings and the conformational alternations of methoxy groups.

Application

Nobiletin has been shown to exhibit antioxidant, anti-inflammatory, antitumor/cancer, and antiangiogenic activity in vitro and in vivo. Animal and in vitro data also demonstrate nobiletin's potential ability to suppress bone loss, lower cholesterol and atherosclerosis, and improve hyperglycemia and insulin resistance.

Chemical Properties

White powder

Uses

matrix metaloproteinase inhibitor; antineoplastic

Definition

ChEBI: A methoxyflavone that is flavone substituted by methoxy groups at positions 5, 6, 7, 8, 3' and 4' respectively.

NOBILETIN Preparation Products And Raw materials

Raw materials

Preparation Products


NOBILETIN Suppliers

Global( 255)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8882 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29961 58
Chengdu Biopurify Phytochemicals Ltd.
18482058008 18080483897
maggie@biopurify.com CHINA 2712 58
Nanjing Dolon Biotechnology Co.,Ltd.
18905173768
sales@dolonchem.com CHINA 2972 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Shaanxi Pioneer Biotech Co., Ltd .
86-13259417953(Whatsapp/Wechat) 86-13259417953(Whatsapp)
029-84385017 sales@pioneerbiotech.com CHINA 3001 58
NanJing Spring & Autumn Biological Engineering CO., LTD.
0086 13815430202 0086 13815430202
sale02@cqherb.com CHINA 372 58
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19753 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58

View Lastest Price from NOBILETIN manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-09-26 Nobiletin 478-01-3
478-01-3
US $44.50 / g 10mg ≥98% 100.00 kgs NanJing Spring & Autumn Biological Engineering CO., LTD.
2021-07-30 nobiletin
478-01-3
US $44.00 / g 1g 98% 10kg Nanjing Sky Hope Tongyuan Biological Engineering Co., Ltd.
2021-07-29 NOBILETIN
478-01-3
US $10.00 / KG 1KG 99.9% 100MT/Month Wuhan wingroup Pharmaceutical Co., Ltd

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