Hexamidine
- CAS No.
- 3811-75-4
- Chemical Name:
- Hexamidine
- Synonyms
- Hexamidine;Hexamidine【antipeptic】;Hexcarbacholine bromide;4-[6-(4-amidinophenoxy)hexoxy]benzamidine;4,4'-(Hexamethylenedioxy)bis(benzamidine);4,4'-(Hexamethylenebisoxy)bis(benzamidine);4,4'-(1,6-Hexanediyl)bis(oxy)bisbenzamidine;4,4'-[1,6-Hexanediylbis(oxy)]bisbenzamidine;4,4'-[1,6-Hexanediylbis(oxy)]bis[benzamidine];Benzenecarboximidamide, 4,4'-[1,6-hexanediylbis(oxy)]bis-
- CBNumber:
- CB3961315
- Molecular Formula:
- C20H26N4O2
- Molecular Weight:
- 354.45
- MDL Number:
- MOL File:
- 3811-75-4.mol
- MSDS File:
- SDS
| Boiling point | 548.6±60.0 °C(Predicted) |
|---|---|
| Density | 1.19±0.1 g/cm3(Predicted) |
| pka | 12.80±0.50(Predicted) |
| InChI | InChI=1S/C20H26N4O2/c21-19(22)15-5-9-17(10-6-15)25-13-3-1-2-4-14-26-18-11-7-16(8-12-18)20(23)24/h5-12H,1-4,13-14H2,(H3,21,22)(H3,23,24) |
| InChIKey | OQLKNTOKMBVBKV-UHFFFAOYSA-N |
| SMILES | C(OC1=CC=C(C(N)=N)C=C1)CCCCCOC1=CC=C(C(N)=N)C=C1 |
| LogP | 3.000 (est) |
| FDA UNII | 3483C2H13H |
Hexamidine Chemical Properties,Uses,Production
Description
Hexamidine (HEX) is a strong organic base and aromatic diamidine. Although hexamidine is primarily used as the diisethionate salt (HEX D), it was first synthesized as the dihydrochloride salt (HEX H) and patented for May & Baker Limited (U.K.) by Ewins et al. In the 1990s, the efficacy of HEX as an amoebicidal agent was demonstrated in several studies. In addition to biocidal activity, HEX, and other diamidines have demonstrated enzyme inhibition properties. Upregulation of the major cholesterol and fatty acid uptake pathways has also been demonstrated in a skin-equivalent tissue culture model following treatment with HEX[1].
Uses
hexamidine is generally used as a biocide and preservative. Some initial studies are indicating a potential to increase production of skin lipids, such as cholesterol, sphingolipids, and fatty acids. In turn this would help improve skin moisture content. Further evidence of this may be required.
Definition
ChEBI: A polyether that is the bis(4-guanidinophenyl) ether of hexane-1,6-diol.
Contact allergens
Hexamidine is an antiseptic active against Grampositive bacteria and fungi, used as a disinfectant and a preservative in cosmetics. It induces papulo-vesicular and diffuse allergic contact dermatitis.
References
[1] N. Parisi. “Hexamidine salts – applications in skin health and personal care products.” International Journal of Cosmetic Science 39 4 (2017): 361–365.
Hexamidine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9640 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29823 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| Alfa Chemistry | Info@alfa-chemistry.com | United States | 24072 | 58 | |
| Hebei Guanlang Biotechnology Co., Ltd. | +8619930503259 | cherry@crovellbio.com | China | 18421 | 58 |
| Zhengzhou Anbu Chem Co.,Ltd | +86-0371-88006763; +8615988602810 | sales@anbuchem.com | China | 3000 | 58 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
| T&W GROUP | 021-61551611 13296011611 | contact@trustwe.com | China | 9900 | 58 |
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 | waley188@sohu.com | China | 12338 | 58 |
View Lastest Price from Hexamidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-25 | HEXAMIDINE
3811-75-4
|
US $1.00 / KG | 1KG | 97%-99.9% | 100kg | Career Henan Chemical Co |
-
- HEXAMIDINE
3811-75-4
- US $1.00 / KG
- 97%-99.9%
- Career Henan Chemical Co