ASOXIME CHLORIDE
- CAS No.
- 34433-31-3
- Chemical Name:
- ASOXIME CHLORIDE
- Synonyms
- hi6;hj6;hi-6;Transant;wr249655;Ccris 7699;HI 6 Chloride;hi-6dichloride;ASOXIME CHLORIDE;Asoxime dichloride
- CBNumber:
- CB4137803
- Molecular Formula:
- C14H16Cl2N4O3
- Molecular Weight:
- 359.21
- MDL Number:
- MFCD00869535
- MOL File:
- 34433-31-3.mol
- MSDS File:
- SDS
| Melting point | 145-147°C |
|---|---|
| storage temp. | -20°C |
| solubility | H2O: soluble15mg/mL (clear solution) |
| form | powder |
| color | white to beige |
| Stability | 1-10% Aqueous solution |
| FDA UNII | HUV88P6SJS |
ASOXIME CHLORIDE price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0224 | HI-6 ≥98% (HPLC) | 34433-31-3 | 10mg | $122 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0224 | HI-6 ≥98% (HPLC) | 34433-31-3 | 50mg | $491 | 2024-03-01 | Buy |
| Cayman Chemical | 18607 | Asoxime (chloride) ≥95% | 34433-31-3 | 5mg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 18607 | Asoxime (chloride) ≥95% | 34433-31-3 | 10mg | $92 | 2024-03-01 | Buy |
| Cayman Chemical | 18607 | Asoxime (chloride) ≥95% | 34433-31-3 | 25mg | $216 | 2024-03-01 | Buy |
ASOXIME CHLORIDE Chemical Properties,Uses,Production
Chemical Properties
Off-White Solid
Uses
Cholinesterase reactivator. A potential antidote for organophosphate poisoning
General Description
HI-6 functions as an antidote for treating intoxication caused by nerve agents. It acts as a potent drug in radiation protection and suppresses oxidative stress. HI-6 prevents the toxicity of the antineoplastic drug irinotecan.
Biological Activity
asoxime, also known as hi-6, is an asymmetric bis-pyridinium aldoxime and reactivates ache via nucleophilic attack of oximate anions on organophosphate-ache conjugates.ache, one of the primary targets of organophosphates, is inactivated by organophosphates via reacting covalently with the active center serine, which blocks the hydrolyzation of acetylcholine at peripheral and central synapses. additionally, the accumulation of acetylcholine leads to an over-stimulation of cholinergic receptors, which disrupts a variety of biological functions.
Biochem/physiol Actions
HI-6 is an efficient oxime cholinesterase reactivator that is used as an antidote for organophosphates (Ops) exposure.
in vitro
hi-6 showed a bacteriostatic effect on francisella tularensis (f. tularensis) and inhibited the growth of f. tularensis when treated with 100 mm hi-6 [1].
in vivo
female balb/c mice, infected by f. tularensis, were administrated subcutaneously with 100 μl hi-6 for ten days. the lower dose of hi-6 yielded in different symptoms and mortality. compared to mice injected only with tularemia, groups of mice exposed to the lower dose of hi-6 showed a decline in mortality, which can be explained via higher efficacy of bacteriostatic effect while the toxic effect was decreased [1]. female wistar rats were treated intramuscularly with hi-6 at a dose of 15.6 or 156 mg/kg for one day. the level of thiobarbituric acid reactive substances was increased, which was triggered by hi-62 [2].
IC 50
8.9 μm: blocks ache in human; 126 μm: inhibits acetylcholinesterase (ache) in bovine; 160 μm: blocks muscarinic acetylcholine receptor m1, m2, m3 and m4 in mouse.
References
[1]. pohanka, m., pavli, o., pikula, j., treml, f., & kuca, k. modulation of tularemia disease progress by the bisquaternary pyridinium oxime hi-6. acta veterinaria brno. 2010; 79(3): 443-448.
[2]. pohanka, m., sobotka, j., svobodova, h., & stetina, r. sulfur mustard induced oxidative stress and its alteration using asoxime (hi-6). interdisciplinary toxicology. 2013; 6(4).
ASOXIME CHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
ASOXIME CHLORIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Alfa Chemistry | 1-516-6625404 | support@alfa-chemistry.com | United States | 9171 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 56086 | 58 |
| Hefei Molake Biotechnology Co., Ltd. | 0551-66336380 18956014586 | 983438788@qq.com | China | 2116 | 58 |