Ethanone, 2-chloro-1-(3-indolyl)-
- CAS No.
- 28755-03-5
- Chemical Name:
- Ethanone, 2-chloro-1-(3-indolyl)-
- Synonyms
- 3CAI;3CAI >=95% (HPLC);3-chloroacetylindole;Akt Inhibitor XIX, 3CAI;Chloromethyl indol-3-yl ketone;3-(Chloroacetyl)-1H-indole 95%;2-Chloro-1-(3-Indolyl)-Ethanone;Ethanone, 2-chloro-1-(3-indolyl)-;Ethanone, 2-chloro-1H-indol-1-yl-;Ethanone, 2-chloro-1-(1H-indol-3-yl)-
- CBNumber:
- CB41247653
- Molecular Formula:
- C10H8ClNO
- Molecular Weight:
- 193.63
- MDL Number:
- MFCD00464796
- MOL File:
- 28755-03-5.mol
| Melting point | 212-214 °C(Solv: ethyl ether (60-29-7)) |
|---|---|
| Boiling point | 379.1±17.0 °C(Predicted) |
| Density | 1.337±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | DMSO: soluble5mg/mL, clear |
| form | powder |
| pka | 15.08±0.30(Predicted) |
| color | yellow to brown |
Ethanone, 2-chloro-1-(3-indolyl)- price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 124037 | Akt Inhibitor XIX, 3CAI | 28755-03-5 | 25mg | $195 | 2023-01-07 | Buy |
| Cayman Chemical | 14303 | 3CAI ≥95% | 28755-03-5 | 250mg | $93 | 2024-03-01 | Buy |
| Cayman Chemical | 14303 | 3CAI ≥95% | 28755-03-5 | 500mg | $166 | 2024-03-01 | Buy |
| Cayman Chemical | 14303 | 3CAI ≥95% | 28755-03-5 | 1g | $275 | 2024-03-01 | Buy |
| TRC | C382623 | 3-(Chloroacetyl)indole | 28755-03-5 | 1g | $290 | 2021-12-16 | Buy |
Ethanone, 2-chloro-1-(3-indolyl)- Chemical Properties,Uses,Production
Uses
3-(Chloroacetyl)indole is a reagent used in organic synthesis. Used in the preparation of 1,?2-?dihydroazepino[4,?5-?b]?indoles.
Biological Activity
3cai is a potent allosteric and specific inhibitor of akt, which directly binds with akt1 or akt2 in an atp noncompetitive manner and shows 60% inhibition of akt1 kinase activity at 1 μm [1]. the serine/threonine kinase akt includes three members, akt1, akt2, and akt3. akt plays a critical role in promoting transformation and chemoresistance through inducing proliferation and inhibiting apoptosis. therefore, akt is regarded as a potential target for cancer therapy.
in vitro
3cai (1 and 4 μm) significantly inhibited akt1 kinase activity and decreased expression of akt direct downstream targets including mtor and gsk3β, respectively. 3cai (4 μm) efficiently induced growth inhibition and apoptosis in hct116 or hct29 colon cancer cells [1].
in vivo
3cai (30 mg/kg, oral administration) significantly suppressed colon cancer growth in an in vivo xenograft mouse model and inhibited the expression of akt-target protein such as mtor and gsk3βin hct116 colon tumor tissues [1].
target
akt
IC 50
1 μm
References
1. kim dj, reddy k, kim mo, li y, nadas j, cho yy, et al. (3-chloroacetyl)-indole, a novel allosteric akt inhibitor, suppresses colon cancer growth in vitro and in vivo. cancer prev res (phila). 2011;4(11):1842-51.
Ethanone, 2-chloro-1-(3-indolyl)- Preparation Products And Raw materials
Ethanone, 2-chloro-1-(3-indolyl)- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Blocksynth Pharmaceutical Technology Co.,Ltd | 0086-19817745290; +8619817745290 | bd@blocksynth.com | China | 5657 | 58 |
| sgtlifesciences pvt ltd | +8617013299288 | dj@sgtlifesciences.com | China | 12382 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 6011 | 61 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |