7-Azaindole-4-carboxaldehyde
- CAS No.
- 728034-12-6
- Chemical Name:
- 7-Azaindole-4-carboxaldehyde
- Synonyms
- 7-azaindole-4-carbaldehyde;7-azainole-4-carboxaldehyde;7-Azaindole-4-carbaldehyd...;7-Azaindole-4-carboxaldehyde;1H-Pyrrolo[2,3-b]pyridin-4-carbaldehyde;1H-pyrrolo[2,3-b]pyridine-4-carbaldehyde;1H-Pyrrolo[2,3-b]pyridine-4-carboxaldehyde;1H-Pyrrolo[2,3-b]pyridine-4-carboxaldehyde (9CI);1H-Pyrrolo[2,3-b]pyridine-4-carboxaldehyde (9CI, ACI)
- CBNumber:
- CB4100557
- Molecular Formula:
- C8H6N2O
- Molecular Weight:
- 146.15
- MDL Number:
- MFCD08272237
- MOL File:
- 728034-12-6.mol
- MSDS File:
- SDS
| Density | 1.368±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | 12.72±0.40(Predicted) |
| form | Solid |
| color | yellow |
| InChI | InChI=1S/C8H6N2O/c11-5-6-1-3-9-8-7(6)2-4-10-8/h1-5H,(H,9,10) |
| InChIKey | IEPOMBHPYZJZNR-UHFFFAOYSA-N |
| SMILES | C12NC=CC1=C(C=O)C=CN=2 |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H335-H319-H315 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 |
| WGK Germany | WGK 3 |
| HS Code | 2933998090 |
| Storage Class | 11 - Combustible Solids |
7-Azaindole-4-carboxaldehyde price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | CVT00121 | 7-Azaindole-4-carboxaldehyde AldrichCPR | 728034-12-6 | 1 g | $1100 | 2026-04-30 | Buy |
| Apolloscientific | OR471713 | 1H-Pyrrolo[2,3-b]pyridine-4-carbaldehyde 98% | 728034-12-6 | 100mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR471713 | 1H-Pyrrolo[2,3-b]pyridine-4-carbaldehyde 98% | 728034-12-6 | 250mg | $35 | 2026-06-04 | Buy |
| Apolloscientific | OR471713 | 1H-Pyrrolo[2,3-b]pyridine-4-carbaldehyde 98% | 728034-12-6 | 1g | $108 | 2026-06-04 | Buy |
| Apolloscientific | OR471713 | 1H-Pyrrolo[2,3-b]pyridine-4-carbaldehyde 98% | 728034-12-6 | 5g | $491 | 2026-06-04 | Buy |
7-Azaindole-4-carboxaldehyde Chemical Properties, Uses, Production
Uses
7-Azaindole-4-carboxaldehyde is used as a pharmaceutical intermediate.
Synthesis
344327-11-3
728034-12-6
General procedure for the synthesis of 7-azaindole-4-carboxaldehyde from 4-cyano-7-azaindole: Part 4: Preparation of 1H-pyrrolo[2,3-b]pyridine-4-carboxaldehyde: 1H-pyrrolo[2,3-b]pyridine-4-carbonitrile (200 mg, 1.4 mmol) was dissolved in tetrahydrofuran (7 mL) and cooled to -78°C under nitrogen protection. Diisobutylaluminum hydride (DIBAL-H, 1.0 M toluene solution, 3.07 mL, 3.07 mmol) was added slowly. The reaction mixture was stirred at -78 °C for 1 h. The temperature was gradually increased to 55 °C and stirring was continued for 2 h. The reaction mixture was then stirred at -78 °C for 1 h. Subsequently, DIBAL-H (1.4 mL, 1.4 mmol) was added supplementally and the mixture continued to stir at 55 °C for 2 hours. After completion of the reaction, the mixture was cooled to 5 °C, acidified with 2 M hydrochloric acid and stirred for 15 min. Next, the reaction mixture was neutralized with saturated aqueous sodium bicarbonate, the organic phase was extracted with dichloromethane (5 x 25 mL), the organic layers were combined and washed with brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give 1H-pyrrolo[2,3-b]pyridine-4-carbaldehyde (107 mg, 52% yield). Mass spectrum (ES+): m/z 146 [MH+]. 1H NMR (DMSO-d6, 400 MHz): δ 7.22 (d, 1H, J = 3.6 Hz), 7.57 (d, 1H, J = 4.8 Hz), 7.67 (d, 1H, J = 2.4 Hz), 8.61 (d, 1H, J = 5.2 Hz), 10.42 (s, 1H) .
References
[1] Patent: US2004/186124, 2004, A1. Location in patent: Page/Page column 14
[2] Patent: US2005/154014, 2005, A1
7-Azaindole-4-carboxaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zhenzhi Pharmaceutical Technology Co., Ltd | 15262370735 | 404840704@qq.com | China | 109 | 58 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16307 | 64 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
| Wuhan TCASChem Technology Co., Ltd. | 027-86697669 13986148687 | sales@tcaschem.com | China | 3999 | 55 |
| Candia Thamtech Company Limited | 0371-86615086 18203638366 0371-86159066 13526786601 | China | 2011 | 60 | |
| Shanghai Run-Biotech Co., Ltd. | 021-57171705 13817537615 | sales@run-biotech.com | China | 2270 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Hunan HuaTeng Pharmaceutical Co., Ltd., | 400-8592883 15367835770 | sales@huatengsci.com | China | 5869 | 58 |
View Latest Price from 7-Azaindole-4-carboxaldehyde manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-04-22 | 7-Azaindole-4-Carboxaldehyde
728034-12-6
|
98%min | 100kgs/month | Shanghai Rlavie Technology Co ltd | |||
 |
2019-07-12 | 7-AZAINDOLE-4-CARBOXALDEHYDE
728034-12-6
|
$1.00 | 1KG | 99% | 100kg | Career Henan Chemical Co |
-
- 7-Azaindole-4-Carboxaldehyde
728034-12-6
- 98%min
- Shanghai Rlavie Technology Co ltd
-
- 7-AZAINDOLE-4-CARBOXALDEHYDE
728034-12-6
- $1.00
- 99%
- Career Henan Chemical Co
