ChemicalBook
Chinese Japanese Germany Korea

Levofloxacin hydrochloride

Levofloxacin hydrochloride
Levofloxacin hydrochloride structure
CAS No.
100986-85-4
Chemical Name:
Levofloxacin hydrochloride
Synonyms
LVFX;dr3355;Cravit;HR 355;Crarit;Tavanic;Levaquin;RWJ 25213;Ophthalmic;Levofloxcin
CBNumber:
CB4122906
Molecular Formula:
C18H20FN3O4
Formula Weight:
361.37
MOL File:
100986-85-4.mol

Levofloxacin hydrochloride Properties

Melting point:
218°C
Boiling point:
572℃
Flash point:
>110°(230°F)
storage temp. 
Store at 0-5°C
solubility 
chloroform: soluble10mg/mL
form 
powder
color 
white to faint yellow
optical activity
[α]20/D -104±4° in chloroform
Water Solubility 
Slightly soluble in water or methanol. Soluble in glacial acetic acid or dichloromethane
Sensitive 
Light Sensitive
Merck 
14,6771
BRN 
7327015
InChIKey
GSDSWSVVBLHKDQ-JTQLQIEISA-N
CAS DataBase Reference
100986-85-4(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS02,GHS07,GHS08
Signal word  Danger
Hazard statements  H302-H317-H334-H361d-H362-H225-H302+H312+H332-H319
Precautionary statements  P280g-P284-P304+P340-P342+P311a-P501a-P261-P263-P280-P342+P311-P210-P305+P351+P338
Hazard Codes  Xn
Risk Statements  22-42/43-68-20/21/22-64-63
Safety Statements  26-36/37/39-36
RIDADR  UN 1648 3 / PGII
WGK Germany  3
RTECS  UU8815550
HS Code  29349990

Levofloxacin hydrochloride price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 28266 Levofloxacin ≥98.0% (HPLC) 100986-85-4 1g-f $39.4 2018-11-20 Buy
Sigma-Aldrich 28266 Levofloxacin ≥98.0% (HPLC) 100986-85-4 10mg-f $39.9 2018-11-20 Buy
TCI Chemical L0193 Levofloxacin >98.0%(HPLC) 100986-85-4 5g $39 2018-11-22 Buy
TCI Chemical L0193 Levofloxacin >98.0%(HPLC) 100986-85-4 25g $114 2018-11-22 Buy
Alfa Aesar J66943 Levofloxacin, 98% 100986-85-4 5g $38.7 2018-11-13 Buy

Levofloxacin hydrochloride Chemical Properties,Uses,Production

Description

Levofloxacin, the optically active S-isomer of the fluoroquinolone antibiotic ofloxacin, is two to four times more potent than ofloxacin with reportedly less side effects in treating infections of the lower respiratory and urinary tract, prostate infections and sexually transmitted diseases. It has broad and potent antibacterial activity over common Grampositive and -negative aerobic pathogens and obligate anaerobes. Different from the cephem antibiotics, levofloxacin is unique in its marked selectivity against members of the family Enterobacteriaceae and its negligible effect on predominant anaerobes. Levofloxacin also exhibits satisfactory antimicrobial effects in surgical infections and it may be used for treatment of gastrointestinal infections such as traveler’s diarrhea associated with the pathogenic Enterobacteriaceae.

Chemical Properties

Slight yellow powder

Originator

Daiichi (Japan)

Uses

Antibacterial.

brand name

Iquix (Sanofi Winthrop); Levaquin (Ortho-McNeil); Quixin (Sanofi Winthrop);Cravit.

Antimicrobial activity

Levofloxacin is the active component of ofloxacin; d-ofloxacin is without significant antibacterial activity. It exhibits good activity in vitro against Gram-positive cocci (including Str. pneumoniae), Enterobacteriaceae, some fastidious Gram-negative bacilli and Ps. aeruginosa as well as chlamydiae, Mycoplasma pneumoniae, L. pneumophila and M. tuberculosis. MICs for Acinetobacter spp. and Sten. maltophilia are 0.06–0.25 and 0.5–2.0 mg/L, respectively. Activity against anaerobes is moderate to low.

Pharmaceutical Applications

For molecular weight and structure, see ofloxacin . Levofloxacin is the l-isomer of ofloxacin.

Pharmacokinetics

Oral absorption: >95%
Cmax 500 mg oral: c. 5 mg/L after 1.5–2 h
750 mg oral: c. 8 mg/L after 1.5–2 h
500 mg intravenous (90-min infusion): c. 6 mg/L end infusion
750 mg intravenous (90-min infusion) :c. 12 mg/L end infusion
Plasma half-life :6–8 h
Volume of distribution:0.6–0.8 L/kg
Plasma protein binding: <25%
Co-administration with antacids, calcium, sucralfate and heavy metals decreases bioavailability and AUC. No interactions with warfarin or theophylline have been observed. Co-administration of a non-steroidal anti-inflammatory drug may increase the risk of convulsions. It undergoes limited metabolism and is primarily eliminated unchanged in urine by both glomerular filtration and tubular secretion. The free AUC:MIC ratio for Str. pneumoniae increases from about 55 to 70 when the daily dosage is raised from 500 mg to 750 mg.
It is stable in plasma and does not revert to d-ofloxacin. It undergoes limited metabolism and is primarily eliminated unchanged in the urine. Renal clearance in excess of the glomerular filtration rate suggests that tubular secretion also occurs. Concomitant administration of either cimetidine or probenecid reduces renal clearance by approximately onethird. Clearance is reduced and half-life is prolonged in patients with impaired renal function (creatinine clearance <50 mL/min) requiring dosage adjustment in such patients.

Clinical Use

Acute bacterial sinusitis
Acute bacterial exacerbations of chronic bronchitis, community-acquired pneumonia
Uncomplicated and complicated skin and skin structure infections
Uncomplicated and complicated urinary infections including acute pyelonephritis
Chronic bacterial prostatitis

Side effects

Side effects have been reported in 6–7% of patients and include fever, rash and other events common to the group. Elderly patients are at increased risk of developing severe tendon disorders including rupture, a risk increased by concomitant corticosteroid therapy.

Levofloxacin hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products


Levofloxacin hydrochloride Suppliers

Global( 286)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shaanxi Yikanglong Biotechnology Co., Ltd.
17791478691
yklbiotech@163.com CHINA 297 58
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3194 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
PI & PI BIOTECH INC.
020-81716320
020-81716319 Sales@pipitech.com CHINA 2543 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
02783214688 bruce@xrdchem.cn CHINA 535 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1861 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30001 58
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093 export@haihangchem.com CHINA 8921 58
QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409 orders@qcchemical.com United States 8407 58

View Lastest Price from Levofloxacin hydrochloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-10-09 Levofloxacin
100986-85-4
US $0.00 / Kg/Drum 25Kg/Drum 98.5~ 102.0% 1 tons HubeiwidelychemicaltechnologyCo.,Ltd
2019-10-10 Levofloxacin
100986-85-4
US $0.00 / Kg/Drum 25Kg/Drum 98.5~ 102.0% USP42 1 tons HubeiwidelychemicaltechnologyCo.,Ltd
2019-07-17 Levofloxacin hydrochloride
100986-85-4
US $1.00 / g 1g 99% 500 Ton/Tons per Month Cangzhou Wanyou New Material Technology Co.,Ltd

100986-85-4(Levofloxacin hydrochloride)Related Search:


Copyright 2017 © ChemicalBook. All rights reserved